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PID: 11546836, COI: 1:CAS:528:DC%2BD3MXntlels7g%3D, An extremely throrough and very well-documented review of the pathways and agents that regulate the erectile response
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Andersson KE: Pharmacology of penile erection. Pharmacol Rev 2001, 53:417–450. An extremely throrough and very well-documented review of the pathways and agents that regulate the erectile response.
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Kim NN, Goldstein I, Moreland RB, Traish AM: Alphaadrenergic receptor blockade by phentolamine increases the efficacy of vasodilators in penile corpus cavernosum. Int J Impot Res 2000, 12(Suppl 1):S26-S36. DOI: 10.1038/sj.ijir.3900504
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Kim, N.N.1
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Andersson KE, Hedlund P, Alm P: Sympathetic pathways and adrenergic innervation of the penis. Int J Impot Res 2000, 12(Suppl 1):S5–12. DOI: 10.1038/sj.ijir.3900513
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Traish A, Kim NN, Moreland RB, Goldstein I: Role of alpha adrenergic receptors in erectile function. Int J Impot Res 2000, 12(Suppl 1):S48-S63. DOI: 10.1038/sj.ijir.3900506
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Jong, M.Y.1
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Tasker, A.S.2
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15
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0032620047
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Pharmacomechanical coupling: the role of calcium, G-proteins, kinases and phosphatases
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PID: 10087910, COI: 1:CAS:528:DyaK1MXmsVeguw%3D%3D
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Somlyo AP, Wu X, Walker LA, Somlyo AV: Pharmacomechanical coupling: the role of calcium, G-proteins, kinases and phosphatases. Rev Physiol Biochem Pharmacol 1999, 134:201–234.
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0034650714
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Signal transduction by G-proteins rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II
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PID: 10639096, COI: 1:CAS:528:DC%2BD3cXht12ns7s%3D, An excellent overall review that demonstrates the importance of the RhoA/ Rho-kinase calcium sensitization pathway smooth muscle physiology
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Somlyo AP, Somlyo AV: Signal transduction by G-proteins rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II. J Physiol 2000, 522:177–185. An excellent overall review that demonstrates the importance of the RhoA/ Rho-kinase calcium sensitization pathway in smooth muscle physiology. DOI: 10.1111/j.1469-7793.2000.t01-2-00177.x
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0022272322
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Calcium-force relationships as detected with aequorin in two different vascular smooth muscles of the ferret
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PID: 4093883, COI: 1:STN:280:BimC2czksFU%3D
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0030640206
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Signal transduction in cavernous smooth muscle
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PID: 9066091, COI: 1:STN:280:ByiB3MfmsFA%3D
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Stief CG, Noack T, Andersson KE: Signal transduction in cavernous smooth muscle. World J Urol 1997, 15:27–31. DOI: 10.1007/BF01275153
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The role of nitric oxide in the physiology of erection
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PID: 7756443, COI: 1:CAS:528:DyaK2MXjslChs7Y%3D
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Localization of NADPH diaphorase and vasoactive intestinal polypeptide-containing neurons in the efferent pathway to the rat corpus cavernosum
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PID: 9266240, COI: 1:STN:280:ByiH3M7isVM%3D
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Tamura M, Kagawa S, Tsuruo Y, et al.: Localization of NADPH diaphorase and vasoactive intestinal polypeptide-containing neurons in the efferent pathway to the rat corpus cavernosum. Eur Urol 1997, 32:100–104.
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Tamura, M.1
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21
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0030333542
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A pilot study of the role of intracavernous injection of vasoactive intestinal peptide (VIP) and phentolamine mesylate in the treatment of erectile dysfunction
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PID: 8981173, COI: 1:STN:280:ByiC3srmtlI%3D
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McMahon CG: A pilot study of the role of intracavernous injection of vasoactive intestinal peptide (VIP) and phentolamine mesylate in the treatment of erectile dysfunction. Int J Impot Res 1996, 8:233–236.
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McMahon, C.G.1
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0030713093
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Comparison of responses to adrenomedullin and calcitonin generelated peptide in the feline erection model
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PID: 9349749
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Champion HC, Wang R, Santiago JA, et al.: Comparison of responses to adrenomedullin and calcitonin generelated peptide in the feline erection model. J Androl 1997, 18:513–521.
