Neurotoxic pyridinium metabolites of haloperidol are substrates of human organic cation transporters

Drug Metabolism and Disposition

Volumn 34, Issue 7, 2006, Pages 1145-1151

  Kang, Ho Jin ^a,b   Lee, Sang Seop ^a   Lee, Chung Hee ^a   Shim, Ju Cheol ^a   Shin, Ho Jung ^a   Liu, Kwang Hyeon ^a   Yoo, Mi Ae ^b   Shin, Jae Gook ^a,c  

^a Inje University College of Medicine   (South Korea)

^b Pusan National University   (South Korea)

^c Inje University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 (CHLOROPHENYL) 1-4 (FLUOROPHENYL) 4 HYDROXYBUTYL PYRIDINIUM; 4 (4 CHLOROPHENYL) 1 [4 (4 FLUOROPHENYL) 4 OXYBUTYL]PYRIDINIUM ION; CIMETIDINE; CORTICOSTERONE; HALOPERIDOL; ORGANIC CATION TRANSPORTER; PHENOXYBENZAMINE; PYRIDINIUM DERIVATIVE; UNCLASSIFIED DRUG; VERAPAMIL;

ARTICLE; BRAIN; CELL STRAIN CACO 2; CONCENTRATION RESPONSE; DRUG ACCUMULATION; DRUG ACTIVITY; DRUG EFFECT; DRUG MECHANISM; DRUG TRANSFORMATION; HUMAN; HUMAN CELL; LIVER; NEUROTOXICITY; PRIORITY JOURNAL;

ANIMALS; ANTIPSYCHOTIC AGENTS; CACO-2 CELLS; CIMETIDINE; CORTICOSTERONE; HALOPERIDOL; HUMANS; KINETICS; ORGANIC CATION TRANSPORT PROTEINS; ORGANIC CATION TRANSPORTER 1; PHENOXYBENZAMINE; PYRIDINIUM COMPOUNDS; TRANSFECTION;

EID: 33745287191     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.105.009126     Document Type: Article

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