The αvβ6 integrin plays a role in compromised epidermal wound healing

Wound Repair and Regeneration

Volumn 14, Issue 3, 2006, Pages 289-297

  AlDahlawi, Salwa ^a   Eslami, Ameneh ^a   Häkkinen, Lari ^a   Larjava, Hannu S ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA5 INTEGRIN; BETA6 INTEGRIN; HYDROCORTISONE; ALPHAVBETA6 INTEGRIN; COLLAGEN TYPE 4; DRUG DERIVATIVE; HYDROCORTISONE SODIUM SUCCINATE; INTEGRIN; TUMOR ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL MIGRATION; CONTROLLED STUDY; EPIDERMIS CELL; EPITHELIUM CELL; EXTRACELLULAR MATRIX; FETUS DEVELOPMENT; GENE OVEREXPRESSION; KERATINOCYTE; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; SKIN INJURY; WOUND HEALING; AGING; ANIMAL; CELL MOTION; GRANULATION TISSUE; IMMUNOHISTOCHEMISTRY; INJURY; METABOLISM; MOUSE MUTANT; PATHOLOGY; PHYSIOLOGY; SKIN;

AGING; ANIMALS; ANTIGENS, NEOPLASM; CELL MOVEMENT; COLLAGEN TYPE IV; GRANULATION TISSUE; HYDROCORTISONE; IMMUNOHISTOCHEMISTRY; INTEGRINS; MICE; MICE, KNOCKOUT; SKIN; WOUND HEALING;

EID: 33745524940     PISSN: 10671927     EISSN: 1524475X     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2006.00123.x     Document Type: Article

References (43)

