Effect of oropharyngeal length in drug lung delivery via suspension pressurized metered dose inhalers

Pharmaceutical Research

Volumn 23, Issue 6, 2006, Pages 1364-1372

  Ehtezazi, T ^a   Allanson, D R ^a   Jenkinson, I D ^a   O'Callaghan, C ^b  

^a LIVERPOOL JOHN MOORES UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

Oropharyngeal length; Orophryngeal models, the upper airway; Pressurized metered dose inhaler; Small volume spacers

Indexed keywords

EVOHALER; SALBUTAMOL;

ADULT; AEROSOL; ARTICLE; DRUG DELIVERY SYSTEM; HUMAN; HUMAN EXPERIMENT; LUNG; METERED DOSE INHALER; OROPHARYNX; PRIORITY JOURNAL; SUSPENSION;

ADMINISTRATION, INHALATION; AEROSOLS; ALBUTEROL; BRONCHODILATOR AGENTS; DRUG DELIVERY SYSTEMS; HUMANS; INHALATION SPACERS; METERED DOSE INHALERS; MODELS, ANATOMIC; OROPHARYNX; SUSPENSIONS;

EID: 33745330398     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-006-0163-3     Document Type: Article

References (47)

1. A. J. Hickey R. M. Evans 1996 Aerosol generation from propellant-driven metered dose inhalers A. J. Hickey Inhalation Aerosols, Vol. 94 Marcel Dekker New York 417 439
2. H. D. Smyth 2003 The influence of formulation variables on the performance of alternative propellant-driven metered dose inhalers Adv. Drug Deliv. Rev. 55 807 828
3. P. W. Barry C. O'Callaghan 1997 In vitro comparison of the amount of salbutamol available for inhalation from different formulations used with different spacer devices Eur. Respir. J. 10 1345 1348
4. A. R. Clark 1996 MDIs: physics of aerosol formation J. Aerosol Med. 9 S19 S26
5. S. Newman G. Pitcairn K. Steed A. Harrison J. Nagel 1999 Deposition of fenoterol from pressurized metered dose inhalers containing hydrofluoroalkanes J. Allergy Clin. Immunol. 104 S253 S257
6. C. L. Leach P. J. Davidson B. E. Hasselquist R. J. Boudreau 2002 Lung deposition of hydrofluoroalkane-134a beclomethasone is greater than that of chlorofluorocarbon fluticasone and chlorofluorocarbon beclomethasone: a cross-over study in healthy volunteers Chest 122 510 516
7. E. Berg J. Madsen H. Bisgaard 1998 In vitro performance of three combinations of spacers and pressurized metered dose inhalers for treatment in children Eur. Respir. J. 12 472 476
8. R. N. Dalby A. J. Hickey S. L. Tiano 1996 Medical devices for the delivery of therapeutic aerosols to the lungs A. J. Hickey Inhalation Aerosols, Vol. 94 Marcel Dekker New York 441 473
9. S. P. Newman K. P. Steed G. Hooper J. I. Jones F. C. Upchurch 1999 Improved targeting of beclomethasone diproprionate (250 μg metered dose inhaler) to the lungs of asthmatics with the Spacehaler™ Respir. Med. 93 424 431
10. G. R. Dickens D. P. Wermeling C. J. Matheny W. John W. Abramowitz S. M. Sista T. Foster S. Choudhury 2000 Pharmacokinetics of flunisolide administered via metered dose inhaler with and without a spacer device and following oral administration Ann. Allergy Asthma Immunol. 84 528 532
11. P. H. Hirst G. R. Pitcairn J. C. Richards S. Rohatagi M. S. Gillen S. P. Newman 2001 Deposition and pharmacokinetics of an HFA formulation of triamcinolone acetonide delivered by pressurized metered dose inhaler J. Aerosol Med. 14 155 165
