Endocrine and Lipid Responses to Chronic Androstenediol-Herbal Supplementation in 30 to 58 Year Old Men

Journal of the American College of Nutrition

Volumn 20, Issue 5, 2001, Pages 520-528

  Brown, Gregory A ^a   Martini, Emily R ^a   Kohut, Marian L ^a   Franke, Warren D ^a   Jackson, David A ^a   King, Douglas S ^a   Vukovich, Matthew D ^b  

^a IOWA STATE UNIVERSITY   (United States)

^b SOUTH DAKOTA STATE UNIVERSITY   (United States)

Author keywords

Androstenediol; Chrysin; Gamma linolenic acid; Indole 3 carbinol; Saw palmetto; Tribulus terrestris

Indexed keywords

3 INDOLEMETHANOL; ANDROSTANOLONE; ANDROSTENEDIOL; ANDROSTENEDIONE; CHRYSIN; ESTRADIOL; GAMMA LINOLENIC ACID; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPID; PROSTATE SPECIFIC ANTIGEN; TESTOSTERONE;

ADULT; AGE; AGED; ANDROGEN BLOOD LEVEL; ARTICLE; CLINICAL TRIAL; CONCENTRATION RESPONSE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DRUG EFFECT; ESTRADIOL BLOOD LEVEL; HERBAL MEDICINE; HUMAN; LIPID BLOOD LEVEL; LIPID METABOLISM; MALE; NORMAL HUMAN; RANDOMIZED CONTROLLED TRIAL; TESTOSTERONE BLOOD LEVEL; TRIBULUS TERRESTRIS;

ADMINISTRATION, ORAL; ADULT; AGE FACTORS; ANABOLIC AGENTS; ANDROSTENEDIOL; ANDROSTENEDIONE; CHOLESTEROL, HDL; CHOLESTEROL, LDL; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; ESTRADIOL; HUMANS; MALE; MIDDLE AGED; PLACEBOS; PROSTATE-SPECIFIC ANTIGEN; TESTOSTERONE; TIME FACTORS;

EID: 0034796819     PISSN: 07315724     EISSN: 15411087     Source Type: Journal    
DOI: 10.1080/07315724.2001.10719061     Document Type: Article

References (27)

