Acute resistance exercise does not change the hormonal response to sublingual androstenediol intake

European Journal of Applied Physiology

Volumn 97, Issue 4, 2006, Pages 404-412

  Brown, Gregory A ^a   McKenzie, Drew ^b  

^a UNIVERSITY OF NEBRASKA AT KEARNEY   (United States)

^b GEORGIA SOUTHERN UNIVERSITY   (United States)

Author keywords

Androstenediol; Androstenedione; Estradiol; Resistance exercise; Testosterone

Indexed keywords

ANDROSTENEDIOL; CYCLODIOL; ESTRADIOL; PLACEBO; TESTOSTERONE;

ADULT; ANDROGEN THERAPY; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; ESTRADIOL BLOOD LEVEL; EXERCISE; HORMONE ACTION; HORMONE RESPONSE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REST; SINGLE DRUG DOSE; STATISTICAL SIGNIFICANCE; TESTOSTERONE BLOOD LEVEL;

ADMINISTRATION, SUBLINGUAL; ADULT; ANABOLIC AGENTS; ANDROSTENEDIOL; ANDROSTENEDIONE; DOPING IN SPORTS; ENERGY INTAKE; ESTRADIOL; EXERCISE; HUMANS; MALE; TESTOSTERONE; TIME FACTORS;

EID: 33745443933     PISSN: 14396319     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00421-006-0194-9     Document Type: Article

References (44)

