Endothelium-dependent relaxation by α2-adrenoceptor agonists in spontaneously hypertensive rat aorta

Journal of Cardiovascular Pharmacology

Volumn 27, Issue 5, 1996, Pages 733-739

  Sunano, Satoru ^a   Li Bo, Zou ^a   Matsuda, Kyoko ^a   Sekiguchi, Fumiko ^a   Watanabe, Hiromi ^a   Shimamura, Keiichi ^a  

^a KINKI UNIVERSITY   (Japan)

Author keywords

2 Adrenoceptor; Endothelium derived relaxing factor; Spontaneously hypertensive rats

Indexed keywords

9,11 EPITHIO 11,12 METHANOTHROMBOXANE A2; ACETYLCHOLINE; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BRIMONIDINE; CLONIDINE; ENDOTHELIUM DERIVED CONSTRICTING FACTOR; INDOMETACIN; N(G) NITROARGININE; NITRIC OXIDE; THROMBOXANE A2 DERIVATIVE; YOHIMBINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG SCREENING; HYPERTENSION; NONHUMAN; PRIORITY JOURNAL; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; VASODILATATION;

ACETYLCHOLINE; ADRENERGIC ALPHA-AGONISTS; ANIMALS; AORTA; ENDOTHELIUM, VASCULAR; HYPERTENSION; INDOMETHACIN; NITROARGININE; QUINOXALINES; RATS; RATS, INBRED SHR; RATS, INBRED WKY; RECEPTORS, ADRENERGIC, ALPHA-2; THROMBOXANE A2; VASODILATION;

EID: 0029935131     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-199605000-00017     Document Type: Article

References (43)

