Brimonidine evokes heterogeneous vasomotor response of retinal arterioles: Diminished nitric oxide-mediated vasodilation when size goes small

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 291, Issue 1, 2006, Pages

  Rosa Jr , Robert H ^a   Hein, Travis W ^a   Yuan, Zhaoxu ^a   Xu, Wenjuan ^a   Pechal, Melissa I ^a   Geraets, Ryan L ^a   Newman, Joseph M ^a   Kuo, Lih ^a,b  

^a SCOTT AND WHITE MEMORIAL HOSPITAL   (United States)

^b TEXAS A AND M UNIVERSITY SYSTEM   (United States)

Author keywords

Retinal blood flow; Retinal microcirculation

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BRIMONIDINE; ESTER DERIVATIVE; MESSENGER RNA; N G NITRO LEVO ARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; RAUWOLSCINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERIAL PRESSURE; ARTERY CONSTRICTION; ARTERY DIAMETER; ARTERY LIGATION; ARTICLE; CANNULATION; CELL HETEROGENEITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG EFFECT; ENDOTHELIUM CELL; FEMALE; GENE EXPRESSION; IN VITRO STUDY; INCIDENCE; MALE; MICROSCOPY; NONHUMAN; PRIORITY JOURNAL; RETINA ARTERY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SWINE; VASODILATATION; VASOMOTOR REFLEX;

ADRENERGIC ALPHA-AGONISTS; ANIMALS; ARTERIOLES; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; MALE; NITRIC OXIDE; QUINOXALINES; RECEPTORS, ADRENERGIC, ALPHA-2; RETINAL ARTERY; SWINE; VASODILATION; VASOMOTOR SYSTEM;

EID: 33745712680     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.01281.2005     Document Type: Article

References (51)

