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Volumn 42, Issue 5, 2006, Pages 299-312

Atrasentan: A rationally designed targeted therapy for cancer

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; ATRASENTAN; BIOLOGICAL MARKER; BOSENTAN; CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; ENDOTHELIN; ENDOTHELIN 1; ENDOTHELIN 2; ENDOTHELIN 3; ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; ENDOTHELIN RECEPTOR; FEXOFENADINE; KETOCONAZOLE; N (2,6 DIMETHYLPIPERIDINOCARBONYL) 4 METHYLLEUCYL DEXTRO (1 METHOXYCARBONYLTRYPTOPHANYL) DEXTRO NORLEUCINE; ORGANIC ANION TRANSPORTER; PACLITAXEL; PHENYTOIN; RIFAMPICIN; WARFARIN; WORTMANNIN;

EID: 33745548413     PISSN: 16993993     EISSN: 16994019     Source Type: Journal    
DOI: 10.1358/dot.2006.42.5.973590     Document Type: Review
Times cited : (12)

References (66)
  • 1
    • 0037426058 scopus 로고    scopus 로고
    • Prostate cancer epidemiology
    • Gronberg, H. Prostate cancer epidemiology. Lancet 2003, 361: 859-64.
    • (2003) Lancet , vol.361 , pp. 859-864
    • Gronberg, H.1
  • 2
    • 0028870560 scopus 로고
    • Hormone refractory disease
    • Mahler, C., Denis, L.J. Hormone refractory disease. Semin Surg Oncol 1995, 11: 77-83.
    • (1995) Semin Surg Oncol , vol.11 , pp. 77-83
    • Mahler, C.1    Denis, L.J.2
  • 3
    • 4744366279 scopus 로고    scopus 로고
    • Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer
    • Tannock, I.F., de Wit, R., Berry, W.R. et al. Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer. N Engl J Med 2004, 351: 1502-12.
    • (2004) N Engl J Med , vol.351 , pp. 1502-1512
    • Tannock, I.F.1    De Wit, R.2    Berry, W.R.3
  • 4
    • 4744337716 scopus 로고    scopus 로고
    • Docetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancer
    • Petrylak, D.P., Tangen, C.M., Hussain, M.H. et al. Docetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancer. N Engl J Med 2004, 351: 1513-20.
    • (2004) N Engl J Med , vol.351 , pp. 1513-1520
    • Petrylak, D.P.1    Tangen, C.M.2    Hussain, M.H.3
  • 5
    • 0036411742 scopus 로고    scopus 로고
    • Clinical trial design for target-based therapy
    • Fox, E., Curt, G.A., Balis, F.M. Clinical trial design for target-based therapy. Oncologist 2002, 7: 401-9.
    • (2002) Oncologist , vol.7 , pp. 401-409
    • Fox, E.1    Curt, G.A.2    Balis, F.M.3
  • 6
    • 0028154980 scopus 로고
    • Clinical review 53: The endocrinology of vasoactive peptides: Synthesis to function
    • Rubin, S.A., Levin, E.R. Clinical review 53: The endocrinology of vasoactive peptides: Synthesis to function. J Clin Endocrinol Metab 1994, 78: 6-10.
    • (1994) J Clin Endocrinol Metab , vol.78 , pp. 6-10
    • Rubin, S.A.1    Levin, E.R.2
  • 8
    • 0029116310 scopus 로고
    • Endothelins
    • Levin, E.R. Endothelins. N Engl J Med 1995, 333: 356-63.
    • (1995) N Engl J Med , vol.333 , pp. 356-363
    • Levin, E.R.1
  • 9
    • 0030444643 scopus 로고    scopus 로고
    • The endothelin system and its potential as a therapeutic target in cardiovascular disease
    • Gray, G.A., Webb, D.J. The endothelin system and its potential as a therapeutic target in cardiovascular disease. Pharmacol Ther 1996, 72: 109-48.
