Reevaluation of the importance of barrier dysfunction in the nonlesional dry skin of atopic dermatitis patients through the use of two barrier creams

Exogenous Dermatology

Volumn 3, Issue 6, 2006, Pages 293-302

  Matsuki, Hayato ^a   Kiyokane, Kimihiro ^a   Matsuki, Takahiro ^b   Sato, Sayuri ^b   Imokawa, Genji ^c,d  

^a OSAKA MEDICAL COLLEGE   (Japan)

^b FUKUOKA SANNO HOSPITAL   (Japan)

^c Skin Science Research Institute   (Japan)

^d Skin Science Research Institute   (Japan)

Author keywords

Atopic dermatitis; Barrier function; Ceramide cream; Skin care; Transepidermal water loss

Indexed keywords

ANTIALLERGIC AGENT; BETAMETHASONE DIPROPIONATE; CERAMIDE; CLEMASTINE FUMARATE; CLOBETASONE BUTYRATE; CUREL; DEXAMETHASONE DERIVATIVE; DEXAMETHASONE DIPROPIONATE; DEXAMETHASONE PROPIONATE; EBASTINE; EPINASTINE; HIRUDOID; HIRUDOIDO; MEQUITADINE; OLOPATADINE; UNCLASSIFIED DRUG; WATER;

ADOLESCENT; ADULT; ARTICLE; ATOPIC DERMATITIS; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CREAM; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG EFFICACY; DRUG STRUCTURE; DRY SKIN; ELECTRIC CAPACITANCE; EVALUATION; FEMALE; GENERAL CONDITION IMPROVEMENT; HUMAN; JAPAN; LOTION; MALE; PERMEABILITY BARRIER; PRIORITY JOURNAL; PRURITUS; SCHOOL CHILD; SCORING SYSTEM; SKIN BARRIER DYSFUNCTION; SKIN CARE; SKIN DISEASE; SKIN FUNCTION; SKIN SCALING; SKIN WATER LOSS; WATER DEFICIT;

EID: 33745274812     PISSN: 14244616     EISSN: None     Source Type: Journal    
DOI: 10.1159/000091910     Document Type: Article

References (36)

