Structure-activity studies on the protection of Trimetazidine derivatives modified with nitroxides and their precursors from myocardial ischemia-reperfusion injury

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 16, 2006, Pages 5510-5516

  Kálai, Tamás ^a   Khan, Mahmood ^b   Balog, Mária ^a   Kutala, Vijay Kumar ^b   Kuppusamy, Periannan ^b   Hideg, Kálmán ^a  

^a UNIVERSITY OF PÉCS   (Hungary)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

Langendorff perfused heart; Nitroxides; ROS scavenging activity; Trimetazidine

Indexed keywords

1 HYDROXY 2,2,5,5 TETRAMETHYL 2,5 DIHYDRO 1H PYRROL 3 YL[4 (2,3,4 TRIMETHOXYBENZYL)PIPERAZIN 1 YL]METHANONE; 1 HYDROXY 2,2,5,5 TETRAMETHYL 3 [4 (2,3,4 TRIMETHOXYBENZYL)PIPERAZIN 1 YLMETHYL] 2,5 DIHYDRO 1H PYRROLE; 1 HYDROXY 2,2,6,6 TETRAMETHYL 4 [4 (2,3,4 TRIMETHOXYBENZYL)PIPERAZIN 1 YLMETHYL] 1,2,3,6 TERAHYDROPYRIDINE; 1,2,2,5,5 PENTAMETHYL 3 [4 (2,3,4 TRIMETHOXYBENZYL)PIPERAZIN 1 YLMETHYL] 2,5 DIHYDRO 1H PYRROLE; 2,2,5,5 TETRAMETHYL 2,5 DIHYDRO 1H PYRROL 3 YL[4 (2,3,4 TRIMETHOXYBENZYL)PIPERAZIN 1 YL]METHANONE; 2,2,5,5 TETRAMETHYL 2,5 DIHYDRO 1H PYRROLE; 2,2,5,5 TETRAMETHYL 3 [4 (2,3,4 TRIMETHOXYBENZYL)PIPERAZIN 1 YLMETHYL] 2,5 DIHYDRO 1H PYRROLE; 2,2,6,6 TETRAMETHYL 4 [4 (2,3,4 TRIMETHOXYBENZYL)PIPERAZIN 1 YLMETHYL] 1,2,3,6 TETRAHYDROPYRIDINE; 4 PHENYL 2,2,5,5 TETRAMETHYL 2,5 DIHYDRO 1H PYRROLE; 4 PHENYL 2,2,5,5 TETRAMETHYL 3 [4 (2,3,4 TRIMETHOXYBENZYL)PIPERAZIN 1 YLMETHYL] 2,5 DIHYDRO 1H PYRROLE; AMINE; ANTIOXIDANT; CORONARY VASODILATING AGENT; HO 2921; HO 2922; HO 2943; HO 3594; HO 3595; HO 3615; HO 3630; HYDROXYLAMINE; NITROXIDE DERIVATIVE; PYRROLINE DERIVATIVE; REACTIVE OXYGEN METABOLITE; TRIMETAZIDINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; HEART DISEASE; HEART MUSCLE ISCHEMIA; IN VITRO STUDY; ISOLATED HEART; NONHUMAN; PROTECTION; RAT; REPERFUSION INJURY; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIOXIDANTS; MYOCARDIAL REPERFUSION INJURY; NITROGEN OXIDES; PIPERAZINES; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; STRUCTURE-ACTIVITY RELATIONSHIP; TRIMETAZIDINE; VASODILATOR AGENTS;

EID: 33745600577     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.04.040     Document Type: Article

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31. Will be published elsewhere.