1. Acheampong AA, Shackleton M, John B, Burke J, Wheeler L, and Tang-Liu D. Distribution of brimonidine into anterior and posterior tissues of monkey, rabbit, and rat eyes. Drug Metab Dispos 30: 421-429, 2002.
2. Aleixandre A, Lopez-Miranda V, and Ortega A. Alpha-vascular responses after short-term and long-term inhibition of nitric oxide synthesis. J Cardiovasc Pharmacol 37: 133-142, 2001.
3. Anderson KM and Faber JE. Differential sensitivity of arteriolar alpha 1- and alpha 2-adrenoceptor constriction to metabolic inhibition during rat skeletal muscle contraction. Circ Res 69: 174-184, 1991.
4. Bakker EN, van der Linden PJ, and Sipkema P. Endothelin-1-induced constriction inhibits nitric-oxide-mediated dilation in isolated rat resistance arteries. J Vasc Res 34: 418-424, 1997.
5. Bockman CS, Gonzalez-Cabrera I, and Abel PW. Alpha-2 adrenoceptor subtype causing nitric oxide-mediated vascular relaxation in rats. J Pharmacol Exp Ther 278: 1235-1243, 1996.
6. Bockman CS, Jeffries WB, and Abel PW. Binding and functional characterization of alpha-2 adrenergic receptor subtypes on pig vascular endothelium. J Pharmacol Exp Ther 267: 1126-1133, 1993.
7. Bryan RM Jr. Stimulation of alpha 2 adrenoceptors dilates the rat middle cerebral artery. Anesthesiology 85: 82-90, 1996.
8. Burke J and Schwartz M. Preclinical evaluation of brimonidine. Surv Ophthalmol 41, Suppl 1: S9-S18, 1996.
9. Bylund DB and Chacko DM. Characterization of alpha2 adrenergic receptor subtypes in human ocular tissue homogenates. Invest Ophthalmol Vis Sci 40: 2299-2306, 1999.
10. Cameron EM, Wang SY, Fink MP, and Sellke FW. Mesenteric and skeletal muscle microvascular responsiveness in subacute sepsis. Shock 9: 184-192, 1998.
11. Carlsson AM, Chauhan BC, Lee AA, and LeBlanc RP. The effect of brimonidine tartrate on retinal blood flow in patients with ocular hypertension. Am J Ophthalmol 129: 297-301, 2000.
12. 2- receptors in escape from sympathetic vasoconstriction. Am J Physiol Heart Circ Physiol 261: H868-H873, 1991.
13. 1-adrenergic constriction of coronary arterioles. Am J Physiol Heart Circ Physiol 268: H2487-H2494, 1995.
14. Donello JE, Padillo EU, Webster ML, Wheeler LA, and Gil DW. Alpha(2)-adrenoceptor agonists inhibit vitreal glutamate and aspartate accumulation and preserve retinal function after transient ischemia. J Pharmacol Exp Ther 296: 216-223, 2001.
15. Dorner G, Garhofer G, Kiss B, Polska E, Polak K, Riva C, and Schmetterer L. Nitric oxide regulates retinal vascular tone in humans. Am J Physiol Heart Circ Physiol 285: H631-H636, 2003.
16. Dumskyj MJ, Eriksen JE, Dore CJ, and Kohner EM. Autoregulation in the human retinal circulation: assessment using isometric exercise, laser Doppler velocimetry, and computer-assisted image analysis. Microvasc Res 51: 378-392, 1996.
17. Emre M, Orgül S, Haufschild T, Shaw S, and Flammer J. Increased plasma endothelin-1 levels in patients with progressive open angle glaucoma. Br J Ophthalmol 89: 60-63, 2005.
18. Gao H, Qiao X, Cantor LB, and WuDunn D. Up-regulation of brain-derived neurotrophic factor expression by brimonidine in rat retinal ganglion cells. Arch Ophthalmol 120: 797-803, 2002.
19. Gilbert P, Tremblay J, and Thorin E. Endothelium-derived endothelin-1 reduces cerebral artery sensitivity to nitric oxide by a protein kinase C-independent pathway. Stroke 32: 2351-2355, 2001.
20. Glucksberg MR and Dunn R. Direct measurement of retinal microvascular pressures in the live, anesthetized cat. Microvasc Res 45: 158-165, 1993.
21. Greenfield DS, Liebmann JM, and Ritch R. Brimonidine: a new alpha2-adrenoreceptor agonist for glaucoma treatment. J Glaucoma 6: 250-258, 1997.
22. ATP channels in retinal arteriolar dilation in response to adenosine. Invest Ophthalmol Vis Sci 46: 2113-2119, 2005.
23. Hughes AD, Thom SA, Martin GN, Nielsen H, Hair WM, Schachter M, and Sever PS. Size and site-dependent heterogeneity of human vascular responses in vitro. J Hypertens Suppl 6: S173-S175, 1988.
24. Jonescu-Cuypers CP, Harris A, Ishii Y, Kagemann L, Gazozi HJ, Rotenstreich Y, Chung HS, and Martin B. Effect of brimonidine tartrate on ocular hemodynamics in healthy volunteers. J Ocul Pharmacol Ther 17: 199-205, 2001.
25. Kanzow UPL, Bohm AG, Katz AB, and Richard G. Scanning laser Doppler flowmetry after topical brimonidine administration (Abstract). Invest Ophthalmol Vis Sci 39: S271, 1998.
26. Kent AR, Nussdorf JD, David R, Tyson F, Small D, and Fellows D. Vitreous concentration of topically applied brimonidine tartrate 0.2%. Ophthalmology 108: 784-787, 2001.
27. Kulkarni P, Joshua IG, Roberts AM, and Barnes G. A novel method to assess reactivities of retinal microcirculation. Microvasc Res 48: 39-49, 1994.
