CD8 T cells require Bcl-3 for maximal gamma interferon production upon secondary exposure to antigen

Infection and Immunity

Volumn 74, Issue 7, 2006, Pages 4180-4189

  Chilton, Paula M ^a   Mitchell, Thomas C ^a,b  

^a UNIVERSITY OF LOUISVILLE   (United States)

^b University of Louisville School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; GAMMA INTERFERON; I KAPPA B; I KAPPA B ALPHA; I KAPPA B BETA; I KAPPA B EPSILON; LIPOPOLYSACCHARIDE; PROTEIN BCL 3; STAPHYLOCOCCUS ENTEROTOXIN B; UNCLASSIFIED DRUG;

ARTICLE; CD8+ T LYMPHOCYTE; CELL SURVIVAL; IN VITRO STUDY; INTERFERON PRODUCTION; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TRANSCRIPTION REGULATION;

ANIMALS; ANTIGENS; CD8-POSITIVE T-LYMPHOCYTES; CELL SURVIVAL; ENTEROTOXINS; INTERFERON TYPE II; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PROTO-ONCOGENE PROTEINS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 33745608224     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.01749-05     Document Type: Article

References (39)

1. Aune, T. M., L. A. Penix, M. R. Rincon, and R. A. Flavell. 1997. Differential transcription directed by discrete gamma interferon promoter elements in naive and memory (effector) CD4 T cells and CD8 T cells. Mol. Cell. Biol. 17:199-208.
2. H cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes. Nat. Immunol. 3:643-651.
3. Bloomfield, C. D., D. C. Arthur, G. Frizzera, E. G. Levine, B. A. Peterson, and K. J. Gajl-Peczalska. 1983. Nonrandom chromosome abnormalities in lymphoma. Cancer Res. 43:2975-2984.
4. Carragher, D., R. Johal, A. Button, A. White, A. Eliopoulos, E. Jenkinson, G. Andersen, and J. Caamano. 2004. A stroma-derived defect in NF-kappaB2-/-mice causes impaired lymph node development and lymphocyte recruitment. J. Immunol. 173:2271-2279.
5. + T cells. J. Exp. Med. 189:1355-1360.
6. Reference deleted.
7. Corn, R. A., C. Hunter, H. C. Liou, U. Siebenlist, and M. R. Boothby. 2005. Opposing roles for RelB and Bcl-3 in regulation of T-Box expressed in T Cells, GATA-3, and Th effector differentiation. J. Immunol. 175:2102-2110.
8. Fenton, R. G., P. Marrack, J. W. Kappler, O. Kanagawa, and J. G. Seidman. 1988. Isotypic exclusion of gamma delta T cell receptors in transgenic mice bearing a rearranged beta-chain gene. Science 241:1089-1092.
9. Franzoso, G., L. Carlson, T. Scharton-Kersten, E. W. Shores, S. Epstein, A. Grinberg, T. Tran, E. Shacter, A. Leonardi, M. Anver, P. Love, A. Sher, and U. Siebenlist. 1997. Critical roles for the Bcl-3 oncoprotein in T cell-mediated immunity, splenic microarchitecture, and germinal center reactions. Immunity 6:479-490.
10. Gomez-Angelats, M., C. D. Bortner, and J. A. Cidlowski. 2000. Cell volume regulation in immune cell apoptosis. Cell Tissue Res. 301:33-42.
11. Goudeau, B., F. Huetz, S. Samson, J. P. Di Santo, A. Cumano, A. Beg, A. Israel, and S. Memet. 2003. IkappaBalpha/IkappaBepsilon deficiency reveals that a critical NF-kappaB dosage is required for lymphocyte survival. Proc. Natl. Acad. Sci. USA 100:15800-15805.
12. + T cells. J. Biol. Chem. 279:8460-8468.
13. Hildeman, D. A., T. Mitchell, B. Aronow, S. Wojciechowski, J. Kappler, and P. Marrack. 2003. Control of Bcl-2 expression by reactive oxygen species. Proc. Natl. Acad. Sci. USA 100:15035-15040.
14. Jamaluddin, M., S. Choudhary, S. Wang, A. Casola, R. Huda, R. P. Garofalo, S. Ray, and A. R. Brasier. 2005. Respiratory syncytial virus-inducible BCL-3 expression antagonizes the STAT/IRF and NF-κB signaling pathways by inducing histone deacetylase 1 recruitment to the interleukin-8 promoter. J. Virol. 79:15302-15313.
15. Kearney, E. R., K. A. Pape, D. Y. Loh, and M. K. Jenkins. 1994. Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo. Immunity 1:327-339.
16. Khoruts, A., A. Mondino, K. A. Pape, S. L. Reiner, and M. K. Jenkins. 1998. A natural immunological adjuvant enhances T cell clonal expansion through a CD28-dependent, interleukin (IL)-2-independent mechanism. J. Exp. Med. 187:225-236.
17. + T cell lineage commitment. Nat. Immunol. 6:793-799.
18. Maxwell, J. R., C. Ruby, N. I. Kerkvliet, and A. T. Vella. 2002. Contrasting the roles of costimulation and the natural adjuvant lipopolysaccharide during the induction of T cell immunity. J. Immunol. 168:4372-4381.
19. McKeithan, T. W., J. D. Rowley, T. B. Shows, and M. O. Diaz. 1987. Cloning of the chromosome translocation breakpoint junction of the t(14;19) in chronic lymphocytic leukemia. Proc. Natl. Acad. Sci. USA 84:9257-9260.
