The in vitro micronucleus test: From past to future

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 607, Issue 1, 2006, Pages 2-4

  Decordier, Ilse ^a   Kirsch Volders, Micheline ^a  

^a VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MARROW CELL; CANCER RISK; CENTROMERE; CHROMOSOME ABERRATION; CHROMOSOME BREAKAGE; CLINICAL PROTOCOL; COLON ADENOMA; COLORECTAL CANCER; CYTOKINESIS; EDITORIAL; FEULGEN STAINING; GENOTOXICITY; IN VITRO STUDY; MEIOTIC PROPHASE I; MICRONUCLEUS; MICRONUCLEUS TEST; MITOSIS RATE; PRIORITY JOURNAL; RETICULOCYTE COUNT; RISK ASSESSMENT; TELOPHASE;

ANIMALS; HISTORY, 19TH CENTURY; HISTORY, 20TH CENTURY; HISTORY, 21ST CENTURY; HUMANS; MICRONUCLEUS TESTS;

EID: 33745684858     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2006.04.008     Document Type: Editorial

References (27)

1. Thoday J.M. The effect of ionizing radiation on the broad bean root. Part IX. Chromosome breakage and the lethality of ionizing radiations to the root meristem. Br. J. Radiol. 24 (1951) 276-572
2. Evans H.J., Neary G.J., and Williamson F.S. The relative biological efficiency of single doses of fast neutrons and gamma rays in Vicia faba roots and the effect of oxygen. Part II. Chromosome damage; the production of micronuclei. Int. J. Rad. Biol. 1 (1959) 230-240
3. Boller K., and Schmid W. Chemical mutagenesis in mammals. The Chinese hamster bone marrow as an in vivo test system. Hematological findings after treatment with trenimon. Humangenetik 11 1 (1970) 35-54
4. Heddle J.A. A rapid in vivo test for chromosome damage. Mutat. Res. 18 (1973) 187-190
5. Countryman P.I., and Heddle J.A. The production of micronuclei from chromosome aberrations in irradiated cultures of human lymphocytes. Mutat. Res. 41 (1976) 321-332
6. Fenech M., and Morley A.A. Cytokinesis-block micronucleus method in human lymphocytes: effect of in vivo ageing and low dose X-irradiation. Mutat. Res. 161 (1986) 193-198
7. Eastmond D.A., and Tucker J.D. Identification of aneuploidyinducing agents using cytokinesis-blocked human lymphocytes and an antikinetochore antibody. Environ. Mol. Mutagen. 13 (1989) 34-43
8. Eastmond D.A., and Pinkel D. Detection of aneuploidy and aneuploidy-inducing agents in human lymphocytes using fluorescence in situ hybridization with chromosome-specific DNA probes. Mutat. Res. 234 (1990) 9-20
9. Miller B.M., Zitzelsberger H., Weier H.-U., and Adler I.-D. Classification of micronuclei in murine erythrocytes:immunofluorescent staining using CREST antibodies compared to in situ hybridization with biotinylated satellite DNA. Mutagenesis 6 (1991) 297-302
10. Farooqi Z., Darroudi F., and Natarajan A.T. The use of fluorescence in situ hybridization for the detection of aneugens in cytokinesis-blocked mouse splenocytes. Mutagenesis 8 (1993) 329-334
11. Migliore, Bocciardi R., Macri C., and Lo Jacono F. Cytogenetic damage induced in human lymphocytes by four vanadium compounds and micronucleus analysis by fluorescence in situ hybridization with a centromeric probe. Mutat. Res. 319 (1993) 205-213
12. Norppa H., Renzi L., and Lindholm C. Detection of whole chromosomes in micronuclei of cytokinesis-blocked human lymphocytes by antikinetochore staining and in situ hybridization. Mutagenesis 8 (1993) 519-525
13. Eastmond D.A., Rupa D.A., and Hasegawa L.S. Detection of hyperploidy and chromosome breakage in interphase in human lymphocytes following exposure to the benzene metabolite hydroquinone using multicolor fluorescence in situ hybridization with DNA probes. Mutat. Res. 322 (1994) 9-20