1. Summary of the second report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II) (1993). JAMA 269:3015-3023
2. Ballantyne CS, Phillips SM, MacDonald JR, Tarnopolsky MA, MacDougall JD (2000) The acute effects of androstenedione supplementation in healthy young males. Can J Appl Physiol 25:68-78
3. Berkovitz GD, Carter KM, Brown TR, Migeon CJ (1990) Testosterone lowers aromatase activity in cultured human genital skin fibroblasts. Mol Cell Endocrinol 69:187-197
4. Bhasin S, Storer TW, Berman N, Callegari C, Clevenger B, Phillips J, et al (1996) The effects of supraphysiologic doses of testosterone on muscle size and strength in normal men. N Engl J Med 335:1-7
5. Blaquier J, Forchielli E, Dorfman RI (1967) In vitro metabolism of androgens in whole human blood. Acta Endocrinol (Copenh) 55:697-704
6. Broeder CE, Quindry J, Brittingham K, Panton L, Thomson J, Appakondu S, et al (2000) The andro project: Physiological and hormonal influences of androstenedione supplementation in men 35 to 65 years old participating in a high-intensity resistance training program. Arch Intern Med 160:3093-3104
7. Brown GA, Martini ER, Roberts BS, Vukovich MD, King DS (2002) Acute hormonal response to sublingual androstenediol intake in young men. J Appl Physiol 92:142-146
8. Brown GA, Vukovich MD, Martini ER, Kohut ML, Franke WD, Jackson DA, et al (2000a) Endocrine responses to chronic androstenedione intake in 30- to 56-year-old men. J Clin Endocrinol Metab 85:4074-4080
9. Brown GA, Vukovich MD, Martini ER, Kohut ML, Franke WD, Jackson DA, et al (2001a) Effects of androstenedione-herbal supplementation on serum sex hormone concentrations in 30- to 59-year-old men. Int J Vitam Nutr Res 71:293-301
10. Brown GA, Vukovich MD, Martini ER, Kohut ML, Franke WD, Jackson DA, et al (2001b) Endocrine and lipid responses to chronic androstenediol-herbal supplementation in 30 to 58-year-old men. J Am Coll Nutr 20:520-528
11. Brown GA, Vukovich MD, Reifenrath TA, Uhl NL, Parsons KA, Sharp RL, et al (2000b) Effects of anabolic precursors on serum testosterone concentrations and adaptations to resistance training in young men. Int J Sport Nutr Exerc Metab 10:340-359
12. Brown GA, Vukovich MD, Sharp RL, Reifenrath TA, Parsons KA, King DS (1999) Effect of oral DHEA on serum testosterone and adaptations to resistance training in young men. J Appl Physiol 87:2274-2283
13. Brown WJ, Basil MD, Bocarnea MC (2003) The influence of famous athletes on health beliefs and practices: Mark McGwire, child abuse prevention, and androstenedione. J Health Commun 8:41-57
14. Cadoux-Hudson TA, Few JD, Imms FJ (1985) The effect of exercise on the production and clearance of testosterone in well trained young men. Eur J Appl Physiol Occup Physiol 54:321-325
15. Delp MD (1999) Control of skeletal muscle perfusion at the onset of dynamic exercise. Med Sci Sports Exerc 31:1011-1018
16. Earnest CP, Olson MA, Broeder CE, Breuel KF, Beckham SG (2000) In vivo 4-androstene-3,17-dione and 4-androstene-3 beta,17 beta-diol supplementation in young men. Eur J Appl Physiol 81:229-232
17. Ferrando AA, Sheffield-Moore M, Yeckel CW, Gilkison C, Jiang J, Achacosa A, et al (2002) Testosterone administration to older men improves muscle function: Molecular and physiological mechanisms. Am J Physiol Endocrinol Metab 282:E601-E607
18. Frenkl R, Szeberenyi S (1976) Enzyme inducing effect of muscular exertion in the rat. Acta Med Acad Sci Hung 33:95-100
19. Fyssas I, Syrigos KN, Konstandoulakis MM, Papadopoulos S, Milingos N, Anapliotou M, et al (1997) Sex hormone levels in the serum of patients with pancreatic adenocarcinoma. Horm Metab Res 29:115-118
20. Hoffman JR, Maresh CM, Armstrong LE, Gabaree CL, Bergeron MF, Kenefick RW, et al (1994) Effects of hydration state on plasma testosterone, cortisol and catecholamine concentrations before and during mild exercise at elevated temperature. Eur J Appl Physiol Occup Physiol 69:294-300
21. Horton R, Hsieh P, Barberia J, Pages L, Cosgrove M (1975) Altered blood androgens in elderly men with prostate hyperplasia. J Clin Endocrinol Metab 41:793-796
22. Horton R, Tait JF (1966) Androstenedione production and interconversion rates measured in peripheral blood and studies on the possible site of its conversion to testosterone. J Clin Invest 45:301-313
23. Jasuja R, Ramaraj P, Mac RP, Singh AB, Storer TW, Artaza J, et al (2005) Delta-4-androstene-3,17-dione binds androgen receptor, promotes myogenesis in vitro, and increases serum testosterone levels, fat-free mass, and muscle strength in hypogonadal men. J Clin Endocrinol Metab 90:855-863
24. Kanayama G, Gruber AJ, Pope HG Jr, Borowiecki JJ, Hudson JI (2001) Over-the-counter drug use in gymnasiums: An underrecognized substance abuse problem? Psychother Psychosom 70:137-140
25. King DS, Sharp RL, Vukovich MD, Brown GA, Reifenrath TA, Uhl NL, et al (1999) Effect of oral androstenedione on serum testosterone and adaptations to resistance training in young men: A randomized controlled trial. JAMA 281:2020-2028
26. Kley HK, Deselaers T, Peerenboom H, Kruskemper HL (1980) Enhanced conversion of androstenedione to estrogens in obese males. J Clin Endocrinol Metab 51:1128-1132
27. Kraemer WJ (1988) Endocrine responses to resistance exercise. Med Sci Sports Exerc 20:S152-S157
28. Kraemer WJ, Marchitelli L, Gordon SE, Harman E, Dziados JE, Mello R, et al (1990) Hormonal and growth factor responses to heavy resistance exercise protocols. J Appl Physiol 69:1442-1450
29. Kraemer WJ, Adams K, Cafarelli E, Dudley GA, Dooly C, Feigenbaum MS, et al (2002) American College of Sports Medicine position stand. Progression models in resistance training for healthy adults. Med Sci Sports Exerc 34:364-380
30. Labrie F, Belanger A, Cusan L, Candas B (1997) Physiological changes in dehydroepiandrosterone are not reflected by serum levels of active androgens and estrogens but of their metabolites: Intracrinology. J Clin Endocrinol Metab 82:2403-2409
31. Leder BZ, Longcope C, Catlin DH, Ahrens B, Schoenfeld DA, Finkelstein JS (2000) Oral androstenedione administration and serum testosterone concentrations in young men. JAMA 283:779-782
32. Longcope C, Kato T, Horton R (1969) Conversion of blood androgens to estrogens in normal adult men and women. J Clin Invest 48:2191-2201
33. Longcope C, Pratt JH, Schneider SH, Fineberg SE (1978) Aromatization of androgens by muscle and adipose tissue in vivo. J Clin Endocrinol Metab 46:146-152
34. Lundbergh P, Strandell T (1973) The effect of physical exercise on the wedged and free hepatic venous pressure in normal men. Acta Med Scand 194:211-214
35. Lupo C, Baldi L, Bonifazi M, Lodi L, Martelli G, Viti A, et al (1985) Androgen levels following a football match. Eur J Appl Physiol Occup Physiol 54:494-496
36. Mace AE (1974) Sample-size determination. Robert E. Krieger Publishing Company, Huntington, NY, pp 77-80
37. Ploutz-Snyder LL, Convertino VA, Dudley GA (1995) Resistance exercise-induced fluid shifts: Change in active muscle size and plasma volume. Am J Physiol 269:R536-R543
38. Rasmussen BB, Volpi E, Gore DC, Wolfe RR (2000) Androstenedione does not stimulate muscle protein anabolism in young healthy men. J Clin Endocrinol Metab 85:55-59
39. Salehian B, Wang C, Alexander G, Davidson T, McDonald V, Berman N, et al (1995) Pharmacokinetics, bioefficacy, and safety of sublingual testosterone cyclodextrin in hypogonadal men: Comparison to testosterone enanthate - a clinical research center study. J Clin Endocrinol Metab 80:3567-3575
40. Stuenkel CA, Dudley RE, Yen SS (1991) Sublingual administration of testosterone-hydroxypropyl-beta- cyclodextrin inclusion complex simulates episodic androgen release in hypogonadal men. J Clin Endocrinol Metab 72:1054-1059
41. Tremblay MS, Copeland JL, Van Helder W (2004) Effect of training status and exercise mode on endogenous steroid hormones in men. J Appl Physiol 96:531-539
42. Urban RJ, Bodenburg YH, Gilkison C, Foxworth J, Coggan AR, Wolfe RR, et al (1995) Testosterone administration to elderly men increases skeletal muscle strength and protein synthesis. Am J Physiol 269:E820-E826
43. Villalpando S, Mondragon L, Barron C, Perez-Pasten E, Castaneda G, Alonso-Uriarte R, et al (1992) Role of testosterone and dihydrotestosterone in spontaneous gynecomastia of adolescents. Arch Androl 28:171-176
44. Volek JS, Gomez AL, Love DM, Avery NG, Sharman MJ, Kraemer WJ (2001) Effects of a high-fat diet on postabsorptive and postprandial testosterone responses to a fat-rich meal. Metabolism 50:1351-1355