Neuroprotection and enhanced recovery with Hypericum perforatum extract after experimental spinal cord injury in mice

Shock

Volumn 25, Issue 6, 2006, Pages 608-617

  Genovese, Tiziana ^a   Mazzon, Emanuela ^a,b   Menegazzi, Marta ^c   Di Paola, Rosanna ^a   Muià, Carmelo ^a   Crisafulli, Concetta ^a   Bramanti, Placido ^b   Suzuki, Hisanori ^c   Cuzzocrea, Salvatore ^a,b,d  

^a Dipto Clin Sperim Med Farmacol   (Italy)

^b IRCCS CENTRO NEUROLESI BONINO PULEJO   (Italy)

^c UNIVERSITY OF VERONA   (Italy)

^d UNIVERSITY OF MESSINA   (Italy)

Author keywords

Inflammation; Neutrophil infiltration; Oxidative stress; PAR; Polyphenols; STAT 3

Indexed keywords

3 NITROTYROSINE; FLAVONOID; HYPERICUM PERFORATUM EXTRACT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHENOL DERIVATIVE; POLY(ADENOSINE DIPHOSPHATE RIBOSE); STAT3 PROTEIN; 3-NITROTYROSINE; DRUG DERIVATIVE; HYPERICUM EXTRACT LI 160; PLANT EXTRACT; TYROSINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CONVALESCENCE; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DURA MATER; HYPERICUM PERFORATUM; LAMINECTOMY; MALE; MOUSE; MYELITIS; NEUROPROTECTION; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SPINAL CORD INJURY; TISSUE DISTRIBUTION; TISSUE INJURY; ANIMAL; CHEMISTRY; HYPERICUM; INFLAMMATION; METABOLISM; OXIDATIVE STRESS; PATHOLOGY; PHYTOTHERAPY;

ANIMALS; HYPERICUM; INFLAMMATION; MALE; MICE; NEUTROPHIL INFILTRATION; OXIDATIVE STRESS; PHYTOTHERAPY; PLANT EXTRACTS; POLY ADENOSINE DIPHOSPHATE RIBOSE; RECOVERY OF FUNCTION; SIGNAL TRANSDUCTION; SPINAL CORD INJURIES; TYROSINE;

EID: 33745612240     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.shk.0000209560.54328.69     Document Type: Article

References (40)

