Adenoviral vectors encoding tumor necrosis factor-α and FasL induce apoptosis of normal and tumoral anterior pituitary cells

Journal of Endocrinology

Volumn 189, Issue 3, 2006, Pages 681-690

  Candolfi, M ^a,b   Jaita, G ^a   Pisera, D ^a   Ferrari, L ^a   Barcia, C ^b   Liu, C ^b   Yu, J ^c   Liu, G ^c   Castro, Maria G ^b   Seilicovich, A ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; BETA GALACTOSIDASE; FAS LIGAND; GROWTH HORMONE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR 1;

ADENOHYPOPHYSIS; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CULTURE; CELL CYCLE; CELL VIABILITY; CONTROLLED STUDY; CYTOMEGALOVIRUS; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; GENE OVEREXPRESSION; HYPOPHYSIS ADENOMA; HYPOPHYSIS CELL; IMMUNOCYTOCHEMISTRY; IMMUNOREACTIVITY; MORPHOLOGY; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; RAT; SIGNAL TRANSDUCTION; VIRAL GENE DELIVERY SYSTEM;

ADENOVIRIDAE; ANIMALS; APOPTOSIS; CELL LINE, TUMOR; FAS LIGAND PROTEIN; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; GENETIC VECTORS; IMMUNOHISTOCHEMISTRY; MEMBRANE GLYCOPROTEINS; PITUITARY GLAND, ANTERIOR; PITUITARY NEOPLASMS; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; TUMOR NECROSIS FACTOR-ALPHA; TUMOR NECROSIS FACTORS;

EID: 33745286794     PISSN: 00220795     EISSN: None     Source Type: Journal    
DOI: 10.1677/joe.1.06594     Document Type: Article

References (55)

