Mechanisms of sterol regulatory element-binding protein-2 (SREBP-2) regulation of human prostasin gene expression

Biochemical and Biophysical Research Communications

Volumn 346, Issue 4, 2006, Pages 1245-1253

  Chen, Mengqian ^a   Chen, Li Mei ^a   Chai, Karl X ^a  

^a UNIVERSITY OF CENTRAL FLORIDA   (United States)

Author keywords

Electrophoretic mobility shift assay (EMSA); Glycosylphosphatidylinositol; Promoter activity assay; Serine protease

Indexed keywords

PROSTASIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; TRANSCRIPTION FACTOR;

ARTICLE; BINDING SITE; CELL STRAIN HEK293; DNA FLANKING REGION; EMBRYO; GEL MOBILITY SHIFT ASSAY; GENE CONSTRUCT; GENE CONTROL; GENE DELETION; GENE EXPRESSION; GENETIC ANALYSIS; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MUTAGENESIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REPORTER GENE; TRANSCRIPTION INITIATION; UPREGULATION;

5' FLANKING REGION; BINDING SITES; CELLS, CULTURED; GENE EXPRESSION; GENE EXPRESSION REGULATION; HUMANS; PROMOTER REGIONS (GENETICS); SERINE ENDOPEPTIDASES; SERUM RESPONSE ELEMENT; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; TRANSCRIPTION FACTORS;

EID: 33745388678     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.06.049     Document Type: Article

References (27)

1. Yu J.X., Chao L., and Chao J. Prostasin is a novel human serine proteinase from seminal fluid. Purification, tissue distribution, and localization in prostate gland. J. Biol. Chem. 269 (1994) 18843-18848
2. Vallet V., Chraibi A., Gaeggeler H.P., Horisberger J.D., and Rossier B.C. An epithelial serine protease activates the amiloride-sensitive sodium channel. Nature 389 (1997) 607-610
3. Yu J.X., Chao L., and Chao J. Molecular cloning, tissue-specific expression, and cellular localization of human prostasin mRNA. J. Biol. Chem. 270 (1995) 13483-13489
4. Fan B., Wu T.D., Li W., and Kirchhofer D. Identification of hepatocyte growth factor activator inhibitor-1B as a potential physiological inhibitor of prostasin. J. Biol. Chem. 280 (2005) 34513-34520
5. Chen L.M., Skinner M.L., Kauffman S.W., Chao J., Chao L., Thaler C.D., and Chai K.X. Prostasin is a glycosylphosphatidylinositol-anchored active serine protease. J. Biol. Chem. 276 (2001) 21434-21442
6. Mok S.C., Chao J., Skates S., Wong K., Yiu G.K., Muto M.G., Berkowitz R.S., and Cramer D.W. Prostasin, a potential serum marker for ovarian cancer: identification through microarray technology. J. Natl. Cancer Inst. 93 (2001) 1458-1464
7. Chen L.M., Hodge G.B., Guarda L.A., Welch J.L., Greenberg N.M., and Chai K.X. Down-regulation of prostasin serine protease: a potential invasion suppressor in prostate cancer. Prostate 48 (2001) 93-103
8. Chen L.M., and Chai K.X. Prostasin serine protease inhibits breast cancer invasiveness and is transcriptionally regulated by promoter DNA methylation. Int. J. Cancer 97 (2002) 323-329
9. Vuagniaux G., Vallet V., Jaeger N.F., Pfister C., Bens M., Farman N., Courtois-Coutry N., Vandewalle A., Rossier B.C., and Hummler E. Activation of the amiloride-sensitive epithelial sodium channel by the serine protease mCAP1 expressed in a mouse cortical collecting duct cell line. J. Am. Soc. Nephrol. 11 (2000) 828-834
10. Donaldson S.H., Hirsh A., Li D.C., Holloway G., Chao J., Boucher R.C., and Gabriel S.E. Regulation of the epithelial sodium channel by serine proteases in human airways. J. Biol. Chem. 277 (2002) 8338-8345
11. Tong Z., Illek B., Bhagwandin V.J., Verghese G.M., and Caughey G.H. Prostasin, a membrane-anchored serine peptidase, regulates sodium currents in JME/CF15 cells, a cystic fibrosis airway epithelial cell line. Am. J. Physiol. Lung Cell. Mol. Physiol. 287 (2004) L928-L935
12. Leyvraz C., Charles R.P., Rubera I., Guitard M., Rotman S., Breiden B., Sandhoff K., and Hummler E. The epidermal barrier function is dependent on the serine protease CAP1/Prss8. J. Cell Biol. 170 (2005) 487-496
13. Takahashi S., Suzuki S., Inaguma S., Ikeda Y., Cho Y.M., Hayashi N., Inoue T., Sugimura Y., Nishiyama N., Fujita T., Chao J., Ushijima T., and Shirai T. Down-regulated expression of prostasin in high-grade or hormone-refractory human prostate, cancers. Prostate 54 (2003) 187-193
14. Chen M., Chen L.M., and Chai K.X. Androgen regulation of prostasin gene expression is mediated by sterol-regulatory element-binding proteins and SLUG. Prostate 66 (2006) 911-920
15. Horton J.D. Sterol regulatory element-binding proteins: transcriptional activators of lipid synthesis. Biochem. Soc. Trans. 30 (2002) 1091-1095
16. Rawson R.B. The SREBP pathway-insights from insigs and insects. Nat. Rev. Mol. Cell Biol. 4 (2003) 631-640
17. Horton J.D., Goldstein J.L., and Brown M.S. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J. Clin. Invest. 109 (2002) 1125-1131
18. Osborne T.F. Sterol regulatory element-binding proteins (SREBPs): key regulators of nutritional homeostasis and insulin action. J. Biol. Chem. 275 (2000) 32379-32382
19. Shimano H. Sterol regulatory element-binding proteins (SREBPs): transcriptional regulators of lipid synthetic genes. Prog. Lipid Res. 40 (2001) 439-452
20. Horton J.D., Shah N.A., Warrington J.A., Anderson N.N., Park S.W., Brown M.S., and Goldstein J.L. Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes. Proc. Natl. Acad. Sci. USA 100 (2003) 12027-12032
21. Yu J.X., Chao L., Ward D.C., and Chao J. Structure and chromosomal localization of the human prostasin (PRSS8) gene. Genomics 32 (1996) 334-340
22. Briggs M.R., Yokoyama C., Wang X., Brown M.S., and Goldstein J.L. Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. I. Identification of the protein and delineation of its target nucleotide sequence. J. Biol. Chem. 268 (1993) 14490-14496
23. Chen L.M., Zhang X., and Chai K.X. Regulation of prostasin expression and function in the prostate. Prostate 59 (2004) 1-12
24. Blanco M.J., Moreno-Bueno G., Sarrio D., Locascio A., Cano A., Palacios J., and Nieto M.A. Correlation of Snail expression with histological grade and lymph node status in breast carcinomas. Oncogene 21 (2002) 3241-3246
25. Hajra K.M., Chen D.Y., and Fearon E.R. The SLUG zinc-finger protein represses E-cadherin in breast cancer. Cancer Res. 62 (2002) 1613-1618
26. Hemavathy K., Ashraf S.I., and Ip Y.T. Snail/slug family of repressors: slowly going into the fast lane of development and cancer. Gene 257 (2000) 1-12
27. Chen Y., and Hughes-Fulford M. Human prostate cancer cells lack feedback regulation of low-density lipoprotein receptor and its regulator, SREBP2. Int. J. Cancer 91 (2001) 41-45