Increased Ki-67 proliferative index and absence of P16INK4 in CIN-HPV related pathogenic pathways different from cervical squamous intraepithelial lesion

British Journal of Ophthalmology

Volumn 90, Issue 7, 2006, Pages 894-899

  Kuo, K T ^b   Chang, H C ^a   Hsiao, C H ^b   Lin, Ming Chieh ^b  

^a TAIPEI HOSPITAL   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE PROTEIN; KI 67 ANTIGEN; PROTEIN P16INK4A; PROTEIN P53; RETINOBLASTOMA PROTEIN;

ADOLESCENT; ADULT; AGED; ARTICLE; CANCER GRADING; CLINICAL ARTICLE; CONJUNCTIVA EPITHELIUM; CONJUNCTIVA TUMOR; CONTROLLED STUDY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; PATHOGENESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENSITIVITY ANALYSIS; SQUAMOUS EPITHELIUM; UTERINE CERVIX CARCINOMA IN SITU; VIRUS DETECTION; VIRUS INFECTION; WART VIRUS;

ADOLESCENT; ADULT; AGED; CARCINOMA IN SITU; CELL PROLIFERATION; CERVICAL INTRAEPITHELIAL NEOPLASIA; CHI-SQUARE DISTRIBUTION; CONJUNCTIVAL NEOPLASMS; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DNA, VIRAL; EPITHELIAL CELLS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; MALE; MIDDLE AGED; PAPILLOMAVIRIDAE; PAPILLOMAVIRUS INFECTIONS; POLYMERASE CHAIN REACTION; TUMOR MARKERS, BIOLOGICAL; UTERINE CERVICAL NEOPLASMS;

EID: 33745668643     PISSN: 00071161     EISSN: None     Source Type: Journal    
DOI: 10.1136/bjo.2005.086314     Document Type: Article

References (48)

