Evaluating dynamic contrast-enhanced and photoacoustic CT to assess intra-tumor heterogeneity in xenograft mouse models

Progress in Biomedical Optics and Imaging - Proceedings of SPIE

Volumn 6143 I, Issue , 2006, Pages

  Stantz, Keith M ^a,b   Liu, Bo ^a   Cao, Minsong ^a   Reinecke, Dan ^c   Dzemidzic, Mario ^b   Liang, Yun ^b   Kruger, Robert ^c  

^a PURDUE UNIVERSITY   (United States)

^b INDIANA UNIVERSITY   (United States)

^c OptoSonics Inc   (United States)

Author keywords

Breast cancer; Dynamic contrast enhanced CT; Hemoglobin; Ovarian cancer; Oxygen saturation; Photoacoustic spectroscopy

Indexed keywords

BREAST CANCER; DYNAMIC CONTRAST-ENHANCED CT; OVARIAN CANCER; OXYGEN SATURATION;

BIODIVERSITY; BLOOD; HEMOGLOBIN; IMMUNOLOGY; PHOTOACOUSTIC SPECTROSCOPY; PHYSIOLOGY; TUMORS;

COMPUTERIZED TOMOGRAPHY;

EID: 33745376612     PISSN: 16057422     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1117/12.654056     Document Type: Conference Paper

References (32)

1. Jain RK, "Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy", Science 307:58, 2005.
2. Verschraegen C, Vinh-Hung V, Cserni G, et al., "Modeling the effect of tumor size in early breast cancer", Annals of Surgery 241(2):309-318, 2005.
3. Vaupel P, Harrison L, "Tumor Hypoxia: Causative Factors, Compensatory Mechanisms, and Cellular Response", The Oncologist 9(Suppl 5):4-9, 2004.
4. Menon C, Fraker DL, "Tumor oxygenation status as a prognostic marker", Cancer Letters 221:225-235, 2005.
5. Kunz M, Ibrahim SM, "Molecular responses to hypoxia in tumor cells", Molecular Cancer 2:23-35, 2003.
6. Winkler F, et al., "Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: Role of oxygenation, angiopoietin-1, and matrix metal loproteinases", Cancer Cell 6:553-563, 2004.
7. Wildiers H, Guetens G, De Boeck G, et al., "Effect of antivascular endothelial growth factor treatment on the intratumoral uptake of CPT-II", British Journal of Cancer 88(12): 1979-1986, 2003.
8. Pietras K, Stumm M, Hubert M, et al., "STI571 enhances the therapeutic index of epothilone B by a tumor-selective increase of drug uptake", Clinical Cancer Reearch 9(10):3779-3787, 2003.
9. Hurwitz H, Fehrenbacher L, Novotny W, et al., "Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer", New England Journal of Medicine 350(23):2325-2342, 2004.
10. Teicher BA, Holder SA, et al., "Classification of antineoplastic treatments by their differential toxicity toward putative oxygenated and hypoxic tumor subpopulations in viv in the FSaIIC murine fibrosarcoma", Cancer Research 50:3339-3344, 1990.
11. Jain RK, "Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy", Nature Medicine 7(9):987-989, 2001.
12. Stantz KM, Liang Y, Li X, Kao C, Steinmetz R, "Imaging the Progression of Intra-tumor Heterogeneity in Prostate and Ovarian Xenografts using Dynamic Contrast-Enhanced CT", Proc. IEEE EMBC, 2005.
13. Graff BA, Benjaminsen IC, Melas EA, et al., "Changes in intratumor heterogeneity in blood perfusion in intradermal human melanoma xenografts during tumor growth assessed by DCE-MRI", Magnetic Resonance Imaging 23(9):961-966, 2005.
14. Munn LL, "Aberrant vascular architecture in rumors and its importance in drug-based therapies", Drug Discovery Today 8(9):396-403, 2003.
15. Jain RK, "Molecular regulation of vessel maturation", Nature Medicine 9(6):685-693, 2003.
16. Littlewood TJ, "The impact of hemoglobin levels on treatment outcomes in patients with cancer", Seminars in Oncology 28(suppl 8):49-53, 2001.
17. Harrison LB, Chadha M, et al., "Impact of tumor hypoxia and anemia on radiation therapy outcomes", Oncologist 7:492-508, 2002.
18. Brix G, Bahner ML, Hoffmann UJ, et al., "Regional blood flow capillary permeability, and compartmental volumes: Measurement with dynamic CT - Initial experience", Radiology 210 (1): 269-276, 1999.
19. Kelman GR, J Appl Physiol. 21(4): 1375-1376, 1966.
20. Severinghaus, JW, J Appl. Physiol.: Respir. Environ. Exercise Physiol. 46(3): 599-602, 1979.
21. D.A. Nelson, et. al., "Hypoxia and defective apoptosis drive genomic instability and tumorigenesis", Genes Dev 18:2095-2107, (2004).
22. Vaupel P, Hockel M, "Tumor oxygenation and its relevance to tumor physiology and treatment", Adv. Exp Med. Biol. 510:45-49, 2003.
23. Howe FA, Robinson SP, et al., "Issues in GRE & SE magnetic resonance imaging to probe tumor oxygenation", Oxygen Transport to Tissue XXIV Advances in Experimental Medicine and Biology 530:441-448, 2003.
24. Kruger RA, Kiser Jr WL, Reinecke DR, Kruger GA, Miller KD, "Thermoacoustic optical molecular imaging of small animals", Molecular Imaging 2(2): 113-123, 2003.
25. Kruger RA, Kiser Jr WL, Reinecke DR, Kruger GA. "Thermoacoustic computed tomography using a conventional linear transducer array", Medical Physics 30(5):856-860, 2003.
26. Kim JG, Zhao DW, et al., "Interplay of tumor vascular oxygenation and tumor pO(2) observed using near-infrared spectroscopy, an oxygen needle electrode, and F-19 MR pO(2) mapping", Journal of Biomedical Optics 8(1):53-62, 2003.
27. Laufer J, Elwell C, et al., "In vitro measurements of absolute blood oxygen saturation using pulsed near-infrared photoacoustic spectroscopy: accuracy and resolution", Phys. Med. Biol. 50:4409-4428, 2005.
28. Stantz KM, Liu Bo, et al., "Photoacoustic Spectroscopic Imaging of Intra-Tumor Heterogeneity and Molecular Identification", Proc. SPIE BIOS, 2006.
29. Heffer E, Pera V, et al., "Near-infrared imaging of the human breast: complementing hemoglobin concentration maps with oxygenation images", J Biomedical Optics 9(6):1152-1160, 2004.
30. Miller KD, Miller M, et al., "A physiologic imaging pilot study of breast cancer treated with AZD2171", Clinical Cancer Research 12(1):281-8, 2006.
31. Gossmann A, Helbich TH, et al., "Magnetic resonance imaging in an experimental model of human ovarian cancer demonstrating altered micro vascular permeability after inhibition of vascular endothelial growth factor", Am J Obstet Gynecol 183(4):956-963, 2000.
32. Stantz KM, Liang Y, et al., "Kinematic Modeling and Its Implication in Longitudinal Chemotherapy Study of Tumor Physiology: Ovarian Xenograft Mouse Model and Contrast-Enhanced Dynamic CT," Proc. SPIE Vol. 5369:769-779, 2004.