    • (1996) Pharmacol Ther , vol.72 , pp. 109-148
    • Gray, G.A.1    Webb, D.J.2
  • 10
    • 4344625871 scopus 로고    scopus 로고
    • Endothelin receptors as novel targets in tumor therapy
    • Bagnato, A., Natali, P.G. Endothelin receptors as novel targets in tumor therapy. J Transl Med 2004, 2: 16.
    • (2004) J Transl Med , vol.2 , pp. 16
    • Bagnato, A.1    Natali, P.G.2
  • 11
    • 0033761991 scopus 로고    scopus 로고
    • Protein kinase C delta but not PKC epsilon activity is involved in contractile potentiation by endothelin-1 in the porcine coronary artery
    • Obara, K., Koide, M., Ishikawa, T., Tanabe, Y., Nakayama, K. Protein kinase C delta but not PKC epsilon activity is involved in contractile potentiation by endothelin-1 in the porcine coronary artery. J Cardiovasc Pharmacol 2000, 36: S120-S121.
    • (2000) J Cardiovasc Pharmacol , vol.36
    • Obara, K.1    Koide, M.2    Ishikawa, T.3    Tanabe, Y.4    Nakayama, K.5
  • 12
    • 0030044360 scopus 로고    scopus 로고
    • Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors
    • Daub, H., Weiss, F.U., Wallasch, C., Ullrich, A. Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors. Nature 1996, 379: 557-60.
    • (1996) Nature , vol.379 , pp. 557-560
    • Daub, H.1    Weiss, F.U.2    Wallasch, C.3    Ullrich, A.4
  • 13
    • 0032932862 scopus 로고    scopus 로고
    • Endothelin-1 modulates insulin signaling through phosphatidylinositol 3-kinase pathway in vascular smooth muscle cells
    • Jiang, Z.Y., Zhou, Q.L., Chatterjee, A. et al. Endothelin-1 modulates insulin signaling through phosphatidylinositol 3-kinase pathway in vascular smooth muscle cells. Diabetes 1999, 48: 1120-30.
    • (1999) Diabetes , vol.48 , pp. 1120-1130
    • Jiang, Z.Y.1    Zhou, Q.L.2    Chatterjee, A.3
  • 15
    • 0034665584 scopus 로고    scopus 로고
    • Transactivation of the epidermal growth factor receptor in endothelin-1-induced mitogenic signaling in human ovarian carcinoma cells
    • Vacca, F., Bagnato, A., Catt, K.J., Tecce, R. Transactivation of the epidermal growth factor receptor in endothelin-1-induced mitogenic signaling in human ovarian carcinoma cells. Cancer Res 2000, 60: 5310-7.
    • (2000) Cancer Res , vol.60 , pp. 5310-5317
    • Vacca, F.1    Bagnato, A.2    Catt, K.J.3    Tecce, R.4
  • 17
    • 0036884694 scopus 로고    scopus 로고
    • New therapeutics that antagonize endothelin: Promises and frustrations
    • Remuzzi, G., Perico, N., Benigni, A. New therapeutics that antagonize endothelin: Promises and frustrations. Nat Rev Drug Discov 2002, 1: 986-1001.
    • (2002) Nat Rev Drug Discov , vol.1 , pp. 986-1001
    • Remuzzi, G.1    Perico, N.2    Benigni, A.3
  • 20
    • 29144495415 scopus 로고    scopus 로고
    • Endothelin-1 promotes epithelial-to-mesenchymal transition in human ovarian cancer cells
    • Rosano, L., Spinella, F., Di Castro, V et al. Endothelin-1 promotes epithelial-to-mesenchymal transition in human ovarian cancer cells. Cancer Res 2005, 65: 11649-57.