12. J. Richards P. Hirst G. Pitcairn S. Mahashabde W. Abramowitz A. Nolting S. P. Newman 2001 Deposition and pharmacokinetics of flunisolide delivered from pressurized inhalers containing non-CFC and CFC propellants J. Aerosol Med. 14 197 208
13. J. Anhoj L. Thorsson H. Bisgaard 2000 Lung deposition of inhaled drugs increases with age Am. J. Respir. Crit. Care Med. 162 1819 1822
14. L. Agertoft L. W. Laulund L. I. Harrison S. Pedersen 2003 Influence of particle size on lung deposition and pharmacokinetics of beclomethasone dipropionate in children Pediatr. Pulmonol. 35 192 199
15. S. G. Devadason T. Huang S. Walker R. Troedson P. N. Le Souef 2003 Distribution of technetium-99m-labelled QVAR delivered using an Autohaler device in children Eur. Respir. J. 21 1007 1011
16. N. C. Miller A. M. Purrington 1996 A cascade impactor entry port for MDI sprays with collection characteristics imitating a physical model of the human throat Pharm. Res. 13 391 397
17. P. B. Myrdal S. W. Stein E. Mogalian W. Hoye A. Gupta 2004 Comparison of the TSI Model 3306 Impactor Inlet with the Andersen Cascade Impactor: solution metered dose inhalers Drug Dev. Ind. Pharm. 30 859 868
18. E. Mogalian P. B. Myrdal 2005 Application of USP inlet extensions to the TSI impactor system 3306/3320 using HFA 227 based solution metered dose inhalers Drug Dev. Ind. Pharm. 31 977 985
19. W. Hofmann T. B. Martonen R. C. Graham 1989 Predicted deposition of nonhygroscopic aerosols in the human lung as a function of subject age J. Aerosol Med. 2 49 68
20. M. J. Oldham R. C. Mannix R. F. Phalen 1997 Deposition of monodisperse particles in hollow models representing adult and child-size tracheobronchial airways Health Phys. 72 827 834
21. W. H. Finlay C. F. Lange M. King D. P. Speert 2000 Lung delivery of aerosolized dextran Am. J. Respir. Crit. Care Med. 161 91 97
22. R. F. Phalen M. J. Oldham C. B. Beaucage T. T. Crocker J. Mortensen 1985 Postnatal enlargement of human tracheobronchial airways and implications for particle deposition Anat. Rec. 212 368 380
23. R. F. Phalen M. J. Oldham 2001 Methods for modeling particle deposition as a function of age Respir. Physiol. 128 119 130
24. R. P. Subramaniam B. Asgharian J. I. Freijer F. J. Miller S. Anjilvel 2003 Analysis of lobar differences in particle deposition in the human lung Inhal. Toxicol. 15 1 21
25. P. H. Hirst G. R. Pitcairn J. G. Weers T. E. Tarara A. R. Clark L. A. Dellamary G. Hall J. Shorr S. P. Newman 2002 In vivo lung deposition of hollow porous particles from a pressurized metered dose inhaler Pharm. Res. 19 258 264
26. L. Borgstrom T. Bengtsson E. Derom R. Pauwels 2000 Variability in lung deposition of inhaled drug, within and between asthmatic patients, with a pMDI and a dry powder inhaler, Turbuhaler Int. J. Pharm. 193 227 230
27. T. Ehtezazi M. A. Horsfield P. W. Barry C. O'Callaghan 2004 Dynamic change of the upper airway during inhalation via aerosol devices J. Aerosol Med. 17 325 334
28. G. Rudolf R. Köbrich W. Stahlhofen 1990 Modeling and algebraic formulation of regional deposition in man J. Aerosol Sci. 21 S403 S406
29. A. R. Clark S. P. Newman N. Dasovich 1998 Mouth and oropharyngeal deposition of pharmaceutical aerosols J. Aerosol Med. 11 S116 S121