1. Aggarwal BB & Natarajan K 1996 Tumor necrosis factors: developments during the last decade. European Cytokine Network 7 93-124.
2. Alexander JM, Biller BM, Bikkal H, Zervas NT, Arnold A & Klibanski A 1990 Clinically nonfunctioning pituitary tumors are monoclonal in origin. Journal of Clinical Investigation 86 336-340.
3. Ambar BB, Frei K, Malipiero U, Morelli AE, Castro MG, Lowenstein PR & Fontana A 1999 Treatment of experimental glioma by administration of adenoviral vectors expressing Fas ligand. Human Gene Therapy 10 1641-1648.
4. Asa SL & Ezzat S 2002 The pathogenesis of pituitary tumours. Nature Reviews in Cancer 2 836-849.
5. Ashkenazi A & Dixit VM 1998 Death receptors: signaling and modulation. Science 281 1305-1308.
6. Bianco SR, Sun J, Fosmire SP, Hance K, Padilla ML, Ritt MG, Getzy DM, Duke RC, Withrow SJ, Lana S et al. 2003 Enhancing antimelanoma immune responses through apoptosis. Cancer Gene Therapy 10 726-736.
7. Candolfi M, Zaldivar V, De Laurentiis A, Jaita G, Pisera D & Seilicovich A 2002 TNF-alpha induces apoptosis of lactotropes from female rats. Endocrinology 143 3611-3617.
8. Candolfi M, Jaita G, Zaldivar V, Zarate S, Pisera D & Seilicovich A 2004 Tumor necrosis factor-alpha-induced nitric oxide restrains the apoptotic response of anterior pituitary cells. Neuroendocrinology 80 83-91.
9. Candolfi M, Jaita G, Zaldivar V, Zarate S, Ferrari L, Pisera D, Castro MG & Seilicovich A 2005 Progesterone antagonizes the permissive action of estradiol on tumor necrosis factor-alpha-induced apoptosis of anterior pituitary cells. Endocrinology 146 736-743.
10. Carri NG, Sosa YE, Brown OA, Albarino C, Romanowski V & Goya RG 2005 Studies on in vivo gene transfer in pituitary tumors using herpes-derived and adenoviral vectors. Brain Research Bulletin 65 17-22.
11. Castro MG, Goya RG, Sosa YE, Rowe J, Larregina A, Morelli A & Lowenstein PR 1997 Expression of transgenes in normal and neoplastic anterior pituitary cells using recombinant adenoviruses: long term expression, cell cycle dependency, and effects on hormone secretion. Endocrinology 138 2184-2194.
12. Cecconi F 1999 Apaf1 and the apoptotic machinery. Cell Death Differentiation 6 1087-1098.
13. Chen G & Goeddel DV 2002 TNF-R1 signaling: a beautiful pathway. Science 296 1634-1635.
14. Davis JR, McVerry J, Lincoln GA, Windeatt S, Lowenstein PR, Castro MG & McNeilly AS 2001 Cell type-specific adenoviral transgene expression in the intact ovine pituitary gland after stereotaxic delivery: an in vivo system for long-term multiple parameter evaluation of human pituitary gene therapy. Endocrinology 142 795-801.
15. Degterev A, Boyce M & Yuan J 2003 A decade of caspases. Oncogene 22 8543-8567.
16. Ehtesham M, Samoto K, Kabos P, Acosta FL, Gutierrez MA, Black KL & Yu JS 2002 Treatment of intracranial glioma with in situ interferon-gamma and tumor necrosis factor-alpha gene transfer. Cancer Gene Therapy 9 925-934.
17. Eischen CM, Packham G, Nip J, Fee BE, Hiebert SW, Zambetti GP & Cleveland JL 2001 Bcl-2 is an apoptotic target suppressed by both c-Myc and E2F-1. Oncogene 20 6983-6993.
18. Evan G & Littlewood T 1998 A matter of life and cell death. Science 281 1317-1322.
19. Gatti S & Bartfai T 1993 Induction of tumor necrosis factor-alpha mRNA in the brain after peripheral endotoxin treatment: comparison with interleukin-1 family and interleukin-6. Brain Research 624 291-294.
20. Gonzalvez F, Pariselli F, Dupaigne P, Budihardjo I, Lutter M, Antonsson B, Diolez P, Manon S, Martinou JC, Goubern M et al. 2005 tBid interaction with cardiolipin primarily orchestrates mitochondrial dysfunctions and subsequently activates Bax and Bak. Cell Death Differentiation 12 614-626.
21. Goujon E, Parnet P, Laye S, Combe C & Dantzer R 1996 Adrenalectomy enhances pro-inflammatory cytokines gene expression, in the spleen, pituitary and brain of mice in response to lipopolysaccharide. Brain Research Molecular Brain Research 36 53-62.