    • (2005) Cancer Res , vol.65 , pp. 11649-11657
    • Rosano, L.1    Spinella, F.2    Di Castro, V.3
  • 21
    • 0029085123 scopus 로고
    • Identification of endothelin-1 in the pathophysiology of metastatic adenocarcinoma of the prostate
    • Nelson, J.B., Hedican, S.P., George, D.J. et al. Identification of endothelin-1 in the pathophysiology of metastatic adenocarcinoma of the prostate. Nat Med 1995, 1: 944-9.
    • (1995) Nat Med , vol.1 , pp. 944-949
    • Nelson, J.B.1    Hedican, S.P.2    George, D.J.3
  • 22
    • 0030047858 scopus 로고    scopus 로고
    • Endothelin-1 production and decreased endothelin B receptor expression in advanced prostate cancer
    • Nelson, J.B., Chan-Tack, K., Hedican, S.P. et al. Endothelin-1 production and decreased endothelin B receptor expression in advanced prostate cancer. Cancer Res 1996, 56: 663-8.
    • (1996) Cancer Res , vol.56 , pp. 663-668
    • Nelson, J.B.1    Chan-Tack, K.2    Hedican, S.P.3
  • 23
    • 0031889217 scopus 로고    scopus 로고
    • Neutral endopeptidase 24.11 loss in metastatic human prostate cancer contributes to androgen-independent progression
    • Papandreou, C.N., Usmani, B., Geng, Y. et al. Neutral endopeptidase 24.11 loss in metastatic human prostate cancer contributes to androgen-independent progression. Nat Med 1998, 4: 50-7.
    • (1998) Nat Med , vol.4 , pp. 50-57
    • Papandreou, C.N.1    Usmani, B.2    Geng, Y.3
  • 24
    • 0031026396 scopus 로고    scopus 로고
    • Methylation of the 5′ CpG island of the endothelin B receptor gene is common in human prostate cancer
    • Nelson, J.B., Lee, W.H., Nguyen, S.H. et al. Methylation of the 5′ CpG island of the endothelin B receptor gene is common in human prostate cancer. Cancer Res 1997, 57: 35-7.
    • (1997) Cancer Res , vol.57 , pp. 35-37
    • Nelson, J.B.1    Lee, W.H.2    Nguyen, S.H.3
  • 25
    • 0036671726 scopus 로고    scopus 로고
    • Differential expression of neutral endopeptidase-24.11 (neprilysin) and endothelin-converting enzyme in human prostate cancer cell lines
    • Usmani, B.A., Harden, B., Maitland, N.J., Turner, A.J. Differential expression of neutral endopeptidase-24.11 (neprilysin) and endothelin-converting enzyme in human prostate cancer cell lines. Clin Sci (Lond) 2002, 103 (Suppl. 48): 314S-7.
    • (2002) Clin Sci (Lond) , vol.103 , Issue.SUPPL. 48
    • Usmani, B.A.1    Harden, B.2    Maitland, N.J.3    Turner, A.J.4
  • 26
    • 0033724657 scopus 로고    scopus 로고
    • Role of endothelin-1 in neovascularization of ovarian carcinoma
    • Salani, D., Di Castro, V., Nicotra, M.R. et al. Role of endothelin-1 in neovascularization of ovarian carcinoma. Am J Pathol 2000, 157: 1537-47.
    • (2000) Am J Pathol , vol.157 , pp. 1537-1547
    • Salani, D.1    Di Castro, V.2    Nicotra, M.R.3
  • 27
    • 24944494039 scopus 로고    scopus 로고
    • Role of endothelin axis in progression to aggressive phenotype of prostate adenocarcinoma
    • Godara, G., Cannon, G.W., Cannon, G.M. Jr., Bies, R.R., Nelson, J.B., Pflug, B.R. Role of endothelin axis in progression to aggressive phenotype of prostate adenocarcinoma. Prostate 2005, 65: 27-34.
