Predicting cancer risk from vinyl chloride exposure with a physiologically based pharmacokinetic model

Toxicology and Applied Pharmacology

Volumn 137, Issue 2, 1996, Pages 253-267

  Reitz, Richard H ^a   Gargas, Michael L ^b   Andersen, Melvin E ^c   Provan, W M ^d   Green, Trevor L ^d  

^a RHR Consulting Services   (United States)

^b McLaren Hart Environ Services   (United States)

^c ICF Kaiser Engineers Inc   (United States)

^d ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

VINYL CHLORIDE;

ANGIOSARCOMA; ANIMAL MODEL; ARTICLE; CANCER RISK; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; HUMAN; LIVER CANCER; MALE; METABOLITE; MODEL; MOUSE; NONHUMAN; PHARMACOKINETICS; PREDICTION; RAT; XENOBIOTIC METABOLISM;

EID: 0029875099     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1996.0079     Document Type: Article

References (38)

1. Andersen, M. E., Gargas, M. L., and Ramsey, J. C. (1984). Inhalation pharmacokinetics: Evaluating system extraction, total in vivo metabolism, and the time course of enzyme induction for inhaled styrene in rats based on steady-state blood:air concentration ratios. Toxicol. Appl. Pharmacol. 73, 176-187.
2. Andersen, M. E., Clewell, H. J., Gargas, M. L., Smith, F. A., and Reitz, R. H. (1987). Physiologically-based pharmacokinetics and the risk assessment process for methylene chloride. Toxicol. Appl. Pharmacol. 87, 185-205.
3. Andersen, M. E., Clewell, H. J., Gargas, M. L., MacNaughton, M. G., Reitz, R. H., Nolan, R. J., and McKenna, M. J. (1991). Physiologically based pharmacokinetic modeling with dichloromethane, its metabolite, Carbon Monoxide, and blood Carboxyhemoglobin in Rats and Humans. Toxicol. Appl. Pharmacol. 108, 14-27.
4. 1 mice in vivo. Toxicol. Appl. Pharmacol. 128, 158-165.
5. Baretta, E. D., Stewart, R. D., and Mutchler, J. E. (1969). Monitoring exposures to vinyl chloride vapor: Breath analysis and continuous air sampling. Am. Ind. Hyg. Assoc. J. 30, 537-544.
6. Buchter, A., Bolt, H. M., Filser, J., Goergens, H. W., Laib, R. J., and Bolt, W. (1978). Pharmakokinetik and karzinogenese von vinylchlorid abreitmedizinische risikobeurteilung. Verh. Dtsch. Ges. Arbeitsmed. 18, 111-124.
7. Corley, R. A., Mendrala, A. M., Smith, F. A., Staats, D. A., Gargas, M. L., Conolly, R. B., Andersen, M. E., and Reitz, R. H. (1990). Development of a physiologically based pharmacokinetic based model for chloroform. Toxicol. Appl. Pharmacol. 103, 512-527.
8. Creech, J. L., and Johnson, M. N. (1974). Angiocarcoma of the liver in the manufacture of PVC. J. Occup. Med. 16, 150-151.
9. Drew, R. T., Boorman, G. A., Haseman, J. K., McConnell, E. E., Busey, W. M., and Moore, J. A. (1983). The effect of age and exposure duration on cancer induction by a known carcinogen in rats, mice, and hamsters. Toxicol. Appl. Pharmacol. 68, 120-130.
10. ECETOC (1988). The Mutagenicity and Carcinogenicity of Vinyl Chloride: A Historical Review and Assessment. Technical Report No. 31, ISSN 0773-8072-31, Brussels, Belgium.
11. Gargas, M. L., Andersen, M. E., and Clewell, H. J., III. (1986). A physiologically-based simulation approach for determining metabolic constants from gas uptake data. Toxicol. Appl. Pharmacol. 86, 341-352.
12. Gargas, M. L., Burgess, R. J., Voisard, D. E., Cason, G. H., and Andersen, M. E. (1989). Partition coefficients of low-molecular-weight volatile chemicals in various liquids and tissues. Toxicol. Appl. Pharmacol. 98, 87-99.
13. Gargas, M. L., Clewell, H. J., III, and Andersen, M. E. (1990). Gas uptake inhalation techniques and the rates of metabolism of chloromethane, chloroethanes, and chloroethylenes in the rat. Inhalation Toxicol. 2, 295-319.
14. Gehring, P. J., Watanabe, P. G., and Park, C. N. (1978). Resolution of dose-response toxicity data for chemicals requiring metabolic activation. Toxicol. Appl. Pharmacool. 44, 581-591.
15. Guengerich, F. P., Kim, D. H., and Iwasaki, M. (1991). Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects. Chem. Res. Toxicol. 4, 168-179.
16. 36Cl)-labeled vinyl chloride in vivo and in vitro. Biochem. Pharmacol. 28, 589-596.
