Altered expression of DNA double-strand repair genes Ku70 and Ku80 in carcinomas of the oral cavity

Anticancer Research

Volumn 26, Issue 3 A, 2006, Pages 2101-2105

  Korabiowska, Monika ^a,f   Voltmann, Jann ^a   Hönig, Johannes F ^b   Bortkiewicz, Pawel ^c   König, Frank ^a   Cordon Cardo, Carlos ^d   Jenckel, Frederike ^e   Ambrosch, Petra ^e   Fischer, Gösta ^a  

^a UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

^c ADAM MICKIEWICZ UNIVERSITY   (Poland)

^d MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^e UNIVERSITY OF KIEL   (Germany)

^f Institute of Pathology   (Germany)

Author keywords

DNA repair; Ku70; Ku80; Oral cancer

Indexed keywords

DNA DEPENDENT PROTEIN KINASE; KU ANTIGEN; PROTEIN KU80; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CANCER GRADING; CIGARETTE SMOKING; CLINICAL ARTICLE; FEMALE; HUMAN; LYMPH NODE METASTASIS; MALE; MOUTH CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR GROWTH;

ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, NUCLEAR; CARCINOMA, SQUAMOUS CELL; DNA REPAIR; DNA, NEOPLASM; DNA-BINDING PROTEINS; FEMALE; HUMANS; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; MOUTH NEOPLASMS; NEOPLASM STAGING; SMOKING;

EID: 33745620456     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Gao Y, Chandhuri J, Zhu C, Davidson L, Weaver DT and Alt FW: A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for Ku in V(D)J recombination. Immunity 9: 367-376, 1999.
2. Jeggo PA: Identification of genes involved in repair of DNA double-strand breaks in mammalian cells. Radiat Res 150: S80-91, 1998.
3. Muller C, Rodrigo G, Calsou P and Sales B: DNA-dependent protein kinase: a major protein involved in the cellular response to ionizing radiation. Bull Cancer 86: 977-983, 1999.
4. Kumaravel TS, Bharathy K, Kudoh S, Tanaka K and Kamada N: Expression, localisation and functional interactions of Ku70 subunit of DNA-PK in peripheral lymphocytes and Nalm-19 cells after irradiation. Int J Radiat Biol 74: 481-489, 1998.
5. Takata M, Sasaki MS, Sonoda E, Morrison C, Hashimoto M and Utsumi H: Homologous recombination and nonhomologous end-joining pathways of DNA double strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells. EMBO J 17: 5497-5508, 1998.
6. Collis SJ, DeWeese TL, Jeggo PA and Parker AR: The life and death of DNA-PK. Oncogene 24: 949-961, 2005.
7. Li GC, Ouyang H, Li X, Nagasawa H, Little JB and Chen DJ: Ku70 a candidate tumor suppressor gene for murine T cell lymphoma. Mol Cell 2: 1-8, 1998.
8. Lee ST, Moore JK, Holmes A, Umezu K, Kolodner RD and Haber JE: Sacharomyces Ku70, mre11/rad50, and RPA proteins regulate adaptation to G2M arrest after DNA damage. Cell 94: 399-409, 1998.
9. Anneroth G, Batsakis J and Luna M: Review of literature and recommended system of malignancy grading in oral squamous cell carcinomas. Scand J Dent Res 95: 229-231, 1987.
10. Hanazawa S: Correlation between histological grading of malignancy of the squamous cell carcinoma of the tongue (by modified Willen's method) and the incidence of cervical lymph node metastasis. J Jpn Soc Cancer Ther 21: 34-37, 1986.
11. Gupta PC, Murti PR and Bhonsle RB: Epidemiology of cancer by tobacco products and the significance of TSNA. Crit Rev Toxicol 26: 183-198, 1996.
12. Idris AM, Ahmed HM and Malik MO: Toombak dipping and cancer of the oral cavity in the Sudan, a case control study. Int J Cancer 63: 477-480, 1995.
13. Znaor A, Brennan P, Gajalakshmi V, Mathew A, Shanta V, Varghese C and Boffetta P: Independent and combined effects of tobacco smoking, chewing, and alcohol drinking on the risk of oral, pharyngeal and esophageal cancers in Indian men. Int J Cancer 105: 681-686, 2003.
14. Raju U, Ariga H, Dittmann K, Nakata E, Ang KK and Milas L: Inhibition of DNA repair as a mechanism of enhanced radioresponse of head and neck carcinoma cells by a selective cyclooxygenase-2 inhibitor-celecoxib. Int J Radiat Oncol Biol Phys 63: 520-528, 2005.
15. Shintani S, Mihara M, Li Ch, Nakahara Y, Hino S, Nakashiro H and Hamakawa H: Upregulation of DNA-dependent protein kinase correlates with radiation resistance in oral squamous cell carcinoma. Cancer Sci 94: 894-900, 2003.
16. Lee SW, Cho KJ, Park JH, Kim SY, Nam SY, Lee BJ, Kim SB, Choi SH, Kim JH, Ahn SD, Shin SS, Choi EK and Yu E: Expression of Ku70 and DNA-PKcs as prognostic indicators of local control in nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys 62: 1451-1457, 2005.
17. Lee KA, Kang JW, Shim JH, Kho CW, Park SG, Lee HG, Paik SG, Lim JS and Yoon DY: Protein profiling and identification of modulators regulated by human papillomavirus 16E7 oncogene in HaCaT keratinocytes by proteomics. Gynecol Oncol 99: 142-152, 2005.