Genetics of platelet receptor single-nucleotide polymorphisms: Clinical implications in thrombosis

Annals of Medicine

Volumn 32, Issue SUPPL. 1, 2000, Pages 10-14

  Beer, J H ^a   Pederiva, S ^a   Pontiggia, L ^a  

^a Kantonsspital Baden   (Switzerland)

Author keywords

Myocardial infarction; Platelet; Platelet membrane glycoproteins; Single nucleotide polymorphism; Stroke; Thrombosis

Indexed keywords

ACTIN POLYMERIZATION; CARDIOVASCULAR RISK; CIGARETTE SMOKING; CONFERENCE PAPER; GENETIC ANALYSIS; HEART INFARCTION; HUMAN; PRIORITY JOURNAL; PROTEINURIA; SINGLE NUCLEOTIDE POLYMORPHISM; STROKE; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOSIS;

ANGINA PECTORIS; CEREBROVASCULAR ACCIDENT; HUMANS; INTEGRINS; MYOCARDIAL INFARCTION; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; THROMBOSIS;

EID: 0034496491     PISSN: 07853890     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (30)

1. Increased binding of fibrinogen to glycoprotein IIIa proline33 (HPA-1b, PlA2, Zwb) positive platelets in patients with cardiovascular disease
2. The PlA2 alloantigen does not alter the affinity of GP IIb/IIIa for fibrinogen or RGD containing peptides
3. Platelet glycoprotein IIIa polymorphism HPA1b (PlA2): No association with platelet fibrinogen binding
4. A polymorphisms display different sensitivities to agonists
5. Increased platelet aggregability associated with platelet GPIIIa PlA2 polymorphism: The Framingham Offspring Study
6. Interdonor variability of platelet response to thrombin receptor activation: Influence of PlA2 polymorphism
7. 3 enhances outside-in signaling and adhesive functions
8. 33 and con
9. A polymorphism of a platelet glycoprotein receptor as an inherited risk factor for coronary thrombosis
10. A polymorphism of glycoprotein IIb/IIIa and the fibrinogen Bbeta 448 polymorphism with myocardial infarction and extent of coronary artery disease
11. A2 gene polymorphism to coronary artery disease but not to nonfatal myocardial infarction in low risk patients
12. A2) is an inherited risk factor for premature myocardial infarction in coronary artery disease
13. A polymorphism associates with progression of coronary artery disease and with myocardial infarction in an autopsy series of middleaged men who died suddenly
14. A polymorphism in the progression of abdominal aortic atherosclerosis
15. Platelet glycoprotein IIIa polymorphisms and risk of coronary stent thrombosis
16. A2 polymorphism in siblings of patients with premature coronary heart disease
17. A1/A2 polymorphism of platelet glycoprotein IIIa and risks of myocardial infarction, stroke, and venous thrombosis
18. A2) of the Glycoprotein IIIa (GPIIIa) receptor is not related to myocardial infarction in the ECTIM Study
19. Pla1/a2 polymorphism of glycoprotein IIIa and risk of coronary artery disease and restenosis following coronary angioplasty
20. Platelet Pl(A2) allele and incidence of coronary heart disease: Results from the atherosclerosis risk in communities (ARIC) study
21. 1 activity on human platelets
22. Hereditary variation in platelet integrin alpha 2 beta 1 density is associated with two silent polymorphisms in the alpha 2 gene coding sequence
23. Platelet surface collagen receptor polymorphisms: Variable receptor expression and thrombotic/hemorrhagic risk
24. Human blood platelets showing no response to collagen fail to express surface glycoprotein Ia
25. Deficiency of antibody 6F1 binding to the platelets of a patient with an isolated defect in platelet-collagen interaction
26. Lack of platelet response to collagen associated with an autoantibody against glycoprotein Ia: A novel cause of acquired platelet dysfunction
27. Low platelet alpha2beta1 levels in type I von Willebrand disease correlate with impaired platelet function in a high shear stress system
28. Association of two silent polymorphisms of platelet glycoprotein Ia/IIa receptor with risk of myocardial infarction: A case-control study
29. The alpha2 gene coding sequence T807/A873 of the platelet collagen receptor integrin alpha2beta1 might be a genetic risk factor for the development of stroke in younger patients
30. Homozygosity for 807 T polymorphism in alpha (2) subunit of platelet alpha (2) beta (1) is associated with increased risk of cardiovascular mortality in high-risk women