Hypercalcemia in rheumatoid arthritis: Relationship with disease activity and bone metabolism

Rheumatology International

Volumn 26, Issue 10, 2006, Pages 908-915

  Oelzner, Peter ^a   Lehmann, Gabriele ^a   Eidner, Thorsten ^a   Franke, Sybille ^a   Müller, Andreas ^a   Wolf, Gunter ^a   Hein, Gert ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

Bone mineral density; Disease activity; Ionized calcium; Rheumatoid arthritis

Indexed keywords

C REACTIVE PROTEIN; CALCIFEDIOL; CALCITRIOL; CALCIUM ION; DEOXYPYRIDINOLINE; INTERLEUKIN 6; OSTEOCALCIN; PARATHYROID HORMONE; PYRIDINOLINE; VITAMIN D DERIVATIVE;

ADULT; AGED; ARTICLE; BONE DENSITY; BONE METABOLISM; CALCIUM BLOOD LEVEL; CONTROLLED STUDY; CROSS LINKING; DISEASE ACTIVITY; DISEASE ASSOCIATION; DUAL ENERGY X RAY ABSORPTIOMETRY; ERYTHROCYTE SEDIMENTATION RATE; FEMALE; FEMUR NECK; HORMONE SYNTHESIS; HUMAN; HYPERCALCEMIA; LUMBAR SPINE; MAJOR CLINICAL STUDY; MALE; OSTEOLYSIS; PARATHYROID HORMONE RELEASE; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; URINARY EXCRETION; VITAMIN BLOOD LEVEL;

ABSORPTIOMETRY, PHOTON; ADOLESCENT; ADULT; AGED; AMINO ACIDS; ARTHRITIS, RHEUMATOID; BLOOD SEDIMENTATION; BONE DENSITY; BONE DISEASES, METABOLIC; C-REACTIVE PROTEIN; CALCIFEDIOL; CALCITRIOL; CALCIUM; CROSS-LINKING REAGENTS; DENSITOMETRY, X-RAY; FEMALE; FEMUR NECK; HUMANS; HYPERCALCEMIA; INTERLEUKIN-6; LUMBAR VERTEBRAE; MALE; MIDDLE AGED; OSTEOCALCIN; PARATHYROID HORMONE; SERUM ALBUMIN;

EID: 33745509177     PISSN: 01728172     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00296-005-0095-y     Document Type: Article

References (51)