1. Bartholdi D, Schwab ME: Methylprednisolone inhibits early inflammatory processes but not ischemic cell death after experimental spinal cord lesion in the rat. Brain Res 672:177-186, 1995.
2. Popovich PG, Reinhard JF Jr, Flanagan EM, Stokes BT: Elevation of the neurotoxin quinolinic acid occurs following spinal cord trauma. Brain Res 633:348-352, 1994.
3. Popovich PG, Stokes BT, Whitacre CC: Concept of autoimmunity following spinal cord injury: possible roles for T lymphocytes in the traumatized central nervous system. J Neurosci Res 45:349-363, 1996.
4. Xu J, Kim GM, Chen S, Yan P, Ahmed SH, Ku G, Beckman JS, Xu XM, Hsu CY: iNOS and nitrotyrosine expression after spinal cord injury. J Neurotrauma 18:523-532, 2001.
5. Barnes J, Anderson LA, Phillipson JD: St John's wort (Hypericum perforatum L.): a review of its chemistry, pharmacology and clinical properties. J Pharm 53:583-600, 2001.
6. Saija A, Scalese M, Lanza M, Marzullo D, Bonina F, Castelli F: Flavonoids as antioxidant agents: importance of their interaction with biomembranes. Free Rad Biol Med 19:481-486, 1995.
7. Abd El-Gawad HM, Khalifa AE: Quercetin, coenzyme Q10, and L-canavanine as protective agents against lipid peroxidation and nitric oxide generation in endotoxin-induced shock in rat brain. Pharmacol Res 43:257-263, 2001.
8. Flausino OA Jr, Zangrossi H Jr, Salgado JV, Viana MB: Effects of acute and chronic treatment with Hypericum perforatum L. (LI 160) on different anxiety-related responses in rats. Pharmacol Biochem Behav 71:259-265, 2002.
9. Tedeschi E, Menegazzi M, Margotto D, Suzuki H, Förstermann U, Kleinert H: Anti-inflammatory actions of St. John's wort: inhibition of human inducible nitric-oxide synthase expression by down-regulating signal transducer and activator of transcription-1α (STAT-1) activation. J Pharmacol Exp Ther 307:254-261, 2003.
10. Di Paola R, Muia C, Mazzon E, Genovese T, Crisafulli C, Menegazzi M, Caputi AP, Suzuki H, Cuzzocrea S: Effects of Hypericum perforatum extract in a rat model of ischemia and reperfusion injury. Shock 24:255-263, 2005.
11. Raso GM, Pacilio M, DiCarlo G, Esposito E, Pinto L, Meli R: In vivo and in vitro anti-inflammatory effect of Echinacea purpurea and Hypericum perforatum. J Pharm Pharmacol 54:1379-1383, 2002.
12. Cuzzocrea S, Chatterjee PK, Mazzon E, Dugo L, De Sarro A, Van de Loo FA, Caputi AP, Thiemermann C: Role of induced nitric oxide in the initiation of the inflammatory response after postischemic injury. Shock 8(2):169-176, 2002.
13. Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254, 1976.
14. Cuzzocrea S, Di Paola R, Mazzon E, Genovese T, Muia C, Caputi AP: WY 14643, a potent exogenous PPAR-alpha ligand, reduces intestinal injury associated with splanchnic artery occlusion shock. Shock 22:340-346, 2004.
15. Genovese T, Mazzon E, Di Paola R, Cannavo G, Muià C, Bramanti P, Cuzzocrea S: Role of endogenous ligands for the peroxisome proliferators activated receptors alpha in the secondary damage in experimental spinal cord trauma. Exp Neurol 194:267-278, 2005.
16. Bao F, Liu D: Peroxynitrite generated in the rat spinal cord induces neuron death and neurological deficits. Neuroscience 115:839-849, 2002.
17. Cuzzocrea S, Ayroldi E, Di Paola R, Agostini M, Mazzon E, Bruscoli S, Genovese T, Ronchetti S, Caputi AP, Riccardi C: Role of glucocorticoid-induced TNF receptor family gene (GITR) in collagen-induced arthritis. FASEB J 19:1253-1265, 2005.
18. Joshi M, Fehlings MG: Development and characterization of a novel, graded model of clip compressive spinal cord injury in the mouse: part 1. Clip design, behavioral outcomes, and histopathology. J Neurotrauma 19:175-190, 2002.
19. La Rosa G, Cardali S, Genovese T, Conti A, Di Paola R, La Torre D, Cacciola F, Cuzzocrea S: Inhibition of the nuclear factor-kappaB activation with pyrrolidine dithiocarbamate attenuating inflammation and oxidative stress after experimental spinal cord trauma in rats. J Neurosurg Spine 1:311-321, 2004.
20. Schwartz MD, Moore EE, Moore FA, Shenkar R, Moine P, Haenel JB, Abraham E: Nuclear factor-kappa B is activated in alveolar macrophages from patients with the acute respiratory distress syndrome. Crit Care Med 24:1285-1292, 1996.