    • (2005) Prostate , vol.65 , pp. 27-34
    • Godara, G.1    Cannon, G.W.2    Cannon Jr., G.M.3    Bies, R.R.4    Nelson, J.B.5    Pflug, B.R.6
  • 28
    • 0036283452 scopus 로고    scopus 로고
    • Endothelin-1 as a target for therapeutic intervention in prostate cancer
    • Kopetz, E.S., Nelson, J.B., Carducci, M.A. Endothelin-1 as a target for therapeutic intervention in prostate cancer. Invest New Drugs 2002, 20: 173-82.
    • (2002) Invest New Drugs , vol.20 , pp. 173-182
    • Kopetz, E.S.1    Nelson, J.B.2    Carducci, M.A.3
  • 30
    • 0036176126 scopus 로고    scopus 로고
    • Endothelin-1 protects ovarian carcinoma cells against paclitaxel-induced apoptosis: Requirement for Akt activation
    • Del Bufalo, D., Di Castro, V., Biroccio, A. et al. Endothelin-1 protects ovarian carcinoma cells against paclitaxel-induced apoptosis: Requirement for Akt activation. Mol Pharmacol 2002, 61: 524-32.
    • (2002) Mol Pharmacol , vol.61 , pp. 524-532
    • Del Bufalo, D.1    Di Castro, V.2    Biroccio, A.3
  • 31
    • 23244454378 scopus 로고    scopus 로고
    • Endothelin-1 inhibits apoptosis in prostate cancer
    • Nelson, J.B., Udan, M.S., Guruli, G., Pflug, B.R. Endothelin-1 inhibits apoptosis in prostate cancer. Neoplasia 2005, 7: 631-7.
    • (2005) Neoplasia , vol.7 , pp. 631-637
    • Nelson, J.B.1    Udan, M.S.2    Guruli, G.3    Pflug, B.R.4
  • 32
    • 0036670318 scopus 로고    scopus 로고
    • Endothelin-1 acts as a survival factor in ovarian carcinoma cells
    • Del Bufalo, D., Di Castro, V., Biroccio, A. et al. Endothelin-1 acts as a survival factor in ovarian carcinoma cells. Clin Sci (Lond) 2002, 103 (Suppl. 48): 302S-5.
    • (2002) Clin Sci (Lond) , vol.103 , Issue.SUPPL. 48
    • Del Bufalo, D.1    Di Castro, V.2    Biroccio, A.3
  • 33
    • 0035890357 scopus 로고    scopus 로고
    • Endothelin-1 induces tumor proteinase activation and invasiveness of ovarian carcinoma cells
    • Rosano, L., Varmi, M., Salani, D. et al. Endothelin-1 induces tumor proteinase activation and invasiveness of ovarian carcinoma cells. Cancer Res 2001, 61: 8340-6.
    • (2001) Cancer Res , vol.61 , pp. 8340-8346
    • Rosano, L.1    Varmi, M.2    Salani, D.3
  • 35
    • 0042845963 scopus 로고    scopus 로고
    • Endothelin receptor blockade inhibits molecular effectors of Kaposi's sarcoma cell invasion and tumor growth in vivo
    • Rosano, L., Spinella, F., Di Castro, V. et al. Endothelin receptor blockade inhibits molecular effectors of Kaposi's sarcoma cell invasion and tumor growth in vivo. Am J Pathol 2003, 163: 753-62.
    • (2003) Am J Pathol , vol.163 , pp. 753-762
    • Rosano, L.1    Spinella, F.2    Di Castro, V.3
  • 36
    • 1242271205 scopus 로고    scopus 로고
    • Endothelin B receptor blockade inhibits dynamics of cell interactions and communications in melanoma cell progression
    • Bagnato, A., Rosano, L., Spinella, F., Di Castro, V., Tecce, R., Natali, P.G. Endothelin B receptor blockade inhibits dynamics of cell interactions and communications in melanoma cell progression. Cancer Res 2004, 64: 1436-43.