1. Breuss JM, Gallo J, DeLisser HM, Klimanskaya IV, Folkesson HG, Pittet JF, Nishimura SL, Aldape K, Landers DV, Carpenter W, Gillet N, Sheppard D, Matthay MA, Albelda SM, Kramer RH, Pytela R. Expression of the beta 6 integrin subunit in development, neoplasia and tissue repair suggests a role in epithelial remodeling. J Cell Sci 1995; 108: 2241-51.
2. Häkkinen L, Hildebrand HC, Berndt A, Kosmehl H, Larjava H. Immunolocalization of tenascin-C, alpha9 integrin subunit, and alpha v beta 6 integrin during wound healing in human oral mucosa. J Histochem Cytochem 2000; 48: 985-98.
3. Huang X, Wu J, Spong S, Sheppard D. The integrin alphavbeta6 is critical for keratinocyte migration on both its known ligand, fibronectin, and on vitronectin. J Cell Sci 1998; 111: 2189-95.
4. Busk M, Pytela R, Sheppard D. Characterization of the integrin alphav beta6 as a fibronectin-binding protein. J Biol Chem 1992; 267: 5790-6.
5. Haapasalmi K, Zhang K, Tonnesen M, Olerud J, Sheppard D, Salo T, Kramer R, Clark RA, Uitto VJ, Larjava H. Keratinocytes in human wounds express alphav beta6 integrin. J Invest Dermatol 1996; 106: 42-8.
6. Huang XZ, Wu JF, Cass D, Erle DJ, Corry D, Young SG, Farese RV Jr, Sheppard D. Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin. J Cell Biol 1996; 133: 921-8.
7. Huang X, Wu J, Zhu W, Pytela R, Sheppard D. Expression of the human integrin beta6 subunit in alveolar type II cells and bronchiolar epithelial cells reverses lung inflammation in beta6 knockout mice. Am J Respir Cell Mol Biol 1998; 19: 636-42.
8. Munger S, Huang X, Kawakatsu H. The integrin alphavbeta6 binds and activates latent TGF beta1: a mechanism for regulating pulmonary inflammation and fibrosis. Cell 1999; 96: 319-28.
9. Häkkinen L, Koivisto L, Gardner H, Saarialho-Kere U, Carroll JM, Lakso M, Rauvala H, Laato M, Heino J, Larjava H. Increased expression of beta6 integrin in skin leads to spontaneous development of chronic wounds. Am J Pathol 2004; 164: 229-42.
10. Elenkov IJ, Chrousos GP. Stress hormones, proinflammatory and antiinflammatory cytokines, and autoimmunity. Ann NY Acad Sci 2002; 966: 290-303.
11. Salmela K. Comparison of the effects of methylprednisolone and hydrocortisone on granulation tissue development. An experimental study in rat. Scand J Plast Reconstr Surg 1981; 15: 87-91.
12. Dostal GH, Gamelli RL. The differential effect of corticosteroids on wound disruption strength in mice. Arch Surg 1990; 125: 636-40.
13. Lenco W, McKnight M, Macdonald AS. Effects of cortisone acetate, methylprednisolone and medroxyprogesterone on wound contracture and epithelization in rabbits. Ann Surg 1975; 181: 67-73.
14. Leibovich SJ, Ross R. The role of the macrophage in wound repair. A study with hydrocortisone and antimacrophage serum. Am J Pathol 1975; 78: 71-100.
15. Beer HD, Fassler R, Werner S. Glucocorticoid regulated gene expression during cautaneous wound repair. Vitm Horm 2000; 59: 217-39.
16. Frank S, Madlener M, Werner S. Transforming growth factors beta1, beta2, and beta3 and their receptors are differentially regulated during normal and impaired wound healing. J Biol Chem 1996; 271: 10188-93.
17. Beck LS, Deguzman L, Lee WP, Xu Y, McFatridge LA, Amento EP. TGF-beta1 accelerates wound healing: reversal of steroid-impaired healing in rats and rabbits. Growth Factors 1991; 5: 295-304.
18. Beck LS, DeGuzman L, Lee WP, Xu Y, Siegel MW, Amento EP. One systemic administration of transforming growth factor-beta1 reverses age- or glucocorticoid-impaired wound healing. J Clin Invest 1993; 92: 2841-9.
19. Marucha PT, Kiecolt-Glaser JK, Favagehi M. Mucosal wound healing is impaired by examination stress. Psychosom Med 1998; 60: 362-5.
20. Padgett DA, Marucha PT, Sheridan JF. Restraint stress slows cutaneous wound healing in mice. Brain Behav Immun 1998; 12: 64-73.
21. Sakai LY, Engvall E, Hollister DW, Burgeson RE. Production and characterization of a monoclonal antibody to human type IV collagen. Am J Pathol 1982; 108: 310-8.
22. Scheid A, Meuli M, Gassmann M, Wenger RH. Genetically modified mouse models in studies on cutaneous wound healing. Exp Physiol 2000; 85: 687-704.
23. Snowden JM. Wound closure: an analysis of the relative contributions of contraction and epithelialization. J Surg Res 1984; 37: 453-63.
24. Larjava H, Koivisto L, Häkkinen L. Keratinocyte interactions with fibronectin during wound healing. In: Heino J, Kähäri V-M, editors. Cell invasion. Georgetown: Eurekah.com Landes Biosciences, 2002: 42-64.
25. Van de Kerkhof PC, Van Bergen B, Spruijt K, Kuiper JP. Age-related changes in wound healing. Clin Exp Dermatol 1994; 19: 369-74.
26. Mogford JE, Sisco M, Bonomo SR, Robinson AM, Mustoe TA. Impact of aging on gene expression in a rat model of ischemic cutaneous wound healing. J Surg Res 2004; 118: 190-6.
27. Ballas CB, Davidson JM. Delayed wound healing in aged rats is associated with increased collagen gel remodeling and contraction by skin fibroblasts, not with differences in apoptotic or myofibroblast cell populations. Wound Rep Reg 2001; 9: 223-37.
28. Gosain A, DiPietro LA. Aging and wound healing. World J Surg 2004; 28: 321-6.
29. Ashcroft GS, Horan MA, Ferguson MW. Aging is associated with reduced deposition of specific extracellular matrix components, an upregulation of angiogenesis, and an altered inflammatory response in a murine incisional wound healing model. J Invest Dermatol 1997; 108: 430-7.
30. Swift ME, Kleinman HK, DiPietro LA. Impaired wound repair and delayed angiogenesis in aged mice. Lab Invest 1999; 79: 1479-87.
31. Koivisto L, Larjava H, Häkkinen L, Uitto VJ, Heino J, Larjava H. Different integrins mediate cell spreading, haptotaxis and lateral migration of HaCaT keratinocytes on fibronectin. Cell Adhes Commun 1999; 7: 245-57.
32. Annes JP, Chen Y, Munger JS, Rifkin DB. Integrin alphav-betao-mediated activation of latent TGF-beta requires the latent TGF-beta binding protein-1. J Cell Biol 2004; 165: 723-34.
33. Swift ME, Burns AL, Gray KL, DiPietro LA. Age-related alterations in the inflammatory response to dermal injury. J Invest Dermatol 2001; 117: 1027-35.
34. Wu L, Xia YP, Roth SI, Gruskin E, Mustoe TA. Transforming growth factor-beta1 fails to stimulate wound healing and impairs its signal transduction in an aged ischemic ulcer model: importance of oxygen and age. Am J Pathol 1999; 154: 301-9.
35. Schmid P, Kunz S, Cerletti N, McMaster G, Cox D. Injury induced expression of TGF-beta 1 mRNA is enhanced by exogenously applied TGF-beta S. Biochem Biophys Res Commun 1993; 194: 399-406.
36. Ashcroft GS, Dodsworth J, van Boxtel E, Tarnuzzer RW, Horan MA, Schultz GS, Ferguson MW. Estrogen accelerates cutaneous wound healing associated with an increase in TGF-beta1 levels. Nat Med 1997; 3: 1209-15.
37. Sheppard D. Integrin-mediated activation of transforming growth factor-beta(1) in pulmonary fibrosis. Chest 2001; 120 (Suppl): 49S-53S.
38. Durmus M, Karaaslan E, Ozturk E, Gulec M, Iraz M, Edali N, Ersoy MO. The effects of single-dose dexamethasone on wound healing in rats. Anesth Analg 2003; 97: 1377-80.
39. Ehrlich HP, Hunt TK. Effects of cortisone and vitamin A on wound healing. Ann Surg 1968; 167: 324-8.
40. Sandberg N. Time relationship between administration of cortisone and wound healing in rats. Acta Chir Scand 1964; 127: 446-55.
41. Rheinwald JG, Green H. Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells. Cell 1975; 6: 331-43.
42. Wen FQ, Kohyama T, Skold CM, Zhu YK, Liu X, Romberger DJ, Stoner J, Rennard SI. Glucocorticoids modulate TGF-beta production. Inflammation 2002; 26: 279-90.
43. Pierce GF, Mustoe TA, Lingelbach J, Masakowski VR, Gramates P, Deuel TF. Transforming growth factor beta reverses the glucocorticoid-induced wound-healing deficit in rats: possible regulation in macrophages by platelet-derived growth factor. Proc Natl Acad Sci USA 1989; 86: 2229-33.