21. Bowie A, O'neill LA: Oxidative stress and nuclear factor-kappaB activation: a reassessment of the evidence in the light of recent discoveries. Biochem Pharmacol 59:13-23, 2000.
22. Kim GM, Xu J, Xu J, Song SK, Yan P, Ku G, Xu XM, Hsu CY: Tumor necrosis factor receptor deletion reduces nuclear factor-kappaB activation, cellular inhibitor of apoptosis protein 2 expression, and functional recovery after traumatic spinal cord injury. J Neurosci 21:6617-6625, 2001.
23. Bethea JR, Castro M, Keane RW, Lee TT, Dietrich WD, Yezierski RP: Traumatic spinal cord injury induces nuclear factor-kappaB activation. J Neurosci 18:3251-3260, 1998.
24. Di Paola R, Mazzon E, Muia C, Genovese T, Menegazzi M, Zaffini R, Suzuki H, Cuzzocrea S: Green tea polyphenol extract attenuates lung injury in experimental model of carrageenan-induced pleurisy in mice. Respir Res 6:66, 2005.
25. Streit WJ, Semple-Rowland SL, Hurley SD, Miller RC, Popovich PG, Stokes BT: Cytokine mRNA profiles in contused spinal cord and axotomized facial nucleus suggest a beneficial role for inflammation and gliosis. Exp Neurol 152:74-87, 1998.
26. Genovese T, Mazzon E, Crisafulli C, Di Paola R, Muia C, Bramanti P, Cuzzocrea S: Immunomodulatory effects of etanercept in an experimental model of spinal cord injury. J Pharmacol Exp Ther 316:1006-1016, 2006.
27. Xie QW, Kashiwabara Y, Nathan C: Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase. J Biol Chem 269:4705-4708, 1994.
28. Gruol DL, Nelson TE: Physiological and pathological roles of interleukin-6 in the central nervous system. Mol Neurobiol 15:307-339, 1997.
29. Campbell IL, Abraham CR, Masliah E, Kemper P, Inglis JD, Oldstone MB, Mucke L: Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6. Proc Natl Acad Sci U S A 90:10061-10065, 1993.
30. Tuna M, Polat S, Erman T, Ildan F, Gocer AI, Tuna N, Tamer L, Kaya M, Cetinalp E: Effect of anti-rat interleukin-6 antibody after spinal cord injury in the rat: inducible nitric oxide synthase expression, sodium and potassium-activated, magnesium-dependent adenosine-52-triphosphatase and superoxide dismutase activation, and ultrastructural changes. J Neurosurg 95:64-73, 2001.
31. Heinrich PC, Behrmann I, Haan S, Hermanns HM, Muller-Newen G, Schaper F: Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem J 374:1-20, 2003.
32. Simon AR, Rai U, Fanburg BL, Cochran BH: Activation of the JAK-STAT pathway by reactive oxygen species. Am J Physiol 275:C1640-C1652, 1998.
33. Carballo M, Conde M, El Bekay R, Martin-Nieto J, Camacho MJ, Monteseirin J, Conde J, Bedoya FJ, Sobino F: Ossidative stress triggers STAT-3 tyrosine phosphorylation and nuclear translocation in human lymphocytes. J Biol Chem 274:17580-17586, 1999.
34. Heilmann J, Winkelmann K, Sticher O: Studies on the antioxidative activity of phloroglucinol derivatives isolated from Hypericum species. Planta Med 69:202-206, 2003.
35. Ishige K, Schubert D, Sagara Y: Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms. Free Radic Biol Med 30:433-446, 2001.
36. Scott GS, Kean RB, Fabis MJ, Mikheeva T, Brimer CM, Phares TW, Spitsin SV, Hooper DC: ICAM-1 upregulation in the spinal cords of PLSJL mice with experimental allergic encephalomyelitis is dependent upon TNF-alpha production triggered by the loss of blood-brain barrier integrity. J Neuroimmunol 155:32-42, 2004.
37. Beckman JS: Oxidative damage and tyrosine nitration from peroxynitrite. Chem Res Toxicol 9:836-844, 1996.
38. Eiserich JP, Hristova M, Cross CE, Jones AD, Freeman BA, Halliwell B, Van der Vliet A: Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils. Nature 391:393-397, 1998.
39. Leist M, Volbracht C, Kuhnle S, Fava E, Ferrando-May E, Nicotera P: Caspase-mediated apoptosis in neuronal excitotoxicity triggered by nitric oxide. Mol Med 3:750-764, 1997.
40. Abe Y, Yamamoto T, Sugiyama Y, Watanabe T, Saito N, Kayama H, Kumagai T: Apoptotic cells associated with Wallerian degeneration after experimental spinal cord injury: a possible mechanism of oligodendroglial death. J Neurotrauma 16:945-952, 1999.