Comparative effects of hypoxia on normal and immortalized human diploid fibroblasts

Anticancer Research

Volumn 26, Issue 3 A, 2006, Pages 2165-2168

  Poulios, Efthymios ^a,b   Trougakos, Ioannis P ^a   Gonos, Efstathios S ^a  

^a INSTITUTE OF BIOLOGY   (Greece)

^b UNIVERSITY OF THESSALY   (Greece)

Author keywords

Bcl 2; Clusterin apolipoprotein J; Human fibroblasts; Hypoxia; Immortalization; Replicative senescence; SV40 T antigen

Indexed keywords

CLUSTERIN; COBALT CHLORIDE; ERYTHROPOIETIN; HYPOXIA INDUCIBLE FACTOR 1; PROTEIN BCL 2; VASCULOTROPIN; VIRUS T ANTIGEN;

ARTICLE; CELL IMMORTALIZATION; CELL TYPE; CONTROLLED STUDY; DIPLOIDY; FIBROBLAST; GENE CONTROL; GENE REPLICATION; GENE TARGETING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HYPOXIA; OXYGEN CONCENTRATION; OXYGEN TENSION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; SENESCENCE; SIMIAN VIRUS 40; SURVIVAL;

CELL AGING; CELL HYPOXIA; COBALT; DIPLOIDY; FIBROBLASTS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; OXYGEN;

EID: 33745603984     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Semenza GL: HIF-1 and human disease: one highly involved factor. Genes Dev 14: 1983-1991, 2000.
2. Chun YS, Kim MS and Park JW: Oxygen-dependent and -independent regulation of HIF-1 alpha. J Korean Med Sci 17: 581-588, 2002.
3. Lee JW, Bae SH, Jeong JW, Kim SH and Kim KW: Hypoxia-inducible factor (HIF-1)alpha: its protein stability and biological functions. Exp Mol Med 36: 1-12, 2004.
4. 2-regulated gene expression. FASEB J 16: 1151-1162, 2002.
5. Kim H, Lee DK, Choi JW, Kim JS, Park SC and Youn HD: Analysis of the effect of aging on the response to hypoxia by cDNA microarray. Mech Ageing Dev 124: 941-949, 2003.
6. Allen G and Balin AK: Effects of oxygen on the antioxidant responses of normal and transformed cells. Exp Cell Res 289: 307-316, 2003.
7. Lerman OZ, Galiano RD, Armour M, Levine JP and Gurtner GC: Cellular dysfunction in the diabetic fibroblast: impairment in migration, vascular endothelial growth factor production, and response to hypoxia. Am J Pathol 162: 303-312, 2003.
8. Petropoulou C, Trougakos IP, Kolettas E, Toussaint O and Gonos ES: Clusterin/apolipoprotein J is a novel biomarker of cellular senescence that does not affect the proliferative capacity of human diploid fibroblasts. FEBS Lett 509: 287-297, 2001.
9. Bunn HF, Gu J, Huang LE, Park JW and Zhu H: Erythropoietin: a model system for studying oxygen-dependent gene regulation. J Exp Biol 201: 1197-1201, 1998.
10. Levy AP, Levy NS, Wegner S and Goldberg MA: Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia. J Biol Chem 270: 13333-13340, 1995.
11. Trougakos IP and Gonos ES: Clusterin/apolipoprotein J in human aging and cancer. Int J Biochem Cell Biol 34: 1430-1448, 2002.
12. May PC, Robison P, Fuson K, Smalstig B, Stephenson D and Clemens JA: Sulfated glycoprotein-2 expression increases in rodent brain after transient global ischemia. Brain Res Mol Brain Res 15: 33-39, 1992.
13. Walton M, Young D, Sirimanne E, Dodd J, Christie D, Williams C, Gluckman P and Dragunow M: Induction of clusterin in the immature brain following a hypoxic-ischemic injury. Brain Res Mol Brain Res 39: 137-152, 1996.
14. Han BH, DeMattos RB, Dugan LL, Kim-Han JS, Brendza RP, Fryer JD, Kierson M, Cirrito J, Quick K, Harmony JA, Aronow BJ and Holtzman DM: Clusterin contributes to caspase-3-independent brain injury following neonatal hypoxia-ischemia. Nat Med 7: 338-343, 2001.
15. Wehlri P, Charnay Y, Vallet P, Zhu G, Harmony J, Aronow B, Tschopp J, Bouras C, Viard-Leveugle I, French LE and Giannakopoulos P: Inhibition of post-ischemic brain injury by clusterin overexpression. Nat Med 7: 977-979, 2001.
16. Dong Z and Wang J: Hypoxia selection of death-resistant cells. A role for Bcl-X(L). J Biol Chem 279: 9215-9221, 2004.
17. Baek JH, Jang JE, Kang CM, Chung HY, Kim ND and Kim KW: Hypoxia-induced VEGF enhances tumor survivability via suppression of serum deprivation-induced apoptosis. Oncogene 19: 4621-4631, 2000.
18. 2 protect HepG2 cells against serum deprivation- and t-BHP-induced apoptosis: a possible antiapoptotic role for HIF-1. Exp Cell Res 295: 340-349, 2004.
19. Frenkel-Denkberg G, Gershon D and Levy AP: The function of hypoxia-inducible factor 1 (HIF-1) is impaired in senescent mice. FEBS Lett 462: 341-344, 1999.
20. Ali SH and DeCaprio JA: Cellular transformation by SV40 large T antigen: interaction with host proteins. Semin Cancer Biol 11: 15-23, 2001.
21. Chen D, Li M, Luo J and Gu W: Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function. J Biol Chem 278: 13595-13598, 2003.
22. Schmid T, Zhou J and Brune B: HIF-1 and p53: communication of transcription factors under hypoxia. J Cell Mol Med 8: 423-431, 2004.