N-acetylcysteine is a highly available precursor for cysteine in the neonatal piglet receiving parenteral nutrition

Journal of Parenteral and Enteral Nutrition

Volumn 30, Issue 2, 2006, Pages 133-142

  Shoveller, Anna K ^a,f   Brunton, Janet A ^b   Brand, Ortrud ^e   Pencharz, Paul B ^a,c,d   Ball, Ronald O ^a,c,d  

^a UNIVERSITY OF ALBERTA   (Canada)

^b MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

^c HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

^e Fresenius Kabi Deutschland GmbH   (Germany)

^f UNIVERSITY OF GUELPH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; CYSTEINE; METHIONINE; NITROGEN; AMINO ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; CATHETERIZATION; CONTROLLED STUDY; DRUG BIOAVAILABILITY; FEMORAL ARTERY; INFANT DISEASE; JUGULAR VEIN; MALE; MOLECULAR STABILITY; NONHUMAN; PARENTERAL NUTRITION; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; SWINE; WEIGHT GAIN; ANIMAL; BIOAVAILABILITY; BIOSYNTHESIS; BLOOD; METABOLISM; NEWBORN; URINE;

ACETYLCYSTEINE; AMINO ACIDS; ANIMALS; ANIMALS, NEWBORN; BIOLOGICAL AVAILABILITY; CYSTEINE; METHIONINE; NITROGEN; PARENTERAL NUTRITION; SWINE; WEIGHT GAIN;

EID: 33745503793     PISSN: 01486071     EISSN: None     Source Type: Journal    
DOI: 10.1177/0148607106030002133     Document Type: Article

References (44)