1. Gough A, Sambrook P, Devlin J, Huisson A, Njeh C, Robbins S, Nguyen T, Emery P (1998) Osteoclastic activation is the principal mechanism leading to secondary osteoporosis in rheumatoid arthritis. J Rheumatol 25:1282-1289
2. Romas E, Gillespie MT, Martin TJ (2002) Involvement of receptor activator of NfkappaB ligand and tumor necrosis factor-alpha in bone destruction in rheumatoid arthritis. Bone 30:340-346
3. Shimizu S, Shiozawa S, Shiozawa K, Imura S, Fujita T (1985) Quantitative histologic studies on the pathogenesis of periarticular osteoporosis in rheumatoid arthritis. Arthritis Rheum 28:25-31
4. Kröger H, Arnala I, Rehnberg V, Hamalainen M, Alhava E (1994) Histomorphometry of periarticular bone in rheumatoid arthritis. Ann Chir Gynaecol 83:56-62
5. Tanabe M, Ochi T, Tomita T, Suzuki R, Sakata T, Shimaoka Y, Nakagawa S, Ono K (1994) Remarkable elevation of interleukin 6 and interleukin 8 levels in the bone marrow serum of patients with rheumatoid arthritis. J Rheumatol 21:830-835
6. Toritsuka Y, Nakamura N, Lee SB, Hashimoto J, Yasui N, Shino K, Ochi T (1997) Osteoclastogenesis in iliac bone marrow of patients with rheumatoid arthritis. J Rheumatol 24:1690-1696
7. Guise TA, Kozlow WM, Heras-Herzig A, Padalecki SS, Yin JJ, Chirgwin JM (2005) Molecular mechanisms of breast cancer metastases to bone. Clin Breast Cancer 5(Suppl 2):46-53
8. Roux S, Mariette X (2004) The high rate of bone resorption in multiple myeloma is due to RANK (receptor activator of nuclear factor-kappaB) and RANK ligand expression. Leukoc Lymphoma 45:1111-1118
9. Lai FP, Cole-Sinclair M, Cheng WJ, Quinn JM, Gillespie MT, Sentry JW, Schneider HG (2004) Myeloma cells can directly contribute to the pool of RANKL in bone bypassing the classic stromal and osteoblast pathway of osteoclast stimulation. Br J Haematol 126:192-201
10. Giuliani N, Colla S, Morandi F, Rizzoli V (2004) The RANK/RANK ligand system is involved in interleukin-6 and interleukin-11 upregulation by human myeloma cells in the bone marrow microenvironment. Haematologica 89:1118-1123
11. Bendre M, Gaddy D, Nicholas RW, Suva LJ (2003) Breast cancer metastasis to bone: it is not all about PTHrP. Clin Orthop Relat Res 415(Suppl):39-45
12. Barton BE (2005) Interleukin-6 and new strategies for the treatment of cancer, hyperproliferative diseases and paraneoplastic syndromes. Expert Opin Ther Targets 9:737-752
13. Abe M, Hiura K, Wilde J, Shioyasono A, Moriyama K, Hashimoto T, Kido S, Oshima T, Shibata H, Ozaki S, Inoue D, Matsumoto T (2004) Osteoclasts enhance myeloma cell growth and survival via cell-cell contact: a vicious cycle between bone destruction and myeloma expansion. Blood 104:2484-2491
14. Miyazawa K, Mori A, Yamamoto K, Okudaira H (1998) Constitutive transcription of the human interleukin-6 gene by rheumatoid synoviocytes: spontaneous activation of NF-kappaB and CBF1. Am J Pathol 152:793-803
15. Sung JY, Hong JH, Kang HS, Choi I, Lim SD, Lee JK, Seok JH, Lee JH, Hur GM (2000) Methotrexate suppresses the interleukin-6 induced generation of reactive oxygen species in the synoviocytes of rheumatoid arthritis. Immunopharmacology 47:35-44
16. Kohno H, Shigeno C, Kasai R, Akiyama H, Iida H, Tsuboyama T, Sato K, Konishi J, Nakamura T (1997) Synovial fluids from patients with osteoarthritis and rheumatoid arthritis contain high levels of parathyroid hormone-related peptide. J Bone Miner Res 12:847-854
17. Funk JL, Cordaro LA, Wie H, Benjamin JB, Yocum DE (1998) Synovium as a source of increased amino-terminal parathyroid hormone-related protein expression in rheumatoid arthritis. A possible role for locally produced parathyroid hormone-related protein in the pathogenesis of rheumatoid arthritis. J Clin Invest 101:1362-1371
18. Horiuchi T, Yoshida T, Koshihara Y, Sakamoto H, Kanai H, Yamamoto S, Ito H (1999) The increase of parathyroid hormone-related peptide and cytokine levels in synovial fluid of elderly rheumatoid arthritis and osteoarthritis. Endocr J 46:643-649
19. Hofbauer LC, Khosla S, Dunstan CR, Lacey DL, Boyle WJ, Riggs BL (2000) The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption. J Bone Miner Res 15:2-12
20. Gravallese EM, Manning C, Tsay A, Naito A, Pan C, Amento E, Goldring SR (2000) Synovial tissue in rheumatoid arthritis is a source of osteoclast differentiation factor. Arthritis Rheum 43:250-258
21. Meinecke I, Rutkauskaite E, Gay S, Pap T (2005) The role of synovial fibroblasts in mediating joint destruction in rheumatoid arthritis. Curr Pharm Des 11:563-568
22. Niwa Y, Iio A, Niwa G, Sakane T, Tsunematsu T, Kanoh T (1990) Serum albumin metabolism in rheumatic diseases: relationship to corticosteroids and peptic ulcer. J Clin Lab Immunol 31:11-16
23. Huang Y, Shinzawa H, Togashi H, Takahashi T, Kuzumaki T, Otsu K, Ishikawa K (1995) Interleukin-6 down-regulates expressions of the aldolase B and albumin genes through a pathway involving the activation of tyrosine kinase. Arch Biochem Biophys 320:203-209
24. Arnett FC, Edworthy SM, Bloch DA (1988) The American Rheumatism Association 1987 revised criteria for classification of rheumatoid arthritis. Arthritis Rheum 31:315-324
25. Müller A, Hein G, Franke S, Herrmann D, Henzgen S, Roth A, Stein G (1996) Quantitative analysis of pyridinium cross-links of collagen in the synovial fluid of patients with rheumatoid arthritis using high-performance liquid chromatography. Rheumatol Int 16:23-28
