Formulation and optimization of mouth dissolve tablets containing rofecoxib solid dispersion

AAPS PharmSciTech

Volumn 7, Issue 2, 2006, Pages

  Sammour, Omaima A ^a   Hammad, Mohammed A ^a   Megrab, Nagia A ^a   Zidan, Ahmed S ^a,b,c  

^a Zagazig University   (Egypt)

^b HOWARD UNIVERSITY   (United States)

^c CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Factorial design; Mouth dissolve tablets; Polyvinyl pyrrolidone K30; Rofecoxib; Solid dispersion; Solvent method

Indexed keywords

CAMPHOR; CROSPOVIDONE; DISINTEGRATING AGENT; DRUG CARRIER; DRUG SOLVENT; POLYMER; POVIDONE; ROFECOXIB; LACTONE; SULFONE;

ARTICLE; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DRUG QUALITY; DRUG SOLUBILITY; EVAPORATION; FACTORIAL DESIGN; HYDROPHOBICITY; INFRARED SPECTROSCOPY; MULTIPLE REGRESSION; PREDICTION; PROCESS OPTIMIZATION; STATISTICAL MODEL; TABLET DISINTEGRATION TIME; TABLET FORMULATION; TABLET FRIABILITY; X RAY DIFFRACTION; ABSORPTION; CHEMISTRY; COMPARATIVE STUDY; DIFFUSION; HUMAN; METHODOLOGY; MOUTH; ORAL DRUG ADMINISTRATION; QUALITY CONTROL; SALIVA; SOLUBILITY; TABLET;

ABSORPTION; ADMINISTRATION, ORAL; CHEMISTRY, PHARMACEUTICAL; DIFFUSION; DRUG CARRIERS; HUMANS; LACTONES; MOUTH; POVIDONE; QUALITY CONTROL; SALIVA; SOLUBILITY; SULFONES; TABLETS;

EID: 33745516475     PISSN: 15309932     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/pt070231     Document Type: Article

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