Characteristics of rofecoxib-polyethylene glycol 4000 solid dispersions and tablets based on solid dispersions

Pharmaceutical Development and Technology

Volumn 10, Issue 4, 2005, Pages 467-477

  Liu, Chengsheng ^a   Desai, Kashappa Goud ^b  

^a OCEAN UNIVERSITY OF CHINA   (China)

^b Korea University   (South Korea)

Author keywords

Anti inflammatory activity; Dissolution rate; Mean dissolution time; PEG 4000; Rofecoxib; Solid dispersions; Solubility; Tablets

Indexed keywords

AEROSIL; LACTOSE; MACROGOL 4000; MAGNESIUM STEARATE; MICROCRYSTALLINE CELLULOSE; ROFECOXIB; STARCH; WATER;

ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; COMPRESSION; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSIBLE TABLET; DRUG SOLUBILITY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; HARDNESS; INFRARED SPECTROSCOPY; MALE; MATHEMATICAL COMPUTING; NONHUMAN; PAW EDEMA; PRIORITY JOURNAL; RAT; REPRODUCIBILITY; SCANNING ELECTRON MICROSCOPY; SOLID STATE; X RAY DIFFRACTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CALORIMETRY, DIFFERENTIAL SCANNING; EDEMA; FEMALE; KINETICS; LACTONES; MALE; MICROSCOPY, ELECTRON, SCANNING; POLYETHYLENE GLYCOLS; RATS; SOLUBILITY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; SULFONES; TABLETS; TIME FACTORS; X-RAY DIFFRACTION;

EID: 28844465151     PISSN: 10837450     EISSN: 10979867     Source Type: Journal    
DOI: 10.1080/10837450500299701     Document Type: Article

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