26. Reed A, Haugen M, Pachmann LM, Langman CB (1990) Abnormilities in serum osteocalcin values in children with chronic rheumatic diseases. J Pediatr 116:574-580
27. Broadus AE, Silverberg SJ, Lemann J Jr (1993) Calcium, magnesium and phosphorus homeostasis. In: Favus MJ (ed) Primer on the metabolic bone diseases and disorders of mineral metabolism. Raven Press, New York, NY, pp 29-39
28. Need AG, Morris HA, Horowitz M, Scopacasa E, Nordin BE (1998) Intestinal calcium absorption in men with spinal osteoporosis. Clin Endocrinol 48:163-168
29. Oelzner P, Müller A, Deschner F, Hüller M, Abendroth K, Hein G, Stein G (1998) Relationship between disease activity and serum levels of vitamin D metabolites and PTH in rheumatoid arthritis. Calcif Tissue Int 62:193-198
30. Morris HA, Need AG, O'Loughlin PD, Horowitz M, Bridges A, Nordin BE (1990) Malabsorption of calcium in corticosteroid-induced osteoporosis. Calcif Tissue Int 46:305-308
31. Bauer J, Lengyel G, Thung SN, Jonas U, Gerok W, Acs G (1991) Human fetal hepatocytes respond to inflammatory mediators and excrete bile. Hepatology 13:1131-1141
32. Kotake S, Sato K, Kim KJ, Takahashi N, Udagawa N, Nakamura I, Yamaguchi A, Kishimoto T, Suda T, Kashiwazaki S (1996) Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation. J Bone Miner Res 11:88-95
33. Hayashida K, Ochi T, Fujimoto M, Owaki H, Shimaoka Y, Ono K, Matsumoto K (1992) Bone marrow changes in adjuvant-induced and collagen-induced arthritis. Interleukin-1 and interleukin-6 activity and abnormal myelopoiesis. Arthritis Rheum 35:241-245
34. Suzuki Y, Tanihara M, Ichikawa Y, Osanai A, Nakagawa M, Ide M, Mizushima Y (1995) Periarticular osteopenia in adjuvant induced arthritis: role of interleukin-1 in decreased osteogenic and increased resorptive potential of bone marrow cells. Ann Rheum Dis 54:484-490
35. Sugiyama T (2001) Involvement of interleukin-6 and prostaglandin E2 in periarticular osteoporosis of postmenopausal women with rheumatoid arthritis. J Bone Miner Metab 19:89-96
36. Toffaletti J, Abrams B (1989) Effects of in vivo and in vitro production of lactic acid on ionized, protein-bound, and complex-bound calcium in blood. Clin Chem 35:935-938
37. Farr M, Garvey K, Bold AM, Kendall MJ, Bacon PA (1985) Significance of the hydrogen ion concentration in synovial fluid in rheumatoid arthritis. Clin Exp Rheumatol 3:99-104
38. Chen RA, Goodman WG (2004) Role of calcium-sensing receptor in parathyroid gland physiology. Am J Physiol Renal Physiol 286:1005-1011
39. Ebert R, Jovanovic M, Ulmer M, Schneider D, Meissner-Weigl J, Adamski J, Jakob F (2004) Down-regulation by nuclear factor kappaB of human 25-hydroxyvitamin D3 1 alpha-hydroxylase promoter. Mol Endocrinol 18:2440-2450
40. Nielsen PK, Rasmussen AK, Butters R, Feldt-Rasmussen U, Bendtzen K, Diaz R, Brown EM, Olgaard K (1997) Inhibition of PTH secretion by interleukin-1 beta in bovine parathyroid glands in vitro is associated with an up-regulation of the calcium-sensing receptor mRNA. Biochem Biophys Res Commun 238:880-885
41. Carlstedt E, Ridefelt P, Lind L, Rastad J (1999) Interleukin-6 induced suppression of bovine parathyroid hormone secretion. Biosci Rep 19:35-42
42. Kotake S, Higaki M, Sato K, Himeno S, Morita H, Kim KJ, Nara N, Miyasaka N, Nishioka K, Kashiwazaki S (1992) Detection of myeloid precursors (granulocyte/macrophage colony forming units) in the bone marrow adjacent to rheumatoid arthritis joints. J Rheumatol 19:1511-1516
43. Fujikawa Y, Sabokbar A, Neale S, Athanasou NA (1996) Human osteoclast formation and bone resorption by monocytes and synovial macrophages in rheumatoid arthritis. Ann Rheum Dis 55:816-822
44. Hirohata S, Yanagida T, Itoh K, Nakamura H, Yoshino S, Tomita T, Ochi T (1996) Accelerated generation of CD14+ monocyte-lineage cells from the bone marrow of rheumatoid arthritis patients. Arthritis Rheum 39:836-843
45. Schulze-Koops H, Davis LS, Kavanaugh AF, Lipsky PE (1997) Elevated cytokine messenger RNA levels in the peripheral blood of patients with rheumatoid arthritis suggest different degrees of myeloid cell activation. Arthritis Rheum 40:639-647
46. Suzuki Y, Nishikaku F, Nakatuka M, Koga Y (1998) Osteoclast-like cells in murine collagen induced arthritis. J Rheumatol 25:1154-1160
47. Hirayama T, Danks L, Sabokbar A, Athanasou NA (2002) Osteoclast formation and activity in the pathogenesis of osteoporosis in rheumatoid arthritis. Rheumatology 41:1232-1239
48. Bornefalk E, Ljunghall S, Lindh E, Bengtson O, Johansson AG, Ljunggren O (1997) Regulation of interleukin-6 secretion from mononuclear blood cells by extracellular calcium. J Bone Miner Res 12:228-233
49. Reeve J, Loftus J, Hesp R, Ansell BM, Wright DJ, Woo PM (1993) Biochemical prediction of changes in spinal bone mass in juvenile chronic (or rheumatoid) arthritis treated with glucocorticoids. J Rheumatol 20:1189-1195
50. Cortet B, Flipo RM, Pigny P, Duquesnoy B, Boersma A, Marchandise X, Delcambre B (1998) Is bone turnover a determinant of bone mass in rheumatoid arthritis. J Rheumatol 25:2339-2344
51. Cortet B, Guyot MH, Solau E, Pigny P, Dumoulin F, Flipo RM, Marchandise X, Delcambre B (2000) Factors influencing bone loss in rheumatoid arthritis: a longitudinal study. Clin Exp Rheumatol 18:683-690