20. McKeithan, T. W., G. S. Takimoto, H. Ohno, V. S. Bjorling, R. Morgan, B. K. Hecht, I. Dube, A. A. Sandberg, and J. D. Rowley. 1997. BCL3 rearrangements and t(14;19) in chronic lymphocytic leukemia and other B-cell malignancies: a molecular and cytogenetic study. Genes Chromosomes Cancer 20:64-72.
21. Memet, S., D. Laouini, J. C. Epinat, S. T. Whiteside, B. Goudeau, D. Philpott, S. Kayal, P. J. Sansonetti, P. Berche, J. Kanellopoulos, and A. Israel. 1999. IkappaBepsilon-deficient mice: reduction of one T cell precursor subspecies and enhanced Ig isotype switching and cytokine synthesis. J. Immunol. 163:5994-6005.
22. Mitchell, T. C., D. Hildeman, R. M. Kedl, T. K. league, B. C. Schaefer, J. White, Y. Zhu, J. Kappler, and P. Marrack. 2001. Immunological adjuvants promote activated T cell survival via induction of Bcl-3. Nat. Immunol. 2:397-402.
23. Mitchell, T. C., T. K. Teague, D. A. Hildeman, J. Bender, W. A. Rees, R. M. Kedl, B. Swanson, J. W. Kappler, and P. Marrack. 2002. Stronger correlation of bcl-3 than bcl-2, bcl-xL, costimulation, or antioxidants with adjuvant-induced T cell survival. Ann. N. Y. Acad. Sci. 975:114-131.
24. Mitchell, T. C., B. S. Thompson, J. O. Trent, and C. R. Casella. 2002. A short domain within Bcl-3 is responsible for its lymphocyte survival activity. Ann. N. Y. Acad. Sci. 975:132-147.
25. Mittal, A., S. Papa, G. Franzoso, and R. Sen. 2006. NF-kappaB-dependent regulation of the timing of activation-induced cell death of T lymphocytes. J. Immunol. 176:2183-2189.
26. Ong, S. T., M. L. Hackbarth, L. C. Degenstein, D. A. Baunoch, J. Anastasi, and T. W. McKeithan. 1998. Lymphadenopathy, splenomegaly, and altered immunoglobulin production in BCL3 transgenic mice. Oncogene 16:2333-2343.
27. + T cell function by the transcription factor Eomesodermin. Science 302:1041-1043.
28. Riemann, M., R. Endres, S. Liptay, K. Pfeffer, and R. M. Schmid. 2005. The IkappaB protein Bcl-3 negatively regulates transcription of the IL-10 gene in macrophages. J. Immunol. 175:3560-3568.
29. Rocha, S., A. M. Martin, D. W. Meek, and N. D. Perkins. 2003. p53 represses cyclin D1 transcription through down regulation of Bcl-3 and inducing increased association of the p52 NF-kappaB subunit with histone deacetylase 1. Mol. Cell Biol. 23:4713-4727.
30. Salem, M. L., A. N. Kadima, D. J. Cole, and W. E. Gillanders. 2005. Defining the antigen-specific T-cell response to vaccination and poly(I:C)/TLR3 signaling: evidence of enhanced primary and memory CD8 T-cell responses and antitumor immunity. J. Immunother. 28:220-228.
31. Schwarz, E. M., P. Krimpenfort, A. Berns, and I. M. Verma. 1997. Immunological defects in mice with a targeted disruption in Bcl-3. Genes Dev. 11:187-197.
32. Sengupta, S., P. M. Chilton, and T. C. Mitchell. 2005. Adjuvant-induced survival signaling in clonally expanded T cells is associated with transient increases in pAKT levels and sustained uptake of glucose. Immunobiology 210:647-659.
33. Thompson, B. S., and T. C. Mitchell. 2004. Measurement of daughter cell accumulation during lymphocyte proliferation in vivo. J Immunol. Methods 295:79-87.
34. Valenzuela, J. O., C. D. Hammerbeck, and M. F. Mescher. 2005. Cutting edge: Bcl-3 up-regulation by signal 3 cytokine (IL-12) prolongs survival of antigen-activated CD8 T cells. J. Immunol. 174:600-604.
35. Vella, A. T., J. E. McCormack, P. S. Linsley, J. W. Kappler, and P. Marrack. 1995. Lipopolysaccharide interferes with the induction of peripheral T cell death. Immunity 2:261-270.
36. Vella, A. T., T. Mitchell, B. Groth, P. S. Linsley, J. M. Green, C. B. Thompson, J. W. Kappler, and P. Marrack. 1997. CD28 engagement and proinflammatory cytokines contribute to T cell expansion and long-term survival in vivo. J. Immunol. 158:4714-4720.
37. Wessells, J., M. Baer, H. A. Young, E. Claudio, K. Brown, U. Siebenlist, and P. F. Johnson. 2004. BCL-3 and NF-kappaB p50 attenuate lipopolysaccharide- induced inflammatory responses in macrophages. J. Biol. Chem. 279:49995-50003.
38. Whiteside, S. T., J. C. Epinat, N. R. Rice, and A. Israel. 1997. I kappa B epsilon, a novel member of the I kappa B family, controls RelA and c-Rel NF-kappa B activity. EMBO J. 16:1413-1426.
39. Zhou, W., S. Chang, and T. M. Aune. 2004. Long-range histone acetylation of the Ifng gene is an essential feature of T cell differentiation. Proc. Natl. Acad. Sci. USA 101:2440-2445.