A pyrroline derivative of mexiletine offers marked protection against ischemia/reperfusion-induced myocardial contractile dysfunction

Journal of Pharmacology and Experimental Therapeutics

Volumn 295, Issue 2, 2000, Pages 563-571

  Li, H ^a   Xu, K Y ^a   Zhou, L ^a   Kalai, T ^a   Zweier, J L ^a   Hideg, K ^a   Kuppusamy, P ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2,6 DIMETHYLPHENOXY) [2 N (2,5 DIHYDRO 3 METHYL 2,2,5,5 TETRAMETHYL 1H PYRROL)]AMINOPROPANE; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); HO 2434; MEXILETINE; PYRROLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; DRUG BINDING SITE; DRUG EFFICACY; DRUG MECHANISM; ENZYME INHIBITION; FEMALE; HEART FAILURE; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE CONTRACTILITY; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMAL; ANTI-ARRHYTHMIA AGENTS; ANTIOXIDANTS; BINDING, COMPETITIVE; COMPARATIVE STUDY; CORONARY CIRCULATION; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HYDROXYL RADICAL; MEXILETINE; MYOCARDIAL CONTRACTION; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; NA(+)-K(+)-EXCHANGING ATPASE; OUABAIN; OXIDATION-REDUCTION; PYRROLES; RATS; RATS, SPRAGUE-DAWLEY; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; VENTRICULAR DYSFUNCTION, LEFT; VENTRICULAR PRESSURE;

EID: 0033779864     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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