    • (2004) Cancer Res , vol.64 , pp. 1436-1443
    • Bagnato, A.1    Rosano, L.2    Spinella, F.3    Di Castro, V.4    Tecce, R.5    Natali, P.G.6
  • 37
    • 0142135067 scopus 로고    scopus 로고
    • Endothelin-1 decreases gap junctional intercellular communication by inducing phosphorylation of connexin 43 in human ovarian carcinoma cells
    • Spinella, F., Rosano, L., Di Castro, V., Nicotra, M.R., Natali, P.G., Bagnato, A. Endothelin-1 decreases gap junctional intercellular communication by inducing phosphorylation of connexin 43 in human ovarian carcinoma cells. J Biol Chem 2003, 278: 41294-301.
    • (2003) J Biol Chem , vol.278 , pp. 41294-41301
    • Spinella, F.1    Rosano, L.2    Di Castro, V.3    Nicotra, M.R.4    Natali, P.G.5    Bagnato, A.6
  • 38
    • 0033724661 scopus 로고    scopus 로고
    • Endothelin-1 induces an angiogenic phenotype in cultured endothelial cells and stimulates neovascularization in vivo
    • Salani, D., Taraboletti, G., Rosano, L. et al. Endothelin-1 induces an angiogenic phenotype in cultured endothelial cells and stimulates neovascularization in vivo. Am J Pathol 2000, 157: 1703-11.
    • (2000) Am J Pathol , vol.157 , pp. 1703-1711
    • Salani, D.1    Taraboletti, G.2    Rosano, L.3
  • 40
    • 0037008695 scopus 로고    scopus 로고
    • Endothelin-1 induces vascular endothelial growth factor by increasing hypoxia-inducible factor-1 alpha in ovarian carcinoma cells
    • Spinella, F., Rosano, L., Di Castro, V., Natali, P.G., Bagnato, A. Endothelin-1 induces vascular endothelial growth factor by increasing hypoxia-inducible factor-1 alpha in ovarian carcinoma cells. J Biol Chem 2002, 277: 27850-5.
    • (2002) J Biol Chem , vol.277 , pp. 27850-27855
    • Spinella, F.1    Rosano, L.2    Di Castro, V.3    Natali, P.G.4    Bagnato, A.5
  • 41
    • 3242741855 scopus 로고    scopus 로고
    • Inhibition of cyclooxygenase-1 and -2 expression by targeting the endothelin a receptor in human ovarian carcinoma cells
    • Spinella, F., Rosano, L., Di Castro, V., Nicotra, M.R., Natali, P.G., Bagnato, A. Inhibition of cyclooxygenase-1 and -2 expression by targeting the endothelin A receptor in human ovarian carcinoma cells. Clin Cancer Res 2004, 10: 4670-9.
    • (2004) Clin Cancer Res , vol.10 , pp. 4670-4679
    • Spinella, F.1    Rosano, L.2    Di Castro, V.3    Nicotra, M.R.4    Natali, P.G.5    Bagnato, A.6
  • 42
    • 0033988665 scopus 로고    scopus 로고
    • Over-expression of cyclooxygenase-2 in human prostate adenocarcinoma
    • Gupta, S., Srivastava, M., Ahmad, N., Bostwick, D.G., Mukhtar, H. Over-expression of cyclooxygenase-2 in human prostate adenocarcinoma. Prostate 2000, 42: 73-8.
    • (2000) Prostate , vol.42 , pp. 73-78
    • Gupta, S.1    Srivastava, M.2    Ahmad, N.3    Bostwick, D.G.4    Mukhtar, H.5
  • 43
    • 1342310048 scopus 로고    scopus 로고
    • A pilot study of use of the cyclooxygenase-2 inhibitor celecoxib in recurrent prostate cancer after definitive radiation therapy or radical prostatectomy
    • Pruthi, R.S., Derksen, J.E., Moore, D. A pilot study of use of the cyclooxygenase-2 inhibitor celecoxib in recurrent prostate cancer after definitive radiation therapy or radical prostatectomy. BJU Int 2004, 93: 275-8.
