New targets for modifying mast cell activation in asthma

Current Allergy and Asthma Reports

Volumn 6, Issue 3, 2006, Pages 247-251

  Ennis, Madeleine ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE A2B RECEPTOR; ADENOSINE RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CHEMOKINE RECEPTOR CCR1; CHEMOKINE RECEPTOR CCR4; CHEMOKINE RECEPTOR CXCR3; CROMOGLYCATE DISODIUM; CYTOKINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IMMUNOGLOBULIN E ANTIBODY; LEUKOTRIENE RECEPTOR BLOCKING AGENT; MEVINOLIN; N (1 HYDROXY 2 NAPHTHOYL)ARGINYLPROLINAMIDE; NEDOCROMIL SODIUM; PROTEINASE ACTIVATED RECEPTOR 2; SIMVASTATIN; STEROID; TOLL LIKE RECEPTOR; TRYPTASE INHIBITOR;

ALLERGIC ASTHMA; ANTIINFLAMMATORY ACTIVITY; ASTHMA; BRONCHOSPASM; BRONCHUS HYPERREACTIVITY; CELL ACTIVATION; CHRONIC INFLAMMATION; CLINICAL TRIAL; DRUG MECHANISM; DRUG TARGETING; EOSINOPHILIA; HUMAN; LUNG ALVEOLUS CELL; MAST CELL; MAST CELL DEGRANULATION; NONHUMAN; REVIEW; SMOOTH MUSCLE;

ANIMALS; ASTHMA; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MAST CELLS; MUSCLE, SMOOTH; RECEPTORS, PURINERGIC P1; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; TOLL-LIKE RECEPTORS; TRYPTASES;

EID: 33745649567     PISSN: 15297322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11882-006-0042-3     Document Type: Review

References (46)