14. Kirsch-Volders M., Elhajouji A., Cundari E., and Van Hummelen P. The in vitro micronucleus test: a multi-endpoint assay to detect simultaneously mitotic delay, apoptosis, chromosome breakage, chromosome loss and non-disjunction. Mutat. Res. 392 (1997) 19-30
15. Fenech M., Perepetskaya G., and Mikhalevich L. A more comprehensive application of the micronucleus technique for biomonitoring of genetic damage rates in human populations-experiences from the Chernobyl catastrophe. Environ. Mol. Mutagen. 30 (1997) 112-118
16. Elhajouji A., Van Hummelen P., and Kirsch-Volders M. Indications for a threshold of chemically-induced aneuploidy in vitro in human lymphocytes. Environ. Mol. Mutagen. 26 (1995) 292-304
17. Elhajouji A., Tibaldi F., and Kirsch-Volders M. Indication for thresholds of chromosome non-disjunction versus chromosome lagging induced by spindle inhibitors in vitro in human lymphocytes. Mutagenesis 12 (1997) 133-140
18. Kirsch-Volders M., Sofuni T., Aardema M., Albertini S., Eastmond D., Fenech M., Ishidate Jr. M., Lorge E., Norppa H., Surrallés J., von der Hude W., and Wakata A. Report from the in vitro micronucleus assay working group. Environ. Mol. Mutagen. 35 (2000) 167-172
19. Kirsch-Volders M., Sofuni T., Aardema M., Albertini S., Eastmond D., Fenech M., Ishidate Jr. M., Kirchner S., Lorge E., Morita T., Norppa H., Surrallés J., Vanhauwaert A., and Wakata A. Report from the in vitro micronucleus assay working group. Mutat. Res. 540 (2003) 153-163 (Erratum in: Mutat Res. 2004 Nov;564 (1):97-100)
20. M. Kirsch-Volders, R.A. Mateuca, M. Roelants, A. Tremp, E. Zeiger, S. Bonassi, N. Holland, W. P. Chang, P.V. Aka, M. De Boeck, L. Godderis, V. Haufroid, H. Ishikawa, B. Laffon, R. Marcos, L. Migliore, H. Norppa, J. P. Teixeira, A. Zijno, M. Fenech, The effects GSTM1 and GSTT1 polymorphisms on micronucleus frequencies in human lymphocytes in vivo. Cancer Epidemiol. Biomark Prevent.2006 in press.
21. Hagmar L., Bonassi S., Stromberg U., Brogger A., Knudsen L.E., Norppa H., and Reuterwall C. Chromosomal aberrations in lymphocytes predict human cancer: a report from the European study group on cytogenetic biomarkers and health (ESCH). Cancer Res. 58 18 (1998) 4117-4121
22. Albertini S., Miller B., Chételat A., and Locher F. Detailed data on in vitro MNT and in vitro CA: industrial experience. Mutat. Res. 392 (1997) 187-208
23. Miller B., Albertini S., Locher F., Thybaud V., and Lorge E. Comparative evaluation of the in vitro micronucleus test and the in vitro chromosome aberration test: industrial experience. Mutat. Res. 392 (1997) 45-59
24. Miller B., Pötter-Locher F., Seelbach A., Stopper H., Utesch D., and Madle S. Evaluation of the in vitro chromosomal aberration assay: position of the GUM working group on the in vitro micronucleus test. Mutat. Res. 410 (1998) 81-116
25. Guzmán P., Sotelo-Regil R.C., Mohar A., and Gonsebatt M.E. Positive correlation between the frequence of micronucleated cells and dysplasia in papanicolaou smears. Environ. Mol. Mut. 41 (2003) 339-343
26. Olaharski A., Sotelo R., Solorza-Luna G., Gonsebatt M.E., Guzman P., Mohar A., and Eastmond D.A. Tetraploidy and chromosomal instability are early events during cervical carcinogenesis. Carcinogenesis 27 (2006) 3317-3343
27. Rajagoplalan H., Jallepalli P.V., Rago C., Velculescu V.E., Kinzler K.W., Vogelstein B., and Lengauer C. Inactivation of hCDC4 can cause chromosomal instability. Nature 428 (2004) 77-81