    • (2004) BJU Int , vol.93 , pp. 275-278
    • Pruthi, R.S.1    Derksen, J.E.2    Moore, D.3
  • 44
    • 0033010543 scopus 로고    scopus 로고
    • New bone formation in an osteoblastic tumor model is increased by endothelin-1 overexpression and decreased by endothelin a receptor blockade
    • Nelson, J.B., Nguyen, S.H., Wu-Wong, J.R. et al. New bone formation in an osteoblastic tumor model is increased by endothelin-1 overexpression and decreased by endothelin A receptor blockade. Urology 1999, 53: 1063-9.
    • (1999) Urology , vol.53 , pp. 1063-1069
    • Nelson, J.B.1    Nguyen, S.H.2    Wu-Wong, J.R.3
  • 45
    • 0033919232 scopus 로고    scopus 로고
    • Endothelin-1 from prostate cancer cells is enhanced by bone contact which blocks osteoclastic bone resorption
    • Chiao, J.W., Moonga, B.S., Yang, Y.M. et al. Endothelin-1 from prostate cancer cells is enhanced by bone contact which blocks osteoclastic bone resorption. Br J Cancer 2000, 83: 360-5.
    • (2000) Br J Cancer , vol.83 , pp. 360-365
    • Chiao, J.W.1    Moonga, B.S.2    Yang, Y.M.3
  • 46
    • 0141479984 scopus 로고    scopus 로고
    • A causal role for endothelin-1 in the pathogenesis of osteoblastic bone metastases
    • Yin, J.J., Mohammad, K.S., Kakonen, S.M. et al. A causal role for endothelin-1 in the pathogenesis of osteoblastic bone metastases. Proc Natl Acad Sci USA 2003, 100: 10954-9.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 10954-10959
    • Yin, J.J.1    Mohammad, K.S.2    Kakonen, S.M.3
  • 47
    • 0037303203 scopus 로고    scopus 로고
    • Role of endothelin-1 in osteoblastic bone metastases
    • Guise, T.A., Yin, J.J., Mohammad, K.S. Role of endothelin-1 in osteoblastic bone metastases. Cancer 2003, 97: 779-84.
    • (2003) Cancer , vol.97 , pp. 779-784
    • Guise, T.A.1    Yin, J.J.2    Mohammad, K.S.3
  • 48
    • 0035116620 scopus 로고    scopus 로고
    • Expression and localization of endothelin receptors: Implications for the involvement of peripheral glia in nociception
    • Pomonis, J.D., Rogers, S.D., Peters, C.M., Ghilardi, J.R., Mantyh, P.W. Expression and localization of endothelin receptors: Implications for the involvement of peripheral glia in nociception. J Neurosci 2001, 21: 999-1006.
    • (2001) J Neurosci , vol.21 , pp. 999-1006
    • Pomonis, J.D.1    Rogers, S.D.2    Peters, C.M.3    Ghilardi, J.R.4    Mantyh, P.W.5
  • 49
    • 0033967648 scopus 로고    scopus 로고
    • ABT-627, an endothelin ET(A) receptor-selective antagonist, attenuates tactile allodynia in a diabetic rat model of neuropathic pain
    • Jarvis, M.F., Wessale, J.L., Zhu, C.Z. et al. ABT-627, an endothelin ET(A) receptor-selective antagonist, attenuates tactile allodynia in a diabetic rat model of neuropathic pain. Eur J Pharmacol 2000, 388: 29-35.
    • (2000) Eur J Pharmacol , vol.388 , pp. 29-35
    • Jarvis, M.F.1    Wessale, J.L.2    Zhu, C.Z.3
  • 50
    • 19944383762 scopus 로고    scopus 로고
    • Inhibitory effects of a selective endothelin - A receptor antagonist YM598 on endothelin-1-induced potentiation of nociception in formalin-induced and prostate cancer-induced pain models in mice
    • Yuyama, H., Koakutsu, A., Fujiyasu, N. et al. Inhibitory effects of a selective endothelin-A receptor antagonist YM598 on endothelin-1-induced potentiation of nociception in formalin-induced and prostate cancer-induced pain models in mice. J Cardiovasc Pharmacol 2004, 44(Suppl. 1): S479-82.
