Synthesis of piperazinephen-1-ylethylamines as potent and selective antagonists of the human melanocortin-4 receptor

Letters in Drug Design and Discovery

Volumn 3, Issue 5, 2006, Pages 311-315

  Tucci, Fabio C ^a   Tran, Joe A ^a   Jiang, Wanlong ^a   Pontillo, Joseph ^a   Marinkovic, Dragan ^a   White, Nicole S ^a   Arellano, Melissa ^a   Fleck, Beth A ^a   Wen, Jenny ^a   Saunders, John ^a   Foster, Alan C ^a   Chen, Chen ^a  

^a NEUROCRINE BIOSCIENCES INC   (United States)

Author keywords

Antagonist; Melanocortin; Piperazinephenylamine; Synthesis

Indexed keywords

HORMONE RECEPTOR BLOCKING AGENT; LEAD; MELANOCORTIN 4 RECEPTOR; PIPERAZINEPHEN 1 YLETHYLAMINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CHIRALITY; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; LIPOPHILICITY; NONHUMAN; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION;

EID: 33745601369     PISSN: 15701808     EISSN: None     Source Type: Journal    
DOI: 10.2174/157018006777574249     Document Type: Article

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