1. Global Initiative for Asthma Global Strategy for Asthma Management and Prevention: (Updated 2005). http://www.ginasthma.com/. Accessed December 15, 2006.
2. Scola AM, Chong LK, Suvarna SK, et al.: Desensitisation of mast cell beta2-adrenoceptor-mediated responses by salmeterol and formoterol. Br J Pharmacol 2004, 141:163-171.
3. Da Silva CA, Frossard N: Potential role of stem cell factor in the asthma control by glucocorticoids. Chem Immunol Allergy 2005, 87:154-162.
4. Cohan VL, Undem BJ, Fox CC, et al.: Dexamethasone does not inhibit the release of mediators from human mast cells residing in airway, intestine, or skin. Am Rev Respir Dis 1989, 140:951-954.
5. Zhao Y, Leung PC, Woo KS, et al.: Inhibitory effects of budesonide, desloratadine and dexamethasone on cytokine release from human mast cell line (HMC-1). Inflamm Res 2004, 53:664-669.
6. Pearce FL, Ali H, Barrett KE, et al.: Functional characteristics of mucosal and connective tissue mast cells of man, the rat and other animals. Int Arch Allergy Appl Immunol 1985, 77:274-276.
7. Leung KB, Flint KC, Brostoff J, et al.: Effects of sodium cromoglycate and nedocromil sodium on histamine secretion from human lung mast cells. Thorax 1988, 43:756-761.
8. Cushley MJ, Tattersfield AE, Holgate ST: Inhaled adenosine and guanosine on airway resistance in normal and asthmatic subjects. Br J Clin Pharmacol 1983, 15:161-165.
9. Fozard JR: The case for a role for adenosine in asthma: almost convincing? Curr Opin Pharmacol 2003, 3:264-269.
10. Holgate ST: The identification of the adenosine A2B receptor as a novel therapeutic target in asthma. Br J Pharmacol 2005, 145:1009-1015.
11. Livingston M, Heaney LG, Ennis M: Adenosine, inflammation and asthma - a review. Inflamm Res 2004, 53:171-178.
12. Richards R, Phillips GD, Holgate ST: Nedocromil sodium is more potent than sodium cromoglycate against AMP induced bronchoconstriction in atopic asthmatic subjects. Clin Exp Allergy 1989, 19:285-291.
13. Hughes PJ, Holgate ST, Church MK: Adenosine inhibits and potentiates IgE-dependent histamine release from human lung mast cells by an A2-purinoceptor mechanism. Biochem Pharmacol 1984, 33:3847-3852.
14. Peachell PT, Columbo M, Kagey-Sobotka A, et al.: Adenosine potentiates mediator release from human lung mast cells. Am Rev Respir Dis 1988, 138:1143-1151.
15. Forsythe P, Mc Garvey LPA, Heaney LG, et al.: Adenosine induces histamine release from human bronchoalveolar lavage mast cells. Clin Sci 1999, 96:349-355.
16. Feoktistov I, Biaggioni I: Adenosine A2b receptors evoke interleukin-8 secretion in human mast cells. An enprofylline-sensitive mechanism with implications for asthma. J Clin Invest 1995, 96:1979-1986.
17. Zhong H, Chunn JL, Volmer JB, et al.: Adenosine-mediated mast cell degranulation in adenosine deaminase-deficient mice. J Pharmacol Exp Ther 2001, 298:433-440.
18. Chunn JL, Young HW, Banerjee SK, et al.: Adenosine-dependent airway inflammation and hyperresponsiveness in partially adenosine deaminase-deficient mice. J Immunol 2001, 167:4676-4685.
19. Hart PH: Regulation of the inflammatory response in asthma by mast cell products. Immunol Cell Biol 2001, 79:149-153.
20. He S, Aslam A, Gaca MD, et al.: Inhibitors of tryptase as mast cell-stabilizing agents in the human airways: effects of tryptase and other agonists of proteinase-activated receptor 2 on histamine release. J Pharmacol Exp Ther 2004, 309:119-126.
21. Schmidlin F, Amadesi S, Vidil R, et al.: Expression and function of proteinase-activated receptor 2 in human bronchial smooth muscle. Am J Respir Crit Care Med 2001, 164:1276-1281.
22. Knight DA, Lim S, Scaffidi AK, et al.: Protease-activated receptors in human airways: upregulation of PAR-2 in respiratory epithelium from patients with asthma. J Allergy Clin Immunol 2001, 108:797-803.
23. Schmidlin F, Amadesi S, Dabbagh K, et al.: Protease-activated receptor 2 mediates eosinophil infiltration and hyperreactivity in allergic inflammation of the airway. J Immunol 2002, 169:5315-5321.
24. Cairns JA: Inhibitors of mast cell tryptase beta as therapeutics for the treatment of asthma and inflammatory disorders. Pulm Pharmacol Ther 2005, 18:55-66.
25. Brightling CE, Bradding P, Symon FA, et al.: Mast-cell infiltration of airway smooth muscle in asthma. N Engl J Med 2002, 346:1699-1705.
26. Carroll NG, Mutavdzic S, James AL: Distribution and degranulation of airway mast cells in normal and asthmatic subjects. Eur Respir J 2002, 19:879-885.
27. Amin K, Janson C, Boman G, et al.: The extracellular deposition of mast cell products is increased in hypertrophic airways smooth muscles in allergic asthma but not in non-allergic asthma. Allergy 2005, 60:1241-1247.
28. Berger P, Girodet PO, Begueret H, et al.: Tryptase-stimulated human airway smooth muscle cells induce cytokine synthesis and mast cell chemotaxis. FASEB J 2003, 17:2139-2141.
29. Brightling CE, Kaur D, Berger P, et al.: Differential expression of CCR3 and CXCR3 by human lung and bone marrow-derived mast cells: implications for tissue mast cell migration. J Leuk Biol 2005, 77:S759-S66.
30. Brightling CE, Ammit AJ, Kaur D, et al.: The CXCL10/CXCR3 axis mediates human lung mast cell migration to asthmatic airway smooth muscle. Am J Respir Crit Care Med 2005, 171:1103-1108.
31. Amin K, Janson C, Harvima I, et al.: CC chemokine receptors CCR1 and CCR4 are expressed on airway mast cells in allergic asthma. J Allergy Clin Immunol 2005, 116:1383-1385.
32. Scott K, Bradding P: Human mast cell chemokines receptors: implications for mast cell tissue localization in asthma. Clin Exp Allergy 2005, 35:693-697.
33. Johnston SL: Viruses and asthma. Allergy 1998, 53:922-932.
34. Chaudhuri N, Dower SK, Whyte MK, et al.: Toll-like receptors and chronic lung disease. Clin Sci (Lond) 2005, 109:125-133.
35. Kulka M, Metcalfe DD: TLR3 activation inhibits human mast cell attachment to fibronectin and vitronectin. Mol Immunol 2005, [Epub ahead of print].
36. Marone G, Rossi FW, Bova M, et al.: Superallergens: a novel mechanism of IgE-mediated activation of human basophils and mast cells. Clin Exp Allergy Reviews 2004, 4:64-75.
37. Varadaradjalou S, Feger F, Thieblemont N, et al.: Toll-like receptor 2 (TLR2) and TLR4 differentially activate human mast cells. Eur J Immunol 2003, 33:899-906.
38. Kulka M, Alexopoulou L, Flavell RA, et al.: Activation of mast cells by double-stranded RNA: evidence for activation through Toll-like receptor 3. J Allergy Clin Immunol 2004, 114:174-182.
39. Okumura S, Kashiwakura J-I, Tomita H, et al.: Identification of specific gene expression profiles in human mast cells mediated by Toll-like receptor 4 and FcepsilonRI. Blood 2003, 102:2547-2554.
40. Shakarjian MP, Eiseman E, Penhallow RC, et al.: 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibition in a rat mast cell line. Impairment of tyrosine kinase-dependent signal transduction and the subsequent degranulation response. J Biol Chem 1993, 268:15252-15259.
41. Roche CM, Trimble ER, Ennis M: Effect of in vivo and in vitro lovastatin treatment on mast cell activation. Int Arch Allergy Immunol 1995, 108:240-246.
42. Veillard NR, Braunersreuther V, Arnaud C, et al.: Simvastatin modulates chemokine and chemokine receptor expression by geranylgeranyl isoprenoid pathway in human endothelial cells and macrophages. Atherosclerosis 2005, [Epub ahead of print].
43. Lee JH, Lee DS, Kim EK, et al.: Simvastatin inhibits cigarette smoking-induced emphysema and pulmonary hypertension in rat lungs. Am J Respir Crit Care Med 2005, 172:987-993.
44. Jacobson JR, Barnard JW, Grigoryev DN, et al.: Simvastatin attenuates vascular leak and inflammation in murine inflammatory lung injury. Am J Physiol Lung Cell Mol Physiol 2005, 288:L1026-L1032.
45. McKay A, Leung BP, McInnes IB, et al.: A novel anti-inflammatory role of simvastatin in a murine model of allergic asthma. J Immunol 2004, 172:2903-2908.
46. Weitz-Schmidt G: Statins as anti-inflammatory agents. Trends Pharmacol Sci 2002, 10:482-486.