Advances in iron overload therapies. Prospects for effective use of deferiprone (L1), deferoxamine, the new experimental chelators ICL670, GT56-252, L1NAll and their combinations

Current Medicinal Chemistry

Volumn 12, Issue 23, 2005, Pages 2663-2681

  Kontoghiorghes, George J ^a   Eracleous, Eleni ^a   Economides, Charalambos ^a   Kolnagou, Annita ^a  

^a Postgraduate Research Institute of Science Technology Environment and Medicine Limassol   (Cyprus)

Author keywords

Deferiprone; Deferoxamine; GT56 252; ICL670; Idiopathic haemochromatosis; Iron chelators; Iron overload; L1NAll; Thalassaemia

Indexed keywords

1 ALLYL 2 METHYLHYDROXYPYRID 4 ONE; 4,5 DIHYDRO 2 (2,4 DIHYDROXYPHENYL) 4 METHYLTHIAZOLE 4 CARBOXYLIC ACID; CHELATING AGENT; CLOZAPINE; DEFERASIROX; DEFERIPRONE; DEFERITRIN; DEFEROXAMINE; HYDRALAZINE; IRON CHELATING AGENT; PENICILLAMINE; POLYMER; UNCLASSIFIED DRUG;

ABDOMINAL PAIN; AGRANULOCYTOSIS; ARTHRALGIA; BONE DISEASE; CLINICAL TRIAL; DIARRHEA; DRUG BLOOD LEVEL; DRUG COST; DRUG DOSE REGIMEN; DRUG EFFICACY; DRUG ELIMINATION; DRUG MECHANISM; DRUG METABOLISM; DRUG STRUCTURE; DRUG USE; EYE DISEASE; GASTROINTESTINAL SYMPTOM; HEARING DISORDER; HEART INJURY; HEAVY METAL REMOVAL; HEMOCHROMATOSIS; HUMAN; INJECTION SITE REACTION; IRON ABSORPTION; IRON BALANCE; IRON OVERLOAD; IRON STORAGE; MONOTHERAPY; MUCORMYCOSIS; MYALGIA; NAUSEA; NEPHROTOXICITY; NEUTROPENIA; NONHUMAN; PANCYTOPENIA; PHLEBOTOMY; RASH; REFRACTORY ANEMIA; REVIEW; STRUCTURE ANALYSIS; THALASSEMIA; TISSUE DISTRIBUTION; VOMITING; YERSINIOSIS;

BENZOIC ACIDS; CARBOXYLIC ACIDS; DEFEROXAMINE; DRUG THERAPY, COMBINATION; HEMOCHROMATOSIS; HUMANS; IRON CHELATING AGENTS; IRON OVERLOAD; PYRIDONES; SIDEROPHORES; THALASSEMIA; THIAZOLES; TRIAZOLES;

EID: 27744544284     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986705774463003     Document Type: Review

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