Metal versus plastic spacers: An in vitro and in vivo comparison

International Journal of Pharmaceutics

Volumn 245, Issue 1-2, 2002, Pages 93-98

  Janssen, R ^a   Weda, M ^b   Ekkelenkamp, M B ^b   Lammers, J W J ^a   Zanen, P ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

Author keywords

Bronchodilation; In vitro; Nebuchamber ; Salbutamol; Volumatic

Indexed keywords

METAL; PLACEBO; PLASTIC; POLYCARBONATE; POTASSIUM; SALBUTAMOL;

ADULT; ARTICLE; ASTHMA; BRONCHODILATATION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DEVICE; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG DELIVERY SYSTEM; DRUG EFFECT; FEMALE; FORCED EXPIRATORY VOLUME; HEART RATE; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INTERMETHOD COMPARISON; MALE; METERED DOSE INHALER; PARTICLE SIZE; POTASSIUM BLOOD LEVEL; PRIORITY JOURNAL; TREATMENT OUTCOME;

EID: 0036805840     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(02)00330-7     Document Type: Article

References (14)

1. Barry P.W., O'Callaghan C. Multiple actuations of salbutamol MDI into a spacer device reduce the amount of drug recovered in the respirable range. Eur. Respir. J. 7:1994;1707-1709.
2. Barry P.W., O'Callaghan C. In vitro comparison of the amount of salbutamol available for inhalation from different formulations used with different spacer devices. Eur. Respir. J. 10:1997;1345-1348.
3. Berg E., Madsen J., Bisgaard H. In vitro performance of three combinations of spacers and pressurized metered dose inhalers for treatment in children. Eur. Respir. J. 12:1998;472-476.
4. Bisgaard H. A metal aerosol holding chamber devised for young children with asthma. Eur. Respir. J. 8:1995;787-791.
5. Janssens H.M., Devadason S.G., Hop W.C.J., LeSouëf P.N., de Jongste J.C., Tiddens H.A.W.M. Variability of aerosol delivery via spacer devices in young asthmatic children in daily life. Eur. Respir. J. 13:1999;787-791.
6. Kenyon C.J., Thorsson L., Borgström L., Newman S.P. The effects of static charge in spacer devices on glucocorticosteroid aerosol deposition in asthmatic patients. Eur. Respir. J. 11:1998;606-610.
7. Kim C.S., Eldridge M.A., Sackner M.A. Oropharyngeal deposition and delivery aspects of MDI aerosols. Am. Rev. Respir. Dis. 135:1987;157-164.
8. Koning P. Spacer devices used with MDI, break through or gimmick? Chest. 88:1985;276-284.
9. Newman S.P., Moren F., Trofast E., Talae E., Clarke S.W. Terbutaline sulphate Turbuhaler: effect of inhaled flow rate on drug deposition and efficacy. Int. J. Pharm. 74:1991;209-213.
10. Levison H., Reilly P.A., Worsley H. Spacing devices and MDIs in childhood asthma. J. Pediatr. 107:1985;662-668.
11. Pierart F., Wildhaber J.H., Vrancken I., Devadason S.G., LeSouef P.N. Washing spacers in household detergent reduces electrostatic charge and greatly improves delivery. Eur. Respir. J. 13:1999;673-678.
12. Wildhaber J.H., Devadason S.G., Eber E., Hayden M.J., Everard M.L., Summers Q.A., LeSouef P.N. Effect of electrostatic charge, flow, delay and multiple actuations on the in vitro delivery of salbutamol from different small volume spacers for infants. Thorax. 51:1996;985-988.
13. Wildhaber J.H., Devadason S.G., Hayden M.J., James R., Dufty A.P., Fox R.A., Summers Q.A., LeSouef P.N. Electrostatic charge on a plastic spacer device influences the delivery of salbutamol. Eur. Respir. J. 9:1996;1943-1946.
14. Wildhaber J.H., Waterer G.W., Hall G.L., Summers Q.A. Reducing electrostatic charge on spacer devices and bronchodilator response. Br. J. Clin. Pharmacol. 50:2000;277-280.