    • (2004) J Cardiovasc Pharmacol , vol.44 , Issue.SUPPL. 1
    • Yuyama, H.1    Koakutsu, A.2    Fujiyasu, N.3
  • 51
    • 2642513829 scopus 로고    scopus 로고
    • Effects of selective endothelin ET(A) receptor antagonists on endothelin-1-induced potentiation of cancer pain
    • Yuyama, H., Koakutsu, A., Fujiyasu, N. et al. Effects of selective endothelin ET(A) receptor antagonists on endothelin-1-induced potentiation of cancer pain. Eur J Pharmacol 2004, 492: 177-82.
    • (2004) Eur J Pharmacol , vol.492 , pp. 177-182
    • Yuyama, H.1    Koakutsu, A.2    Fujiyasu, N.3
  • 52
    • 0041888477 scopus 로고    scopus 로고
    • Endothelin-B receptor activation triggers an endogenous analgesic cascade at sites of peripheral injury
    • Khodorova, A., Navarro, B., Jouaville, L.S. et al. Endothelin-B receptor activation triggers an endogenous analgesic cascade at sites of peripheral injury. Nat Med 2003, 9: 1055-61.
    • (2003) Nat Med , vol.9 , pp. 1055-1061
    • Khodorova, A.1    Navarro, B.2    Jouaville, L.S.3
  • 53
    • 2942672459 scopus 로고    scopus 로고
    • Endothelin and the tumorigenic component of bone cancer pain
    • Peters, C.M., Lindsay, T.H., Pomonis, J.D. et al. Endothelin and the tumorigenic component of bone cancer pain. Neuroscience 2004, 126: 1043-52.
    • (2004) Neuroscience , vol.126 , pp. 1043-1052
    • Peters, C.M.1    Lindsay, T.H.2    Pomonis, J.D.3
  • 54
    • 0036671886 scopus 로고    scopus 로고
    • Pharmacology of endothelin receptor antagonists ABT-627, ABT-546, A-182086 and A-192621: In vitro studies
    • Wu-Wong, J.R., Dixon, D.B., Chiou, W.J. et al. Pharmacology of endothelin receptor antagonists ABT-627, ABT-546, A-182086 and A-192621: In vitro studies. Clin Sci (Lond) 2002, 103(Suppl. 48): 107S-11.
    • (2002) Clin Sci (Lond) , vol.103 , Issue.SUPPL. 48
    • Wu-Wong, J.R.1    Dixon, D.B.2    Chiou, W.J.3
  • 55
    • 10344256275 scopus 로고    scopus 로고
    • Effect of ketoconazole (KET) on the pharmacokinetics (PK) of atrasentan (ABT-627, ATN)
    • New Orleans, Abst. 4727
    • Zhu, T., Andre, A., Facey, I. et al. Effect of ketoconazole (KET) on the pharmacokinetics (PK) of atrasentan (ABT-627, ATN). 40th American Society of Clinical Oncology, Annual Meeting, New Orleans 2004, Abst. 4727.
    • (2004) 40th American Society of Clinical Oncology, Annual Meeting
    • Zhu, T.1    Andre, A.2    Facey, I.3
  • 58
    • 10344257624 scopus 로고    scopus 로고
    • Pharmacogenetic metaanalysis suggests that atrasentan is an organic anion transport protein C substrate
    • Katz, D.A., Grimm, D.R., Carr, R. et al. Pharmacogenetic metaanalysis suggests that atrasentan is an organic anion transport protein C substrate. Clin Pharm Ther 2004, 75: 94.