30. C. S. Kim M. A. Eldridge M. A. Sackner 1987 Oropharyngeal deposition and delivery aspects of metered-dose inhaler aerosols Am. Rev. Respir. Dis. 135 157 164
31. S. W. Stein B. J. Gabrio 2000 Understanding throat deposition during cascade impaction testing P. R. Byron R. N. Dalby S. J. Farr J. Peart Respiratory Drug Delivery VII Serentec Press Raleigh, NC 287 290
32. Y. S. Cheng C. S. Fu D. Yazzie Y. Zhou 2001 Respiratory deposition patterns of salbutamol pMDI with CFC and HFA-134a formulations in a human airway replica J. Aerosol Med. 14 255 266
33. T. Ehtezazi K. W. Southern D. Allanson I. Jenkinson C. O'Callaghan 2005 Suitability of the upper airway models obtained from MRI studies in simulating drug lung deposition from inhalers Pharm. Res. 22 166 170
34. K. Svartengren P. Lindestad M. Svartengren K. Philipson G. Bylin P. Camner 1995 Added external resistance reduces oropharyngeal deposition and increases lung deposition of aerosol particles in asthmatics Am. J. Respir. Crit. Care Med. 152 32 37
35. C. O'Callaghan J. Lynch M. Cant C. Robertson 1993 Improvement in sodium cromoglycate delivery from a spacer device by use of an antistatic lining, immediate inhalation, and avoiding multiple actuations of drug Thorax 48 603 606
36. J. H. Wildhaber G. W. Waterer G. L. Hall Q. A. Summers 2000 Reducing electrostatic charge on spacer devices and bronchodilator response Br. J. Clin. Pharmacol. 50 277 280
37. B. Olsson L. Borgstrom L. Asking E. Bondesson 1996 Effect of inlet throat on the correlation between measured fine particle dose and lung deposition R. N. Dalby P. R. Byron S. J. Farr Respiratory Drug Delivery V Interpharm Press Buffalo Grove, IL 273 281
38. R. Janssen M. Weda M. B. Ekkelenkamp J. W. Lammers P. Zanen 2002 Metal versus plastic spacers: an in vitro and in vivo comparison Int. J. Pharm. 245 93 98
39. M. Crampton R. Kinnersley J. Ayres 2004 Sub-micrometer particle production by pressurized metered dose inhalers J. Aerosol Med. 17 33 42
40. C. Dytham. Choosing and Using Statistics. A Biologist's Guide, Blackwell, 2003.
41. M. Bland. An Introduction to Medical Statistics, Oxford University Press, 2000.
42. J. C. Dubus C. Marguet A. Deschildre L. Mely P. Le Roux J. Brouard L. Huiart 2001 Local side-effects of inhaled corticosteroids in asthmatic children: influence of drug, dose, age, and device Allergy 56 944 948
43. A. M. Wilson H. J. Brewster B. J. Lipworth 1998 Dose-response comparison of systemic bioactivity with inhaled budesonide and triamcinolone acetonide in asthmatic adults J. Allergy Clin. Immunol. 102 751 756
44. A. F. Heenan E. Matida A. Pollard W. H. Finlay 2003 Experimental measurements and computational modeling of the flow field in an idealized human oropharynx Exp. Fluids 35 70 84
45. O. Aswania H. Chrystyn 2001 Relative lung bioavailability of generic sodium cromoglycate inhalers used with and without a spacer device Pulm. Pharmacol. Ther. 14 129 133
46. P. H. Hirst R. E. Bacon G. R. Pitcairn M. Silvasti S. P. Newman 2001 A comparison of the lung deposition of budesonide from Easyhaler, Turbuhaler and pMDI plus spacer in asthmatic patients Respir. Med. 95 720 727
47. C. Leach 1999 Effect of formulation parameters on hydrofluoroalkane- beclomethasone dipropionate drug deposition in humans J. Allergy Clin. Immunol. 104 S250 S252