Chemistry of ecteinascidins. Part 2. Preparation of 6′-O-acyl derivatives of stable ecteinascidin and evaluation of cytotoxicity

Chemical and Pharmaceutical Bulletin

Volumn 54, Issue 7, 2006, Pages 1010-1016

  Puthongking, Ploenthip ^a   Patarapanich, Chamnan ^a   Amnuoypol, Surattana ^a   Suwanborirux, Khanit ^a   Kubo, Akinori ^b   Saito, Naoki ^b  

^a CHULALONGKORN UNIVERSITY   (Thailand)

^b MEIJI PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Acyl derivative; Cytotoxicity; Ecteinascidia thurstoni; Ecteinascidin 770

Indexed keywords

ACETIC ACID DERIVATIVE; ANTINEOPLASTIC ALKALOID; BENZOIC ACID DERIVATIVE; BUFFER; CARBOXYLIC ACID DERIVATIVE; DIACETYLECTEINASCIDIN 743; DIACETYLECTEINASCIDIN 770; DIACETYLECTEINASCIDIN 786; ECTEINASCIDIN 770; ECTEINASCIDIN 770 6' O 1'' ISOQUINOLINECARBOXYLIC ACID; ECTEINASCIDIN 770 6' O 1'' NAPHTHOATE; ECTEINASCIDIN 770 6' O 2'' BROMOBENZOIC ACID; ECTEINASCIDIN 770 6' O 2'' METHOXYBENZOIC ACID; ECTEINASCIDIN 770 6' O 2'' NAPHTHOATE; ECTEINASCIDIN 770 6' O 2'' QUINOLINECARBOXYLIC ACID; ECTEINASCIDIN 770 6' O 3'' ISOQUINOLINECARBOXYLIC ACID; ECTEINASCIDIN 770 6' O 4'' METHOXYBENZOIC ACID; ECTEINASCIDIN 770 6' O 4'' QUINOLINECARBOXYLIC ACID; ECTEINASCIDIN 770 6' O ISONICOTINIC ACID; ECTEINASCIDIN 770 6' O NICOTINIC ACID; ECTEINASCIDIN 770 6'O 2'' NITROBENZOIC ACID; ECTEINASCIDIN 770 6'O 3'' BROMOBENZOIC ACID; ECTEINASCIDIN 770 6'O 3'' NITROBENZOIC ACID; ECTEINASCIDIN 770 6'O 4'' BROMOBENZOIC ACID; ECTEINASCIDIN 770 6'O 4'' NITROBENZOIC ACID; ECTEINASCIDIN 770 6'O BENZOIC ACID; ECTEINASCIDIN 786; ESTER DERIVATIVE; NICOTINIC ACID DERIVATIVE; POTASSIUM CYANIDE; UNCLASSIFIED DRUG;

ARTICLE; CORAL; CYTOTOXICITY; DRUG ACTIVITY; DRUG ISOLATION; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; PH;

ACYLATION; ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; DRUG STABILITY; ESTERS; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; UROCHORDATA;

EID: 33745699988     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.54.1010     Document Type: Article

References (18)

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18. Dedicated to the late Professor Kenneth L. Rinehart (University of Illinois, Urbana) for his pioneering work in the field of ecteinascidin natural marine products.