1. Konishi M, Su C. Role of endothelium in dilator responses of spontaneously hypertensive rat arteries. Hypertension 1989;5: 881-6.
2. Luscher TF, Vanhoutte PM. Endothelium-dependent contractions to acetylcholine in the aorta of the spontaneously hypertensive rat. Hypertension 1986;8:344-8.
3. Sunano S, Osugi S, Shimamura K. Blood pressure and impairment of endothelium-dependent relaxation in spontaneously hypertensive rats. Experientia 1989;45:705-8.
4. Sunano S, Osugi S, Kaneko K, Yamamoto K, Shimamura K. Effects of chronic treatment with SQ29852 on spontaneous smooth muscle tone and endothelium-dependent relaxation in aorta of stroke-prone spontaneously hypertensive rats. J Cardiovasc Pharmacol 1992;19:602-9.
5. Luscher TF, Vanhoutte PM. Endothelium-dependent contractions to acetylcholine in the aorta of the spontaneously hypertensive rats. Hypertension 1986;8:344-8.
6. Luscher TF, Raij L, Vanhoutte PM. Endothelium-dependent vascular responses in normotensive and hypertensive Dahl rats. Hypertension 1987;9:157-63.
7. Taddei S, Virdis A, Mattei P, Salvetti A. Vasodilation to acetylcholine in primary and secondary forms of human hypertension. Hypertension 1993;21:929-33.
8. 2 may be the endothelium-derived contracting factor released by acetylcholine in the aorta of the rat. Hypertension 1990;15:475-81.
9. Diedrich D, Yang Z, Buhler FR, Luscher T. Impaired endothelium-dependent relaxations in hypertensive resistance arteries involve cyclooxygenase pathway. Am J Physiol 1990;258:H445-51.
10. 2 are contractile factors in intrarenal arteries of spontaneously hypertensive rats. Hypertension 1992;19:795-8.
11. Li J, Bukoski RD. Endothelium-dependent relaxation of hypertensive resistance arteries is not impaired under all conditions. Circ Res 1993;72:290-6.
12. Mombouli J-V, Vanhoutte PM. Purinergic endothelium-dependent and -independent contractions in rat aorta. Hypertension 1993;22: 577-83.
13. 2-adrenoceptors in canine pulmonary and systemic blood vessels. Eur J Pharmacol 1985; 118:123-9.
14. 2-adrenoceptor agonist-induced contraction in rat mesenteric artery upon removal of endothelium. Eur J Pharmacol 1986;122:349-52.
15. Bullock GR, Taylor SG, Westone AH. Influence of the vascular endothelium on agonist-induced contractions and relaxations in rat aorta. Br J Pharmacol 1986;89:819-30.
16. Godfraind T, Alosachie I. Influence of endothelium and cyclic GMP on alpha-adrenoceptors. In: Vanhoutte PM, ed. Vasodilatation: vascular smooth muscle, peptide, autonomic nerves, and endothelium. New York: Raven Press, 1988:437-42.
17. Osugi S, Shimamura K, Sunano S. Decreased modulation by endothelium of noradrenaline-induced contraction in aorta from stroke-prone spontaneously hypertensive rats. Arch Int Pharmacodyn 1990;305:86-99.
18. Kaneko K, Sunano S (1993) Involvement of α-adrenoceptors in the endothelium-dependent depression of noradrenaline-induced contraction in rat aorta. Eur J Pharmacol 1993;240:195-200.
19. Egleme C, Godfraind T, Miller RC. Enhanced responsiveness of rat isolated aorta to clonidine after removal of the endothelium cells. Br J Pharmacol 1984;81:16-8.
20. Medgett IC, Hicks PE, Langer SZ. Smooth muscle alpha-2 adrenoceptors mediate vasoconstrictor responses to exogenous norepinephrine and to sympathetic stimulation to a greater extent in spontaneously hypertensive than in Wistar Kyoto rat tail arteries. J Pharmacol Exp Ther 1984;231:159-65.
21. Okamoto K, Yamori Y, Nagaoka A. Establishment of stroke-prone spontaneously hypertensive rats (SHR). Circ Res 1974;34/ 35(suppl):143-53.
22. Sunano S, Sasaki F, Osugi S, Shimamura K. Comparison of endothelium-dependent and -independent tension oscillation in aortae of stroke-prone spontaneously hypertensive rats and Wistar Kyoto rats. J Smooth Muscle Res 1994;30:135-45.
23. 2-agonist for the characterization of α-adrenoceptor subtypes. Eur J Pharmacol 1981;72:413-5.
24. 2 analogs and prostaglandins in isolated dog arteries. J Cardiovasc Pharmacol 1986;8:818-25.
25. Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980;288:373-6.
26. 2-adrenoceptor-mediated dilations in rat cerebral arteries. Am J Physiol 1995;269: H1171-4.
27. Martin W, Furchgott RF, Villani GM, Jothianandan D. Depression of contractile responses in rat aorta by spontaneously released endothelium-derived relaxing factor. J Pharmacol Exp Ther 1986; 237:529-38.
28. Cooks TM, Angus JA. Endothelium-dependent relaxation of coronary arteries by noradrenaline and serotonin. Nature 1983;305: 627-30.
29. Murakami K, Karaki H, Urakawa N. Role of endothelium in the contraction induced by norepinephrine and clonidine in rat aorta. Jpn J Pharmacol 1985;39:357-64.
30. Urabe M, Kawasaki H, Takasaki K. Effect of endothelium removal on the vasoconstrictor response to neurally released 5-hydroxytryptamine and noradrenaline in the rat isolated mesenteric and femoral arteries. Br J Pharmacol 1991;102:85-90.
31. Vo PA, Reid JJ, Rand MJ. Attenuation of vasoconstriction by endogenous nitric oxide in rat caudal artery. Br J Pharmacol 1992; 107:1121-8.
32. Kaneko K, Yamamoto K, Sasaki F, Sunano S. Effects of nitric oxide (NO) synthesis inhibitor in aorta of SHRSP. Jpn Heart J 1993;34:503.
33. G-nitro arginine (L-NOARG), a novel, L-arginine-reversible inhibitor of endothelium-dependent vasodilation in vitro. Br J Pharmacol 1990;99:408-12.
34. Grant JA, Scrutton MC. Interaction of selective α-adrenoceptor agonists and antagonists with human and rabbit blood platelets. Br J Pharmacol 1980;71:121-34.
35. Moncada S, Palmer RMJ, Higgs EA. Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol Rev 1991;43:109-42.
36. Carrier GO, White RE. Enhancement of alpha-1 and alpha-2 agonist-induced vasoconstriction by removal of endothelium in rat aorta. J Pharmacol Exp Ther 1985;232:682-7.
37. Luscher TF, Vanhoutte PM. Mechanisms of altered endothelium-dependent responses in hypertensive blood vessels. In: Vanhoutte PM, ed. Relaxing and contracting factors. Clifton. NJ: Humana Press, 1988:495-509.
38. Butler AR, Flitney FW, Williams DLH. NO, nitrosonium ions, nitroxide ions, nitrosothiols and iron-nitrosyls in biology: a chemist's perspective. Trends Pharmacol Sci 1995;16:18-22.
39. Bhalla RC, Aqel MB, Sharma RV. Alpha 1-adrenoceptor-mediated responses in the vascular smooth muscle of spontaneously hypertensive rats. J Hypertens 1986;4(suppl):s65-7.
40. 2 adrenoceptors on arterial smooth muscle and brain homogenates from spontaneously hypertensive and Wistar-Kyoto rats. J Hypertens 1984; 2:249-55.
41. Pearson PJ, Vanhoutte PM. Vasodilator and vasoconstrictor substances produced by the endothelium. Rev Physiol Biochem Pharmacol 1993;122:1-67.
42. iα2. J Biol Chem 1993;268:19528-33.
43. 3-muscarinic receptors of both endothelium-dependent contraction and relaxation to acetylcholine in the aorta of the spontaneously hypertensive rat. Br J Pharmacol 1994;112:519-24.