28. Kuo L, Chilian W, and Davis M. Interaction of pressure- and flow-induced responses in porcine coronary resistance vessels. Am J Physiol Heart Circ Physiol 261: H1706-H1715, 1991.
29. Lachkar Y, Migdal C, and Dhanjil S. Effect of brimonidine tartrate on ocular hemodynamic measurements. Arch Ophthalmol 116: 1591-1594, 1998.
30. Lai RK, Chun T, Hasson D, Lee S, Mehrbod F, and Wheeler L. Alpha-2 adrenoceptor agonist protects retinal function after acute retinal ischemic injury in the rat. Vis Neurosci 19: 175-185, 2002.
31. Liu CJ, Ko YC, Cheng CY, Chou JC, Hsu WM, and Liu JH. Effect of latanoprost 0.005% and brimonidine tartrate 0.2% on pulsatile ocular blood flow in normal tension glaucoma. Br J Ophthalmol 86: 1236-1239, 2002.
32. Mather KJ, Lteif A, Steinberg HO, and Baron AD. Interactions between endothelin and nitric oxide in the regulation of vascular tone in obesity and diabetes. Diabetes 53: 2060-2066, 2004.
33. Matsuo T and Cynader M. Localization of alpha-2 adrenergic receptors in the human eye. Ophthalmic Res 24: 213-219, 1992.
34. McGillivray-Anderson KM and Faber JE. Effect of reduced blood flow on alpha 1- and alpha 2-adrenoceptor constriction of rat skeletal muscle microvessels. Circ Res 69: 165-173, 1991.
35. Ohyanagi M, Faber JE, and Nishigaki K. Differential activation of alpha 1- and alpha 2-adrenoceptors on microvascular smooth muscle during sympathetic nerve stimulation. Circ Res 68: 232-244, 1991.
36. Poinoosawmy D, Indar A, Bunce C, Garway-Heath DF, and Hitchings RA. Effect of treatment by medicine or surgery on intraocular pressure and pulsatile ocular blood flow in normal-pressure glaucoma. Graefes Arch Clin Exp Ophthalmol 240: 721-726, 2002.
37. Prasanna G, Hulet C, Desai D, Krishnamoorthy RR, Narayan S, Brun AM, Suburo AM, and Yorio T. Effect of elevated intraocular pressure on endothelin-1 in a rat model of glaucoma. Pharmacol Res 51: 41-50, 2005.
38. Rolle T, Cipullo D, Vizzeri GM, Triggiani A, and Brogliatti B. Evaluation and comparison between the effects on intraocular pressure and retinal blood flow of two antiglaucomatous drugs administered in monotherapy: brimonidine and latanoprost. Preliminary results. Acta Ophthalmol Scand Suppl: 50-52, 2000.
39. 2-adrenergic vasoconstriction is blunted in contracting human muscle. J Physiol 547: 971-976, 2003.
40. Sampaolesi J, Tosi J, Darchuk V, Ucha RA, Marengo J, and Sampaolesi R. Antiglaucomatous drugs effects on optic nerve head flow: design, baseline and preliminary report. Int Ophthalmol 23: 359-367, 2001.
41. Schmidt KG, Klingmuller V, Gouveia SM, Osborne NN, and Pillunat LE. Short posterior ciliary artery, central retinal artery, and choroidal hemodynamics in brimonidine-treated primary open-angle glaucoma patients. Am J Ophthalmol 136: 1038-1048, 2003.
42. Spada CS, Nieves AL, Burke JA, Wheeler LA, and Woodward DF. Differential effects of alpha-adrenoceptor agonists on human retinal microvessel diameter. J Ocul Pharmacol Ther 17: 255-277, 2001.
43. Sunano S, Li-Bo Z, Matsuda K, Sekiguchi F, Watanabe H, and Shimamura K. Endothelium-dependent relaxation by alpha 2-adrenoceptor agonists in spontaneously hypertensive rat aorta. J Cardiovasc Pharmacol 27: 733-739, 1996.
44. 1-adrenoceptor constriction by acidosis and hypoxia in vitro. Am J Physiol Heart Circ Physiol 268: H2068-H2076, 1995.
45. Tezel G, Kass MA, Kolker AE, Becker B, and Wax MB. Plasma and aqueous humor endothelin levels in primary open-angle glaucoma. J Glaucoma 6: 83-89, 1997.
46. Thorin E, Huang PL, Fishman MC, and Bevan JA. Nitric oxide inhibits alpha2-adrenoceptor-mediated endothelium-dependent vasodilation. Circ Res 82: 1323-1329, 1998.
47. Thorin E, Nguyen TD, and Bouthillier A. Control of vascular tone by endogenous endothelin-1 in human pial arteries. Stroke 29: 175-180, 1998.
48. Vanhoutte PM. Endothelial adrenoceptors. J Cardiovasc Pharmacol 38: 796-808, 2001.
49. Vetrugno M, Maino A, Cantatore F, Ruggeri G, and Cardia L. Acute and chronic effects of brimonidine 0.2% on intraocular pressure and pulsatile ocular blood flow in patients with primary open-angle glaucoma: an open-label, uncontrolled, prospective study. Clin Ther 23: 1519-1528, 2001.
50. Wikberg-Matsson A, Wikberg JE, and Uhlen S. Characterization of alpha 2-adrenoceptor subtypes in the porcine eye: identification of alpha 2A-adrenoceptors in the choroid, ciliary body and iris, and alpha 2A- and alpha 2C-adrenoceptors in the retina. Exp Eye Res 63: 57-66, 1996.
51. Zhang C, Hein TW, Wang W, Chang CI, and Kuo L. Constitutive expression of arginase in microvascular endothelial cells counteracts nitric oxide-mediated vasodilatory function. FASEB J 15: 1264-1266, 2001.