1. Zlotkin SH, Anderson GH. The development of cystathionase activity during the first year of life. Pediatr Res. 1982;16:65-68.
2. Zlotkin SH, Bryan MH, Anderson GH. Cysteine supplementation to cysteine-free intravenous feeding regimens in newborn infants. Am J Clin Nutr. 1981;34:914-923.
3. Shoveller AK, Brunton JA, House JD, Pencharz PB, Ball RO. Dietary cysteine reduces the methionine requirement by an equal proportion in both parenterally and enterally fed piglets. J Nutr. 2003;133:4215-4224.
4. Van Goudoever JB, Colen T, Wattimena JLD, et al. Immediate commencement of amino acid supplementation in preterm infants: effect on serum amino acid concentrations and protein kinetics on the first day of life. J Pediatr. 1995;127:458-465.
5. Pohlandt F. Cystine: a semi-essential amino acid in the newborn infant. Acta Paediatr Scand. 1974;63:801-804.
6. Stegink LD, Den Besten L. Synthesis of cysteine from methionine in normal adult subjects: effect of route of alimentation. Science. 1972;178:514-516.
7. Miller RG, Jahoor F, Jaksic T. Decreased cysteine and proline synthesis in parenterally fed, premature infants. J Pediatr Surg. 1995;30:953-958.
8. Moss RL, Haynes AL, Pastuszyn A, Glew RH. Methionine infusion reproduces liver injury of parenteral nutrition cholestasis. Pediatr Res. 1999;45:664-668.
9. Hardwick DF, Applegarth DA, Cockcroft DM, Ross PM, Cder RJ. Pathogenesis of methionine induced toxicity. Metabolism. 1970;19:381-391.
10. Shoveller AK, House JD, Brunton JA, Pencharz PB, Ball RO. The balance of dietary sulfur amino acids and the route of feeding affect plasma homocysteine concentrations in neonatal piglets. J Nutr. 2004;134:609-612.
11. Chen YF, Li PL, Zou AP. Effect of hyperhomocysteinemia on plasma or tissue adenosine levels and renal function. Circulation. 2002;106:1275-1281.
12. Corrales F, Ochoa P, Rivas C, Martin-Lomas M, Mato JM, Pajares MA. Inhibition of glutathione synthesis in the liver leads to S-adenosyl-L- methionine synthetase reduction. Hepatology. 1991;14:528-533.
13. Malloy MH, Rassin DK. Cysteine supplementation of total parenteral nutrition the effect in beagle pups. Pediatr Res. 1984;18:747-751.
14. Vina J, Vento M, Garcia-Sala F, et al. L-Cysteine and glutathione metabolism are impaired in premature infants due to cystathionase deficiency. Am J Clin Nutr. 1995;61:1067-1069.
15. Shahal Y, Bauminger ER, Zmora E, et al. Oxidative stress in newborn erythrocytes. Pediatr Res. 1991;29:119-122.
16. Mosharov E, Cranford MR, Banerjee R. The quantitatively important relationship between homocysteine metabolism and glutathione synthesis by the transsulfuration pathway and its regulation by redox changes. Biochemistry. 2000;39:13005-13011.
17. Heird WC. Amino acids in pediatric and neonatal nutrition. Curr Opin Clin Nutr Metab Care. 1998;1:73-78.
18. Laine L, Shulman RJ, Pitre D, Lifschitz CH, Adams J. Cysteine usage increases the need for acetate in neonates who receive total parenteral nutrition. Am J Clin Nutr. 1991;54:565-567.
19. Ventura P, Panini R, Pasini MC, Scarpetta G, Salvioli G. N-Acetyl-cysteine reduces homocysteine plasma levels after single intravenous administration by increasing thiols urinary excretion. Pharmacol Res. 1999;40:345-350.
20. Yip L, Dart RC, Hurlbut KM. Intravenous administration of oral N-acetylcysteine. Crit Care Med. 1998;26:40-43.
21. Ahola T, Fellman V, Laaksonen R, et al. Pharmacokinetics of intravenous N-acetyl-L-cysteine in pre-term newborn infants. Eur J Clin Pharmacol. 1999;55:645-650.
22. Wykes LJ, Ball RO, Pencharz PB. Development and validation of a total parenteral nutrition model in the neonatal piglet. J Nutr. 1993;123:1248-4259.
23. 14C]phenylalanine in neonatal piglets receiving total parenteral nutrition supplemented with tyrosine. Am J Clin Nutr. 1997;65:984-993.
24. House JD, Pencharz PB, Ball RO. Tyrosine kinetics and requirements during total parenteral nutrition in the neonatal piglet: the effect of glycyl-tyrosine supplementation. Pediatr Res. 1997; 41:575-583.
25. Wykes LJ, House JD, Ball RO, Pencharz PB. Aromatic amino acid metabolism of neonatal piglets receiving TPN: effect of tyrosine precursors. Am J Physiol. 1994;267:E672-E679.
26. Brunton JA, Bertolo RFP, Pencharz PB, Ball RO. Proline ameliorates arginine deficiency during enteral but not parenteral feeding in neonatal piglets. Am J Physiol. 1999;277:E223-E231.
27. th ed. Washington, DC: National Academy Press; 1998.
28. Bidlingmeyer BA, Cohen SA, Tarven TL. Rapid analysis of amino acids using pre-column derivatization. J Chromatogr. 1984;336:93-104.
29. House JD, Pencharz PB, Ball RO. Glutamine supplementation to TPN promotes extracellular fluid expansion in piglets. J Nutr. 1994;124:396-405.
30. Frank H, Thiel D. Determination of N-acetyl-L-cysteine in biological fluids. J Chromatogr. 1984;309:261-267.
31. Bertolo RFP, Chen CZL, Pencharz PB, Ball RO. Intestinal atrophy has a greater impact on nitrogen metabolism than liver by-pass in piglets fed identical diets via gastric, central venous or portal venous routes. J Nutr. 1999;129:1045-1052.
32. Neuhäuser M, Grötz KA, Wandira JA, Bässler KH, Langer K. Utilization of methionine and N-acetyl-L-cysteine during long-term parenteral nutrition in the growing rat. Metabolism. 1986; 35:869-873.
33. Baker DH, Han Y. Bioavailable level and source of cysteine determine protein quality of a commercial enteral product: adequacy of tryptophan but deficiency of cysteine for rats fed an enteral product prepared fresh or stored beyond shelf life. J Nutr. 1993;123:541-546.
34. Magnusson I, Ekman L, Wangdalh M, Wahren J. N-Acetyl-L-tyrosine and N-acetyl-L-cysteine as tyrosine and cysteine precursors during intravenous infusion in humans. Metabolism. 1989;38:957-961.
35. Van Goudoever JB, Sulkers EJ, Timmerman M, et al. Amino acid solutions for premature neonates during the first week of life: the role of N-acetyl-L-cysteine and N-acetyl-L-tyrosine. JPEN J Parenter Enteral Nutr. 1994;18:404-408.
36. Borgström L, Kågedal B, Paulsen O. Pharmacokinetics of N-acetyl-L-cysteine in man. Eur J Pharmacol. 1986;31:217-222.
37. Olsson B, Johansson M, Gabrielsson J, Bolme P. Pharmacokinetics and bioavailability of reduced and oxidized N-acetylcysteine. Eur J Clin Pharmacol. 1988;34:77-82.
38. Banks MF, Stipanuk MH. The utilization of N-acetyl-L-cysteine and 2-oxothiazolidine-4-carboxylate by rat hepatocytes is limited by their rate of uptake and conversion to cysteine. J Nutr. 1994;124:378-387.
39. Waterneid CJ, Timbrell JA. The biosynthesis of taurine from N-acetyl-L-cysteine and other precursors in vivo and in rat hepatocytes. Amino Acids. 1996;10:173-185.
40. Yamauchi A, Ueda N, Hanafusa S, Yamashita E, Kihara M, Naito S. Tissue distribution of and species differences in deacetylation of N-acetyl-L-cysteine and immunohistochemical localization of acylase I in the primate kidney. J Pharm Pharmacol. 2002;54:205-212.
41. Sjodin K, Nilsson E, Hallberg A, Tunek A. Metabolism of N-acetyl-L-cysteine: some structural requirements for the deacetylation and consequences for the oral bioavailability. Biochem Pharmacol. 1989;38:3981-3985.
42. Giardina T, Biagini A, Dalle Ore F, Ferre E, Reynier M, Puigserver A. The hog intestinal mucosa and acylase I: subcellular localization, isolation, kinetic studies and biological function. Biochimie. 1997;79:265-273.
43. Bertolo RFP, Pencharz PB, Ball RO. Organ and plasma amino acid concentrations are profoundly different in piglets fed identical diets via gastric, central venous or portal venous routes. J Nutr. 2000;130:1261-1266.
44. Baker DH, Bafundo KW, Boebel KP, Czarnecki GL, Halpin KM. Methionine peptides as potential food supplements: efficacy and susceptibility to Maillard Browning. J Nutr. 1984;114:292-297.