22. Hashi A, Mazawa S, Kato J & Arita J 1995 Pentobarbital anesthesia during the proestrous afternoon blocks lactotroph proliferation occurring on estrus in female rats. Endocrinology 136 4665-4671.
23. Herman V, Fagin J, Gonsky R, Kovacs K & Melmed S 1990 Clonal origin of pituitary adenomas. Journal of Clinical Endocrinology and Metabolism 71 1427-1433.
24. Huang P, Tofighi R, Emgard M & Ceccatelli S 2005 Cell death induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) in AtT-20 pituitary cells. Toxicology 207 391-399.
25. Jaita G, Candolfi M, Zaldivar V, Ferrari L, Pisera D, Castro M & Seilicovich A 2005a Influence of 17β-estradiol on the Fas/FasL system in the anterior pituitary. In 87th Annual Meeting of the Endocrine Society, San Diego, CA, USA, p 667.
26. Jaita G, Candolfi M, Zaldivar V, Zarate S, Ferrari L, Pisera D, Castro MG & Seilicovich A 2005b Estrogens up-regulate the Fas/FasL apoptotic pathway in lactotropes. Endocrinology 146 4737-4744.
27. Kobayashi H, Fukata J, Murakami N, Usui T, Ebisui O, Muro S, Hanaoka I, Inoue K, Imura H & Nakao K 1997 Tumor necrosis factor receptors in the pituitary cells. Brain Research 758 45-50.
28. Ksontini R, MacKay SL & Moldawer LL 1998 Revisiting the role of tumor necrosis factor alpha and the response to surgical injury and inflammation. Archives in Surgery 133 558-567.
29. Larregina AT, Morelli AE, Dewey RA, Castro MG, Fontana A & Lowenstein PR 1998 FasL induces Fas/Apo1-mediated apoptosis in human embryonic kidney 293 cells routinely used to generate E1-deleted adenoviral vectors. Gene Therapy 5 563-568.
30. Lee EJ & Jameson JL 2002 Cell-specific Cre-mediated activation of the diphtheria toxin gene in pituitary tumor cells: potential for cytotoxic gene therapy. Human Gene Therapy 13 533-542.
31. Lee EJ & Jameson JL 2005 Gene therapy of pituitary diseases. Journal of Endocrinology 185 353-362.
32. Lee EJ, Anderson LM, Thimmapaya B & Jameson JL 1999 Targeted expression of toxic genes directed by pituitary hormone promoters: a potential strategy for adenovirus-mediated gene therapy of pituitary tumors. Journal of Clinical Endocrinology and Metabolism 84 786-794.
33. Lee EJ, Thimmapaya B & Jameson JL 2000 Stereotactic injection of adenoviral vectors that target gene expression to specific pituitary cell types: implications for gene therapy. Neurosurgery 46 1461-1468, discussion 1468-1469.
34. Lee EJ, Duan WR, Jakacka M, Gehm BD & Jameson JL 2001a Dominant negative ER induces apoptosis in GH(4) pituitary lactotrope cells and inhibits tumor growth in nude mice. Endocrinology 142 3756-3763.
35. Lee EJ, Martinson F, Kodar T, Thimmapaya B & Jameson JL 2001b Adenovirus-mediated targeted expression of toxic genes to adrenocorticotropin-producing pituitary tumors using the proopiomelanocortin promoter. Journal of Clinical Endocrinology and Metabolism 86 3400-3409.
36. Lewis M, Tartaglia LA, Lee A, Bennett GL, Rice GC, Wong GH, Chen EY & Goeddel DV 1991 Cloning and expression of cDNAs for two distinct murine tumor necrosis factor receptors demonstrate one receptor is species specific. PNAS 88 2830-2834.
37. Lowenstein PR SA, Bain D, Castro MG & Wilkinson GWG 1996 The use of adenovirus vectors to transfer genes to identified target brain cells 'in vitro.' In Protocols for Gene Transfer in Neuroscience Towards Gene Therapy of Neurological Disorders, pp 81-92. Ed PR Lowenstein. New York, NY, USA: John Wiley.
38. Maleniak TC, Darling JL, Lowenstein PR & Castro MG 2001 Adenovirus-mediated expression of HSV1-TK or Fas ligand induces cell death in primary human glioma-derived cell cultures that are resistant to the chemotherapeutic agent CCNU. Cancer Gene Therapy 8 589-598.
39. Melmed S 2003 Mechanisms for pituitary tumorigenesis: the plastic pituitary. Journal of Clinical Investigation 112 1603-1618.