    • (2004) Clin Pharm Ther , vol.75 , pp. 94
    • Katz, D.A.1    Grimm, D.R.2    Carr, R.3
  • 59
  • 60
    • 0037089676 scopus 로고    scopus 로고
    • Atrasentan, an endothelin-receptor antagonist for refractory adenocarcinomas: Safety and pharmacokinetics
    • Carducci, M.A., Nelson, J.B., Bowling, M.K. et al. Atrasentan, an endothelin-receptor antagonist for refractory adenocarcinomas: Safety and pharmacokinetics. J Clin Oncol 2002, 20: 2171-80.
    • (2002) J Clin Oncol , vol.20 , pp. 2171-2180
    • Carducci, M.A.1    Nelson, J.B.2    Bowling, M.K.3
  • 61
    • 0041464540 scopus 로고    scopus 로고
    • Phase I dose-escalation study of the safety and pharmacokinetics of atrasentan: An endothelin receptor antagonist for refractory prostate cancer
    • Zonnenberg, B.A., Groenewegen, G., Janus, T.J. et al. Phase I dose-escalation study of the safety and pharmacokinetics of atrasentan: An endothelin receptor antagonist for refractory prostate cancer. Clin Cancer Res 2003, 9: 2965-72.
    • (2003) Clin Cancer Res , vol.9 , pp. 2965-2972
    • Zonnenberg, B.A.1    Groenewegen, G.2    Janus, T.J.3
  • 62
    • 3042851918 scopus 로고    scopus 로고
    • Dose-ranging study of the safety and pharmacokinetics of atrasentan in patients with refractory malignancies
    • Ryan, C.W., Vogelzang, N.J., Vokes, E.E. et al. Dose-ranging study of the safety and pharmacokinetics of atrasentan in patients with refractory malignancies. Clin Cancer Res 2004, 10: 4406-11.
    • (2004) Clin Cancer Res , vol.10 , pp. 4406-4411
    • Ryan, C.W.1    Vogelzang, N.J.2    Vokes, E.E.3
  • 63
    • 4043179333 scopus 로고    scopus 로고
    • Effects of atrasentan on disease progression and biological markers in men with metastatic hormone-refractory prostate cancer: Phase 3 study
    • New Orleans, Abst. 4508
    • Carducci, M.A., Nelson, J.B., F. Saad, F. et al. Effects of atrasentan on disease progression and biological markers in men with metastatic hormone-refractory prostate cancer: Phase 3 study. 40th American Society of Clinical Oncology, Annual Meeting, New Orleans 2004, Abst. 4508.
    • (2004) 40th American Society of Clinical Oncology, Annual Meeting
    • Carducci, M.A.1    Nelson, J.B.2    Saad, F.3
  • 64
    • 0037441843 scopus 로고    scopus 로고
    • Effect of endothelin - A receptor blockade with atrasentan on tumor progression in men with hormone-refractory prostate cancer: A randomized, phase II, placebo-controlled trial
    • Carducci, M.A., Padley, R.J., Breul, J. et al. Effect of endothelin-A receptor blockade with atrasentan on tumor progression in men with hormone-refractory prostate cancer: A randomized, phase II, placebo-controlled trial. J Clin Oncol 2003, 21: 679-89.
    • (2003) J Clin Oncol , vol.21 , pp. 679-689
    • Carducci, M.A.1    Padley, R.J.2    Breul, J.3
  • 65
    • 0037364732 scopus 로고    scopus 로고
    • Suppression of prostate cancer induced bone remodeling by the endothelin receptor a antagonist atrasentan
    • Nelson, J.B., Nabulsi, A.A., Vogelzang, N.J. et al. Suppression of prostate cancer induced bone remodeling by the endothelin receptor A antagonist atrasentan. J Urol 2003, 169: 1143-9.
    • (2003) J Urol , vol.169 , pp. 1143-1149
    • Nelson, J.B.1    Nabulsi, A.A.2    Vogelzang, N.J.3


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