Ethanol-ecstasy (MDMA) interactions in rats: Preserved attenuation of hyperthermia and potentiation of hyperactivity by ethanol despite prior ethanol treatment

Pharmacology Biochemistry and Behavior

Volumn 84, Issue 1, 2006, Pages 162-168

  Hamida, Sami Ben ^a   Bach, Sonia ^a   Plute, Erin ^a   Jones, Byron C ^b   Kelche, Christian ^a   Cassel, Jean Christophe ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

^b PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

( ) 3,4 Methylenedioxymethamphetamine; Ecstasy; Ethanol; Locomotor activity; Rats; Temperature; Tolerance

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; ALCOHOL;

ALCOHOL CONSUMPTION; ALCOHOL TOLERANCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY TEMPERATURE; CONTROLLED STUDY; FEVER; HYPERACTIVITY; HYPERTHERMIA; LOCOMOTION; MALE; NONHUMAN; PRIORITY JOURNAL; PSYCHOMOTOR PERFORMANCE; RAT;

ANIMALS; BODY TEMPERATURE; ETHANOL; FEVER; MALE; MOTOR ACTIVITY; N-METHYL-3,4-METHYLENEDIOXYAMPHETAMINE; RATS; RATS, LONG-EVANS;

EID: 33745699098     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2006.04.023     Document Type: Article

References (34)