1. Inaba M, Nakao T: Conversion of 4-androstenediol and 5-androstenediol to testosterone, and conversion of dehydroepiandrosterone to 4-androstenediol by rat testis in vitro. Endocrinol Jpn 13: 160-172, 1966.
2. Blaquier J, Forchielli E, Dorfman RI: In vitro metabolism of androgens in whole human blood. Acta Endocrinol (Copenh) 55: 697-704, 1967.
3. Earnest CP, Olson MA, Broeder CE, Breuel KF, Beckham SG: In vivo 4-androstene-3,17-dione and 4-androstene-3 beta, 17 betadiol supplementation in young men. Eur J Appl Physiol 81: 229-232, 2000.
4. Broeder CE, Quindry J, Brittingham K, Panton L, Thomson J, Appakondu S, Breuel K, Byrd R, Douglas J, Earnest C, Mitchell C, Olson M, Roy T, Yarlagadda C: The andro project: physiological and hormonal influences of androstenedione supplementation in men 35 to 65 years old participating in a high-intensity resistance training program. Arch Intern Med 160: 3093-3104, 2000.
5. Sultan C, Terraza A, Devillier C, Carilla E, Briley M, Loire C, Descomps B: Inhibition of androgen metabolism and binding by a liposterolic extract of “Serenoa repens B” in human foreskin fibroblasts. J Steroid Biochem 20: 515-519, 1984.
6. Liang T, Liao S: Inhibition of steroid 5 alpha-reductase by specific aliphatic unsaturated fatty acids. Biochem J 285 (Pt 2): 557-562, 1992.
7. Kellis JT, Vickery LE: Inhibition of human estrogen synthetase (aromatase) by flavones. Science 225: 1032-1034, 9-7-1984.
8. Michnovicz JJ, Bradlow HL: Altered estrogen metabolism and excretion in humans following consumption of indole-3-carbinol. Nutr Cancer 16: 59-66, 1991.
9. Brown GA, Vukovich MD, Martini ER, Kohut ML, Franke WD, Jackson DA, King DS: Endocrine responses to chronic androstenedione intake in 30-to 56-year-old men. J Clin Endocrinol Metab 85: 4074-4080, 2000.
10. Brown GA, Vukovich MD, Martini ER, Kohut ML, Franke WD, King DS: Effects of androstenedione-herbal supplementation on serum sex hormone concentrations in 30-59 year old men. Int J Vit Nutr Res, in press, 2001.
11. King DS, Sharp RL, Vukovich MD, Brown GA, Reifenrath TA, Uhl NL, Parsons KA: Effect of oral androstenedione on serum testosterone and adaptations to resistance training in young men: a randomized controlled trial. JAMA 281: 2020-2028, 1999.
12. Brown GA, Vukovich MD, Reifenrath TA, Uhl NL, Parsons KA, Sharp RL, King DS: Effects of anabolic precursors on serum testosterone concentrations and adaptations to resistance training in young men. Int J Sport Nutr Exerc Metab 10: 340-359, 2000.
13. Leder BZ, Longcope C, Catlin DH, Ahrens B, Schoenfeld DA, Finkelstein JS: Oral androstenedione administration and serum testosterone concentrations in young men. JAMA 283: 779-782, 2000.
14. Brown GA, Martini ER, Roberts BS, Vukovich MD, King DS: Acute hormonal response to sublingual androstenediol intake in young men. J Appl Physiol, in press, 2001.
15. Mean F, Pellaton M, Magrini G: Study on the binding of dihydrotestosterone, testosterone and oestradiol with sex hormone binding globulin. Clin Chim Acta 80: 171-180, 1977.
16. Winters SJ, Kelley DE, Goodpaster B: The analog free testosterone assay: are the results in men clinically useful? Clin Chem 44: 2178-2182, 1998.
17. Kratzsch J, Keller E, Hoepffner W, Muller G, Reich A, Meyer K, Kiess W: The DSL analog free testosterone assay: serum levels are not related to sex hormone-binding globulin in normative data throughout childhood and adolescence. Clin Lab 47: 73-77, 2001.
18. Ooi DS, Donnelly JG: More on the analog free-testosterone assay. Clin Chem 45: 714-716, 1999.
19. Bhasin S, Storer TW, Berman N, Callegari C, Clevenger B, Phillips J, Bunnell TJ, Tricker R, Shirazi A, Casaburi R: The effects of supraphysiologic doses of testosterone on muscle size and strength in normal men. N Engl J Med 335: 1-7, 1996.
20. Urban RJ, Bodenburg YH, Gilkison C, Foxworth J, Coggan AR, Wolfe RR, Ferrando A: Testosterone administration to elderly men increases skeletal muscle strength and protein synthesis. Am J Physiol 269: E820-E826, 1995.
21. Ferrando AA, Tipton KD, Doyle D, Phillips SM, Cortiella J, Wolfe RR: Testosterone injection stimulates net protein synthesis but not tissue amino acid transport. Am J Physiol 275: E864-E871, 1998.
22. Longcope C, Fineberg SE: Production and metabolism of dihydrotestosterone in peripheral tissues. J Steroid Biochem 23: 415-419, 1985.
23. Winter ML, Bosland MC, Wade DR, Falvo RE, Nagamani M, Liehr JG: Induction of benign prostatic hyperplasia in intact dogs by near-physiological levels of 5 alpha-dihydrotestosterone and 17 beta-estradiol. Prostate 26: 325-333, 1995.
24. Hinman F: Screening for prostatic carcinoma. J Urol 145: 126-129, 1991.
25. Fernandez-del Castillo C, Robles-Diaz G, Diaz-Sanchez V, Altamirano A: Pancreatic cancer and androgen metabolism: high androstenedione and low testosterone serum levels. Pancreas 5: 515-518, 1990.
26. Phillips GB, Pinkernell BH, Jing TY: The association of hyperestrogenemia with coronary thrombosis in men. Arterioscler Thromb Vasc Biol 16: 1383-1387, 1996.
27. Summary of the second report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II). JAMA 269: 3015-3023, 1993.