40. Morelli AE, Larregina AT, Smith-Arita J, Dewey RA, Southgate TD, Ambar B, Fontana A, Castro MG & Lowenstein PR 1999 Neuronal and glial cell type-specific promoters within adenovirus recombinants restrict the expression of the apoptosis-inducing molecule Fas ligand to predetermined brain cell types, and abolish peripheral liver toxicity. Journal of Gene Virology 80 571-583.
41. Nakanishi H, Mazda O, Satoh E, Asada H, Morioka H, Kishida T, Nakao M, Mizutani Y, Kawauchi A, Kita M et al. 2003 Nonviral genetic transfer of Fas ligand induced significant growth suppression and apoptotic tumor cell death in prostate cancer in vivo. Gene Therapy 10 434-442.
42. Norbury CJ & Zhivotovsky B 2004 DNA damage-induced apoptosis. Oncogene 23 2797-2808.
43. Roche C, Zamora AJ, Taieb D, Lavaque E, Rasolonjanahary R, Dufour H, Bagnis C, Enjalbert A & Bather A 2004 Lentiviral vectors efficiently transduce human gonadotroph and somatotroph adenomas in vitro. Targeted expression of transgene by pituitary hormone promoters. Journal of Endocrinology 183 217-233.
44. Rubinchik S, Yu H, Woraratanadharm J, Voelkel-Johnson C, Norris JS & Dong JY 2003 Enhanced apoptosis of glioma cell lines is achieved by co-delivering FasL-GFP and TRAIL with a complex Ad5 vector. Cancer Gene Therapy 10 814-822.
45. Sanlioglu AD, Aydin C, Bozcuk H, Terzioglu E & Sanlioglu S 2004 Fundamental principals of tumor necrosis factor-alpha gene therapy approach and implications for patients with lung carcinoma. Lung Cancer 44 199-211.
46. Scaffidi C, Schmitz I, Zha J, Korsmeyer SJ, Krammer PH & Peter ME 1999 Differential modulation of apoptosis sensitivity in CD95 type I and type II cells. Journal of Biological Chemistry 274 22532-22538.
47. Smith-Arica JR, Williams JC, Stone D, Smith J, Lowenstein PR & Castro MG 2001 Switching on and off transgene expression within lactotrophic cells in the anterior pituitary gland in vivo. Endocrinology 142 2521-2532.
48. Southgate T, Kingston P & Castro MG 2000a Gene transer into neural cells in vivo using adenoviral vectors. In Current Protocols in Neuroscience, pp 4.23.21-24.23.40. Eds CR Gerfen, R McKay, MA Rogawski, DR Sibley & P Skolnick. New York, NY, USA: John Wiley.
49. Southgate T, Windeatt S, Smith-Arica J, Gerdes C, Perone MJ, Morris I, Davis J, Klatzmann D, Lowenstein PR & Castro MG 2000b Transcriptional targeting to anterior pituitary lactotrophic cells using recombinant adenovirus vectors in vitro and in vivo in normal and estrogen/ supliride-induced hyperplastic anterior pituitaries. Endocrinology 141 3493-3505.
50. Southgate TD, Stone D, Williams JC, Lowenstein PR & Castro MG 2001 Long-term transgene expression within the anterior pituitary gland in situ: impact on circulating hormone levels, cellular and antibody-mediated immune responses. Endocrinology 142 464-476.
51. Watanobe H & Yoneda M 2003 A mechanism underlying the sexually dimorphic ACTH response to lipopolysaccharide in rats: sex steroid modulation of cytokine binding sites in the hypothalamus. Journal of Physiology 547 221-232.
52. Williams JC, Stone D, Smith-Arica JR, Morris ID, Lowenstein PR & Castro MG 2001 Regulated, adenovirus-mediated delivery of tyrosine hydroxylase suppresses growth of estrogen-induced pituitary prolactinomas. Molecular Therapy 4 593-602.
53. Windeatt S, Southgate TD, Dewey RA, Bolognani F, Perone MJ, Larregina AT, Maleniak TC, Morris ID, Goya RG, Klatzmann D et al. 2000 Adenovirus-mediated herpes simplex virus type-1 thymidine kinase gene therapy suppresses oestrogen-induced pituitary prolactinomas. Journal of Clinical Endocrinology and Metabolism 85 1296-1305.
54. Wolvers DA, Marquette C, Berkenbosch F & Haour F 1993 Tumor necrosis factor-alpha: specific binding sites in rodent brain and pituitary gland. European Cytokine Network 4 377-381.
55. Yin P & Arita J 2002 Proestrous surge of gonadotropin-releasing hormone secretion inhibits apoptosis of anterior pituitary cells in cycling female rats. Neuroendocrinology 76 272-282.