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0028200170
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Intracavernous calcitonin gene-related peptide plus prostaglandin E1: possible alternative to penile implants in selected patients
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PID: 7925528, COI: 1:STN:280:ByqD3M%2FitVw%3D
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0027266895
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Followup results of a combination of calcitonin gene-related peptide and prostaglandin E1 in the treatment of erectile dysfunction
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PID: 8479019, COI: 1:STN:280:ByyB2c%2FmtlQ%3D
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Djamilian M, Stief CG, Kuczyk M, Jonas U: Followup results of a combination of calcitonin gene-related peptide and prostaglandin E1 in the treatment of erectile dysfunction. J Urol 1993, 149:1296–1298.
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0034647534
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Cyclic GMP-dependent protein kinase signaling pathway inhibits RhoA-induced Ca2+ sensitization of contraction in vascular smooth muscle
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PID: 10783386, COI: 1:CAS:528:DC%2BD3cXkvFGit74%3D
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Sauzeau V, Le Jeune H, Cario-Toumaniantz C, et al.: Cyclic GMP-dependent protein kinase signaling pathway inhibits RhoA-induced Ca2+ sensitization of contraction in vascular smooth muscle. J Biol Chem 2000, 275:21722–21729. DOI: 10.1074/jbc.M000753200
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0029313137
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Effect of vasoactive intestinal peptide and acetylcholine on penile erection in the rat in vivo
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PID: 7496439, COI: 1:STN:280:BymD1M7ot1A%3D
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0032845246
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Potentiation of erectile response and cAMP accumulation by combination of prostaglandin E1 and rolipram, a selective inhibitor of the type 4 phosphodiesterase (PDE 4)
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PID: 10524946, COI: 1:CAS:528:DyaK1MXntVWhsb4%3D
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Bivalacqua TJ, Champion HC, Rajasekaran MA, et al.: Potentiation of erectile response and cAMP accumulation by combination of prostaglandin E1 and rolipram, a selective inhibitor of the type 4 phosphodiesterase (PDE 4). J Urol 1999, 162:1848–1855. DOI: 10.1016/S0022-5347(05)68249-3
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9444295328
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Nitric oxidedependent penile erection in mice lacking neuronal nitric oxide synthase
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PID: 8784782, COI: 1:CAS:528:DyaK28Xkt1Omsrk%3D
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0032516296
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Oral sildenafil in the treatment of erectile dysfunction. Sildenafil Study Group
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PID: 9580646, COI: 1:CAS:528:DyaK1cXjsVWitbs%3D
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Goldstein I, Lue TF, Padma-Nathan H, et al.: Oral sildenafil in the treatment of erectile dysfunction. Sildenafil Study Group. New Engl J Med 1998, 338:1397–1404. DOI: 10.1056/NEJM199805143382001
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Goldstein, I.1
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0034863248
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Effect of Rho-kinase inhibition on vasoconstriction in the penile circulation
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PID: 11509525, COI: 1:CAS:528:DC%2BD3MXmvV2qtrY%3D
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Mills TM, Chitaley K, Wingard CJ, et al.: Effect of Rho-kinase inhibition on vasoconstriction in the penile circulation. J Appl Physiol 2001, 91:1269–1273.