17. Health Effects Assessment Summary Tables (HEAST) (1995). United States Environmental Protection Agency, Office of Solid Waste and Emergency Response, 9200.6-303 (95-1), EPA/540 R-95/036, PB95-921199, May 1995.
18. Howe, R. B. (1983). GLOBAL83: An Experimental Program Developed for the U.S. Environmental Protection Agency as an update to GLOBAL82.
19. Howe, R. B., and Crump, K. S. (1982). GLOBAL83: A Computer Program to Extrapolate Quantal Animal Toxicity Data to Low Doses (May 1982). OSHA Contract No. 41USC252C3.
20. International Commission on Radiation Protection (1975). Report of the Task Group on Reference Man (W. S. Snyder et al., Eds), ICRP Publication 23, Pergamon Press, New York.
21. 14C-VC and transformation to protein alkylating metabolites in vitro. Toxicol. Appl. Pharmacool. 37, 461.
22. Lee, C. C., Bhandari, J. C., Winston, J. M., Jouse, W. B., Dixon, R. L., and Woods, J. S. (1978). Carcinogenicity of vinyl chloride and vinylidene chloride. J. Toxicol. Environ. Health 4, 15-26.
23. Maltoni, C. (1974). Vinyl Chloride Carcinogenicity: An Experimental Model for Carcinogenesis Studies. Monograph from the Institute of Oncology and Tumour Center, Bologna, Italy 40138.
24. Maltoni, C., Lefemine, C., Chieco, P., and Carrettu, D. (1974). Vinyl chloride carcinogenesis: Current results and perspectives. Med. Lav. 65, 421.
25. Müller, G., Spassovski, M., and Henschler, D. (1974). Metabolism of trichloroethylene in man. II. Pharmacokinetics of metabolites. Arch. Toxicol. 32, 283-295.
26. Nakajima, T., Wang, R. S., Murayama, N., and Sato, A. (1990). Three forms of trichloroethylene-metabolizing enzymes in rat liver induced by ethanol, phenoparbital, and 3-methylcholanthrene. Toxicol. Appl. Pharmacol. 102, 6449-6455.
27. National Academy of Sciences (NAS) (1987). Pharmacokinetics in Risk Assessment: Drinking Water and Health, Vol. 8, National Academy Press, Washington, DC.
28. Ramsey, J. R., and Andersen, M. E. (1984). A physiologically based description of the inhalation pharmacokinetics of styrene in rats and humans. Toxicol. Appl. Pharmacol. 73, 159-175.
29. Raucy, J. L., Kraner, J. C., and Lasker, J. M. (1993). Bioactivation of halogenated hydrocarbons by cytochrome P4502E1. Crit. Rev. Toxicol. 23, 1-20.
30. Reitz, R. H., McDougal, J. N., Himmelstein, M. W., Nolan, R. J., and Schumann, A. M. (1988). Physiologically based pharmacokinetic modeling with methylchloroform; Implications for interspecies, high dose/low dose and dose/route extrapolations. Toxicol. Appl. Pharmacol. 95, 185-199.
31. Reitz, R. H., Mendrala, A. L., and Guengerich, F. P. (1989). In vitro metabolism of methylene chloride in human and animal tissues: Use in physiologically based pharmacokinetic models. Toxicol. Appl. Pharmacol. 97, 230-246.
32. Reitz, R. H., Mendrala, A. M., Corley, R. A., Quast, J. F., Gargas, M. L., Andersen, M. E., Staats, D. A., and Conolly, R. B. (1990a). Estimating the risk of liver cancer associated with human exposures to chloroform using physiologically based pharmacokinetic modeling. Toxicol. Appl. Pharmacol. 105, 443-459.
33. Reitz, R. H., McCroskey, P. S., Park, C. N., Andersen, M. E., and Gargas, M. L. (1990b). Development of a physiologically based pharmacokinetic model for risk assessment with 1,4-dioxane. Toxicol. Appl. Pharmacol. 105, 37-54.
34. Sato, A., and Nakajima, T. (1979). Partition coefficients of some aromatic hydrocarbons and ketones in water, blood, and oil. Br. J. Ind. Med. 36, 231-234.
35. Simonato, L., L'Abbe, K. A., Andersen, A., Belli, S., Comba, P., Engholm, G., Ferro, G., Hagmar, L., Langard, S., Lundberg, I., Perastu, R., Thomas, P., Winkelmann, R., and Saracci, R. (1991). A collaborative study of cancer incidence and mortality among vinyl chloride workers. Scand. J. Work Environ. Health 17, 159-169.
36. Viola, P. L. (1970). Pathology of vinyl chloride. Med. Lav. 61, 174.
37. Viola, P. L., Bigotti, A., and Caputo, A. (1971). Oncogenic response of rat skin, lungs, and bones to vinyl chloride. Cancer Res. 31, 516-522.
38. 14C-vinyl chloride following inhalation exposure in rats. Toxicol. Appl. Pharmacol. 37, 49-59.