1. Grossniklaus HE, Green WR, Luckenbach M, et al. Conjunctival lesions in adults. A clinical and histopathologic review. Cornea 1987;6:78-116.
2. Ni C, Searl SS, Kriegstein HJ, et al. Epibulbar carcinoma. Int Ophthalmol Clin 1982;22:1-33.
3. Ash JE. Epibulbar tumors. Am J Ophthalmol 1950;33:1203-19.
4. Walboomers JMM, Jacobs MV, Manos MM, et al. Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol 1999;189:12-19.
5. Zur Hausen H. Papillomavirus infections-a major cause of human cancers. Biochim Biophys Acta 1996;1288:55-78.
6. Koutsky LA, Holmes KK, Critchlow CW, et al. A cohort study of the risk of cervical intraepithelial neoplasia grade 2 or 3 in relation to papillomavirus infection. N Engl J Med 1992;327:1272-8.
7. Johnson MA, Blomfield PI, Bevan IS, et al. Analysis of human papillomavirus type 16 E6-E7 transcription in cervical carcinomas and normal cervical epithelium using the polymerase chain reaction. J Gen Virol 1990;71:1473-9.
8. Young LS, Bevan IS, Johnson MA, et al. The polymerase chain reaction: a new epidemiological tool for investigating cervical human papillomavirus infection. Br Med J 1989;298:14-18.
9. Howley PM, Schlegel R. The human papillomaviruses. An overview. Am J Med 1988;85:155-8.
10. Walker PG, Singer A, Dyson JL, et al. The prevalence of human papillomavirus antigen in patients with cervical intra-epithelial neoplasia. Br J Cancer 1983;48:99-101.
11. Tringler B, Gup CJ, Singh M, et al. Evaluation of p16INK4a and pRb expression in cervical squamous and glandular neoplasia. Human Pathol 2004;35:689-96.
12. Odrich MG, Jakobiec FA, Lancaster WD, et al. A spectrum of bilateral squamous conjunctival tumors associated with human papillomavirus type 16. Ophthalmology 1991;98:628-35.
13. Karcioglu ZA, Issa TM. Human papilloma virus in neoplastic and nonneoplastic conditions of the external eye. Br J Ophthalmol 1997;81:595-8.
14. Lauer SA, Malter JS, Meier JR. Human papillomavirus type 18 in conjunctival intraepithelial neoplasia. Am J Ophthalmol 1990;110:23-7.
15. McDonnell JM, Mayr AJ, Martin WJ. DNA of human papillomavirus type 16 in dysplastic and malignant lesions of the conjunctiva and cornea. N Engl J Med 1989;320:1442-6.
16. Stanley MA. Human papillomavirus and cervical carcinogenesis. Best Pract Res Clin Obstet Gynaecol 2001;15:663-76.
17. Vogelstein B, Lane D, Levine AJ. Surfing the p53 network. Nature 2000;408:307-10.
18. Shields JA, Shields CL. Tumors of the conjunctiva and cornea. In: Smolin G, eds. The cornea:scientific foundations and clinical practice. 3rd ed. Boston: Little, Brown, 1994:586-8.
19. Tune M, Char DM, Crawford B, et al. Intraepithelial and invasive squamous cell carcinoma of the conjunctiva: analysis of 60 cases. Br J Ophthalmol 1999;83:98-103.
20. Bauer HM, Greer CE, Manos MM. Determination of genital human papillomavirus infection by consensus PCR amplification. In: Herrington CS, eds. Diagnostic molecular pathology: a practical approach. Vol 2. Oxford: Oxford University Press, 1992.
21. Gerdes J, Lemke H, Baisch H, et al. Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. J Immunol 1984;133:1710-15.
22. Lu S, Tiekso J, Hietanen S, et al. Expression of cell-cycle proteins p53, p21 (WAF-1), PCNA and Ki67 in benign, premalignant and malignant skin lesions with implicated HPV involvement. Acta Derm Venereol 1999;79:268-73.
23. Rudolph P, Peters J, Lorenz D, et al. Correlation between mitotic and Ki-67 labeling indices in paraffin-embedded carcinoma specimens. Hum Pathol 1998;29:1216-22.
24. McCluggage WG, Maxwell P, Bharucha H. Immunohistochemical detection of metallothionein and MIB1 in uterine cervical squamous lesions. Int J Gynecol Pathol 1998;17:29-35.
25. Ohara M, Sotozono C, Tsuchihashi Y, et al. Ki-67 labeling index as a marker of malignancy in ocular surface neoplasms. Jpn J Ophthalmol 2004;48:524-9.
26. Zitz JC, McLachlin CM, Tate JE, et al. Restriction fragment length polymorphism analysis of isotype-labeled polymerase chain reaction-amplified human papillomavirus DNA combines sensitivity with built-in contaminant detection. Mod Pathol 1994;7:407-11.
27. Feoli-Fonseca JC, Oligny LL, Filion M, et al. Direct human papillomavirus (HPV) sequencing method yields a novel HPV in a human immunodeficiency virus-positive Quebec woman and distinguishes a new HPV clade. J Infect Dis 1998;178:1492-6.
28. Feoli-Fonseca K, Oligny LL, Filion M, et al. A two-tier polymerase chain reaction direct sequencing method for detecting and typing human papillomaviruses in pathological specimens. Diagn Mol Pathol 1998;7:317-23.
29. Feoli-Fonseca JC, Oligny LL, Filion M, et al. A putative novel human papillomavirus identified by PCR-DS. Biochem Biophys Res Commun 1998;250:63-7.
30. Jacobs MV, Snijders PJ, van den Brule AJ, et al. A general primer GP5+/GP6(+)-mediated PCR-enzyme immunoassay method for rapid detection of 14 high-risk and 6 low-risk human papillomavirus genotypes in cervical scrapings. J Clin Microbiol 1997;35:791-5.
31. Huang HJ, et al. Human papillomavirus genotyping by a polymerase chain reaction-based genechip method in cervical carcinoma treated with neoadjuvant chemotherapy plus radical surgery. Int J Gynecol Cancer 2004;14:639-49.
32. Tulvatana W, Bhattarakosol P, Sansopha L, et al. Risk factors for conjunctival squamous cell neoplasia:a matched case-control study. Br J Ophthalmol 2003;87:396-8.
33. Scott IU, Karp CL, Nuovo GJ. Human papillomavirus 16 and 18 expression in conjunctival intraepithelial neoplasia. Ophthalmology 2002;109:542-7.
34. Munoz N, Bosch FX, de Sanjose S, et al. Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med 2003;348:518-27.
35. Brehm A, Kouzarides T. Retinoblastoma protein meets chromatin. Trends Biochem Sci 1999;24:142-5.
36. Jones DL, Munger K. Interactions of the human papillomavirus E7 protein with cell cycle regulators. Semin Cancer Biol 1996;7:327-37.
37. Milde-Langosch K, Schreiber C, Becker G, et al. Human papillomavirus detection in cervical adenocarcinomas by polymerase chain reaction. Hum Pathol 1993;24:590-4.
38. Zhang HS, Postigo AA, Dean DC. Active transcriptional repression by the Rb-E2F complex mediates G1 arrest triggered by p16INK4a, TGFbeta, and contact inhibition. Cell 1999;97:53-61.
39. Stoler MH. Human papillomavirus and cervical neoplasia: a model for carcinogenesis. Int J Gynecol Pathol 2000;19:16-28.
40. Zerfass-Thome K, Zwerschke W, Mannhardt B, et al. Inactivation of the cdk inhibitor p27KIP1 by the human papillomavirus type 16 E7 oncoprotein. Oncogene 1996;13:2323-30.
41. zur Hausen H. Molecular pathogenesis of cancer of the cervix and its causation by specific human papillomavirus types. Curr Top Microbiol Immunol 1994;186:131-56.
42. Dyson N, Howley PM, Munger K, et al. The human papilloma virus-16 E7 oncoprotein is able to bind the retinoblastoma gene product. Science 1989;243:934-40.
43. Sherr CJ. Cancer cell cycles. Science 1996;274:1672-7.
44. Kamb A, Gruis NA, Weaver-Feldhaus J, et al. A cell cycle regulator potentially involved in genesis of many tumor types. Science 1994;264:436-40.
45. Khleif SN, DeGregori J, Yee CL, et al. Inhibition of cyclin D-CDK4/CDK6 activity is associated with an E2F-mediated induction of cyclin kinase inhibitor activity. Proc Natl Acad Sci USA 1996;93:4350-4.
46. Ansai S, Koseki S, Hozumi Y, et al. Assessment of cellular proliferation of sebaceous neoplasms by AgNOR counts and immunohistochemical demonstrations of PCNA and Ki-67. J Dermatol 1995;22:238-48.
47. Hall PA, Levison DA, Woods AL, et al. Proliferating cell nuclear antigen (PCNA) immunolocalization in paraffin sections: an index of cell proliferation with evidence of deregulated expression in some neoplasms. J Pathol 1990;162:285-94.
48. Mahomed A, Chetty R. Human immunodeficiency virus infection, Bcl-2, p53 protein, and Ki-67 analysis in ocular surface squamous neoplasia. Arch Ophthalmol 2002;120:554-8.