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Mills, T.M.1
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0034992988
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RhoA/Rho-kinase: a novel player in the regulation of penile erection
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PID: 11426341, COI: 1:STN:280:DC%2BD3MzmtlGisg%3D%3D
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Chitaley K, Webb RC, Mills TM: RhoA/Rho-kinase: a novel player in the regulation of penile erection. Int J Impot Res 2001, 13:67–72. DOI: 10.1038/sj.ijir.3900647
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Int J Impot Res
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Antagonism of Rho-kinase stimulates rat penile erection via a nitric oxide-independent pathway
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PID: 11135626, COI: 1:CAS:528:DC%2BD3MXmvFWrsw%3D%3D, The first demonstration of the importance of the RhoA/Rho-kinase pathway the erectile response of the mammalian penis. These studies showed that both RhoA and Rho-kinase proteins are present rat erectile tissue. Furthermore, through the use of inhibitors and guanylate cyclase, the experiments showed that inhibition of Rho-kinase leading to erection did not activate NO/cGMPdependent vasorelaxation
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Chitaley K, Wingard C, Clinton Webb R, et al.: Antagonism of Rho-kinase stimulates rat penile erection via a nitric oxide-independent pathway. Nat Med 2001, 7:119–122. The first demonstration of the importance of the RhoA/Rho-kinase pathway in the erectile response of the mammalian penis. These studies showed that both RhoA and Rho-kinase proteins are present in rat erectile tissue. Furthermore, through the use of NOS inhibitors and guanylate cyclase, the experiments showed that inhibition of Rho-kinase leading to erection did not activate NO/cGMPdependent vasorelaxation. DOI: 10.1038/83258
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Nat Med
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Chitaley, K.1
Wingard, C.2
Clinton, W.R.3
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34
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0036186520
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Human and rabbit cavernosal smooth muscle cells express Rho-kinase
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PID: 11896471, COI: 1:STN:280:DC%2BD387msVahsQ%3D%3D
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Rees RW, Ziessen T, Ralph DJ, et al.: Human and rabbit cavernosal smooth muscle cells express Rho-kinase. Int J Impot Res 2002, 14:1–7. DOI: 10.1038/sj.ijir.3900814
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Rees, R.W.1
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35
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0034955766
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Y-27632, an inhibitor of Rho-kinase antagonizes noradrenergic contractions in the rabbit and human penile corpus cavernosum
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PID: 11399661, COI: 1:CAS:528:DC%2BD3MXkvFSltLY%3D
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Rees RW, Ralph DJ, Royle M, et al.: Y-27632, an inhibitor of Rho-kinase antagonizes noradrenergic contractions in the rabbit and human penile corpus cavernosum. Br J Pharmacol 2001, 133:455–458. DOI: 10.1038/sj.bjp.0704124
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Br J Pharmacol
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Rees, R.W.1
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0034884487
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Erection and NO override the vasoconstrictor effect of alpha adrenergic stimulation in the rat penile vasculature
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PID: 11494078, COI: 1:STN:280:DC%2BD3Mvks1eguw%3D%3D
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Wingard C, Lewis R, Mills T: Erection and NO override the vasoconstrictor effect of alpha adrenergic stimulation in the rat penile vasculature. Int J Impot Res 2001, 13(Suppl 5):212–220. DOI: 10.1038/sj.ijir.3900688
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Int J Impot Res
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0031055155
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Androgens modulate the alpha-adrenergic responsiveness of vascular smooth muscle in the corpus cavernosum
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PID: 9089065, COI: 1:CAS:528:DyaK2sXit12murs%3D
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Reilly CM, Stopper VS, Mills TM: Androgens modulate the alpha-adrenergic responsiveness of vascular smooth muscle in the corpus cavernosum. J Androl 1997, 18:26–31.
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J Androl
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Reilly, C.M.1
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0036181829
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Nitric oxide induces dilation of rat aorta via inhibition of Rho-kinase signaling
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PID: 11882586, COI: 1:CAS:528:DC%2BD38Xhs1Wlt74%3D
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Chitaley K, Webb RC: Nitric oxide induces dilation of rat aorta via inhibition of Rho-kinase signaling. Hypertension 2002, 39:438–442. DOI: 10.1161/hy02t2.102960
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Hypertension
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Chitaley, K.1
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0037192607
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Nitric oxide inhibits RhoA/Rho-kinase signaling to cause erection
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PID: 11937108, COI: 1:CAS:528:DC%2BD38XisV2rs7o%3D, These studies support the hypothesis that an important action of NO leading to erection is the inhibition of the RhoA/Rho-kinase pathway
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Mills TM, Chitaley K, Lewis RW, Webb RC: Nitric oxide inhibits RhoA/Rho-kinase signaling to cause erection. Eur J Pharmacol 2002, 439:173–174. These studies support the hypothesis that an important action of NO leading to erection is the inhibition of the RhoA/Rho-kinase pathway. DOI: 10.1016/S0014-2999(02)01408-5
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Eur J Pharmacol
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In press
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Chitaley K, Webb RC, Mills TM: The ups and downs of Rho-kinase and penile erection: upstream regulators and downstream substrates of Rho-kinase and their potential role in the erectile response. Int J Impot Res 2002, In press.
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Decreased penile erection in DOCA-salt and stroke prone-spontaneously hypertensive rats
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