1. 3H]5-HT high-affinity uptake by rat forebrain synaptosomes: role of 5-HT receptors and voltage channel blockers. Brain Res 544 (1991) 243-247
2. Cassel J.C., Jeltsch H., Koenig J., and Jones B.C. Locomotor and pyretic effects of MDMA-ethanol associations in rats. Alcohol 34 (2004) 285-289
3. Cassel J.C., Riegert C., Rutz S., Koenig J., Rothmaier K., Cosquer B., et al. Ethanol, 3,4-methylenedioxymethamphetamine (ecstasy) and their combination: long-term behavioral, neurochemical and neuropharmacological effects in the rat. Neuropsychopharmacology 30 (2005) 1870-1882
4. Chan A.W., and York J.L. Influence of age on the development of rapid tolerance to ethanol. Pharmacol Biochem Behav 47 (1994) 567-573
5. Colado M.I., Esteban B., O'Shea E., Granados R., and Green A.R. Studies on the neuroprotective effect of pentobarbitone on MDMA-induced neurodegeneration. Psychopharmacology 142 (1999) 421-425
6. Cole J.C., and Sumnall H.R. The pre-clinical behavioural pharmacology of 3,4-methylenedioxymethamphetamine (MDMA). Neurosci Biobehav Rev 27 (2003) 199-217
7. De la Torre R., and Farre M. Neurotoxicity of MDMA (ecstasy): the limitations of scaling from animals to humans. TIPS 25 (2004) 505-508
8. Easton N., and Marsden C.A. Ecstasy: are animal data consistent between species and can they translate to humans?. Psychopharmacology 20 (2006) 194-210
9. Farfel G.M., and Seiden L.S. Role of hypothermia in the mechanism of protection against serotonergic toxicity: I. Experiments using 3,4-methylenedioxymethamphetamine, dizocilpine, CGS 19755 and NBQX. JPET 272 (1995) 860-867
10. Green A.R., Cross A.J., and Goodwin G.M. Review of the pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA or "ecstasy"). Psychopharmacology 119 (1995) 247-260
11. Green A.R., Mechan A.O., Elliott J.M., O'Shea E., and Colado M.I. The pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy"). Pharmacol Rev 55 (2003) 463-508
12. Green A.R., O'shea E., and Colado M.I. A review of the mechanisms involved in the acute MDMA (ecstasy)-induced hyperthermic response. Eur J Pharmacol 500 (2004) 3-13
13. Hernandez-Lopez C., Farre M., Roset P.N., Menoyo E., Pizarro N., Ortuno J., et al. 3,4-Methylenedioxymethamphetamine (ecstasy) and alcohol interactions in humans: psychomotor performance, subjective effects, and pharmacokinetics. JPET 300 (2002) 236-244
14. Johnson C.S., Hanson G.R., and Gibb J.W. Body temperature effect on methylenedioxymethamphetamine-induced acute decrease in tryptophan hydroxylase activity. Eur J Pharmacol 293 (1995) 447-453
15. Johnson E.A., O'Callaghan J.P., and Miller D.B. Brain concentrations of d-MDMA are increased after stress. Psychopharmacology 173 (2004) 278-286
16. Khanna J.M., Shah G., Weiner J., Wu P.H., and Kalant H. Effect of NMDA receptor antagonists on rapid tolerance to ethanol. Eur J Pharmacol 230 (1993) 23-31
17. Khanna J.M., Chau A., and Shah G. Characterization of the phenomenon of rapid tolerance to ethanol. Alcohol 13 (1996) 621-628
18. Lograno D.E., Matteo F., Trabucchi M., Govoni S., Cagiano R., Lacomba C., et al. Effects of chronic ethanol intake at a low dose on the rat brain dopaminergic system. Alcohol 10 (1993) 45-49
19. Lora-Tamayo C., Tena T., Rodriguez A., Moreno D., Sancho J.R., Ensenat P., et al. The designer drug situation in Ibiza. Forensic Sci Int 140 (2004) 195-206
20. Maiya R., Buck K.J., Harris R.A., and Mayfield R.D. Ethanol-sensitive sites on the human dopamine transporter. J Biol Chem 277 (2002) 30724-30729
21. Malberg J.E., and Seiden L.S. Small changes in ambient temperature cause large changes in 3,4-methylenedioxymethamphetamine (MDMA)-induced serotonin neurotoxicity and core body temperature in the rat. J Neurosci 18 (1998) 5086-5094
22. Malberg J.E., Sabol K.E., and Seiden L.S. Co-administration of MDMA with drugs that protect against MDMA neurotoxicity produces different effects on body temperature in the rat. J Pharmacol Exp Ther 278 (1996) 258-267
23. Mayfield R.D., Maiya R., Keller D., and Zahniser N.R. Ethanol potentiates the function of the human dopamine transporter expressed in Xenopus oocytes. J Neurochem 79 (2001) 1070-1079
24. Mullin M.J., and Ferko A.P. Alterations in dopaminergic function after subacute ethanol administration. JPET 225 (1983) 694-698
25. Myers R.D. Alcohol's effect on body temperature: hypothermia, hyperthermia or poikilothermia?. Brain Res Bull 7 (1981) 209-220
26. Pan W.J., and Hedaya M.A. Cocaine and alcohol interactions in the rat: effect on cocaine pharmacokinetics and pharmacodynamics. J Pharm Sci 88 (1999) 459-467
27. Parrott A.C. Chronic tolerance to recreational MDMA (3,4-methylenedioxymethamphetamine) or ecstasy. J Psychopharmacol 19 (2005) 71-83
28. Pedersen W., and Skrondal A. Ecstasy and new patterns of drug use: a normal population study. Addiction 94 (1999) 1695-1706
29. Sanchez V., O'shea E., Saadat K.S., Elliott J.M., Colado M.I., and Green A.R. Effect of repeated ('binge') dosing of MDMA to rats housed at normal and high temperature on neurotoxic damage to cerebral 5-HT and dopamine neurones. J Psychopharmacol 18 (2004) 412-416
30. Schifano F. A bitter pill. Overview of ecstasy (MDMA, MDA) related fatalities. Psychopharmacology 173 (2004) 242-248
31. Scholey A.B., Parrott A.C., Buchanan T., Heffernan T.M., Ling J., and Rodgers J. Increased intensity of ecstasy and polydrug usage in the more experienced recreational ecstasy/MDMA users: a WWW study. Addict Behav 29 (2004) 743-752
32. Taffe M.A., Weed M.R., Davis S.A., Huitron-Resendiz S., Schroeder R., Parsons L.H., et al. Functional consequences of repeated (±)3,4-methylenedioxymethamphetamine (MDMA) treatment in rhesus monkeys. Neuropsychopharmacology 24 (2001) 230-239
33. Taffe M.A., Lay C.C., Von Huben S.N., Davis S.A., Crean R.D., and Katner S.N. Hyperthermia induced by 3,4-methylenedioxymethamphetamine in unrestrained rhesus monkeys. Drug Alcohol Depend 82 (2006) 276-281
34. Winer B.J. Statistical principles in experimental design (1971), McGraw-Hill, New York