1. Imokawa G: Skin moisturizers: Development and clinical use of ceramides; in Loden M (ed): Dry Skin and Moisturizers. Boca Raton, CRC Press, 1999, pp 269-299.
2. Imokawa G: Ceramides as natural moisturizing factors and their efficacy in dry skin; in Leyden JJ, Rawlings AV (eds): Skin Moisturization. New York, Marcel Dekker, 2002, pp 267-302.
3. Imokawa G, Abe A, Jin K, Higaki Y, Kawashima M, Hidano A: Decreased level of ceramides in stratum corneum of atopic dermatitis: an etiologic factor in atopic dry skin? J Invest Dermatol 1991;96:523-526.
4. Hata M, Tokura Y, Takigawa M, Sato M, Shioya Y, Fujikura Y, Imokawa G: Assessment of epidermal barrier function by photoacoustic spectrometry in relation to its importance in the pathogenesis of atopic dermatitis. Lab Invest 2002;82:1451-1461.
5. Serup J: A double-blind comparison of two creams containing urea as the active ingredient. Assessment of efficacy and side-effects by non-invasive techniques and a clinical scoring scheme. Acta Derm Venereol Suppl (Stockh) 1992;177:34-43.
6. Loden M, Andersson AC, Lindberg M: Improvement in skin barrier function in patients with atopic dermatitis after treatment with a moisturizing cream (Canoderm). Br J Dermatol 1999;140:264-267.
7. Loden M, Andersson AC, Andersson C, Frodin T, Oman H, Lindberg M: Instrumental and dermatologist evaluation of the effect of glycerine and urea on dry skin in atopic dermatitis. Res Technol 2001;7:209-213.
8. Loden M: Role of topical emollients and moisturizers in the treatment of dry skin barrier disorders. Am J Clin Dermatol 2003;4:771-788.
9. Proksch E, Nissen HP, Bremgartner M, Urquhart C: Bathing in a magnesium-rich Dead Sea salt solution improves skin barrier function, enhances skin hydration, and reduces inflammation in atopic dry skin. Int J Dermatol 2005;44:151-157.
10. Hachem JP, De Paepe K, Vanpee E, Kaufman L, Rogieers V, Roseeuw D: The effect of two moisturisers on skin barrier damage in allergic contact dermatitis. Eur J Dermatol 2002;12:136-138.
11. Fluhr JW, Gloor M, Lehmann L, Lazzerini S, Distante F, Berardesca E: Glycerol accelerates recovery of barrier function in vivo. Acta Derm Venereol 1999;79:418-421.
12. Chamlin SL, Kao J, Frieden IJ, Sheu MY, Fowler AJ, Fluhr JW, Williams ML, Elias PM: Ceramide-dominant barrier repair lipids alleviate childhood atopic dermatitis: changes in barrier function provide a sensitive indicator of disease activity. J Am Acad Dermatol 2002;47:198-208.
13. Brazzelli V, Distante F, Perani G, Berardesca E: Effects of systemic treatment with statins on skin barrier function and stratum corneum water-holding capacity. Dermatology 1996;192:214-216.
14. Chamlin SL, Kao J, Frieden IJ, Sheu MY, Fowler AJ, Fluhr JW, Williams ML, Elias PM: Ceramide-dominant barrier repair lipids alleviate childhood atopic dermatitis: changes in barrier function provide a sensitive indicator of disease activity. J Am Acad Dermatol 2002;47:198-208.
15. Vavrova K, Zbytovska J, Palat K, Holas T, Klimentova J, Hrabalek A, Dolezal P: Ceramide analogue 14S24 ((S)-2-tetracosanoylamino-3-hydroxypropionic acid tetradecyl ester) is effective in skin barrier repair in vitro. Eur J Pharm Sci 2004;21:581-587.
16. Hanifin JM, Rajka G: Diagnostic features of atopic dermatitis. Acta Derm Venereol (Stockh) 1989;92:44-47.
17. Rajka G, Langeland T: Grading of the severity of atopic dermatitis. Acta Dermatovenereol Suppl (Stockh) 1989;144:13-14.
18. Berardesca E: EEMCO guidance for the assessment of stratum comeum hydration: electrical methods. Skin Res Technol 1997;3:126-132.
19. Pinnagoda J, Tupker RA, Agner T, et al: Guidelines for transepidermal water loss (TEWL) measurement. A report from the Standardization Group of the European Society of Contact Dermatitis. Contact Dermatitis 1990;22:164-178.
20. Kuss O, Diepgen TL: Proper statistical analysis of transepidermal water loss (TEWL) measurements in bioengineering studies. Contact Dermatitis 1998;39:64-67.
21. De Paepe K, Houben E, Adam R, Wisemann F, Rogiers V: Validation of the VapoMeter, a closed unventilated chamber system to assess transepidermal water loss vs. the open chamber Tewameter. Skin Res Technol 2005;11:61-69.
22. Imokawa G, Akasaki S, Kawamata A, Yano S, Takaishi N. Water-retaining function in the stratum corneum and its recovery properties by synthetic pseudo-ceramides. J Soc Cosmet Chem 1989;40:273-285.
23. Takagi Y, Nakagawa H, Higuchi K, Imokawa G: Characterization of surfactant-induced skin damage through barrier recovery induced by pseudoacylceramide. Dermatology 2005;211:128-134.
24. Imokawa G, Akasaki S, Minematsu Y, Kuno O, Zama M, Kawai M, Hattori M, Yoshizuka N, Kawamata A, Yano Y, Takaishi N: Function of lipids on human skin. J Disp Sci Tech 1989;10:617-641.
25. Matsuki H, Kiyokane K, Matsuki T, Sato S, Imokawa G: Re-characterization of the non-lesional skin in association with barrier function and the severity of atopic dermatitis (abstract). J Dennatol Sci 2005;38:152-153.
26. Werner Y, Lindberg M: Transepidermal water loss in dry and clinically normal skin in patients with atopic dermatitis. Acta Derm Venereol 1985;65:102-105.
27. Ogawa H, Yoshiike T: A speculative view of atopic dermatitis: barrier dysfunction in pathogenesis. J Dermatol Sci 1993;5:197-204.
28. Watanabe M, Tagami H, Horii I, Takahashi M, Kligman AM: Functional analysis of the superficial stratum corneum in atopic xerosis. Arch Dermatol 1991;127:1689-1692.
29. Imokawa G: Lipid abnormalities in atopic dermatitis. J Am Acad Dermatol 2001;45:S29-S32.
30. Umeda Y, Mizutani H, Imokawa G, Shimizu M: Topical ceramide corrected epidermal cell hyperproliferation and stratum corneum dysmaturation in atopic eczema. New Trends Allergy 1997;4:237-239.
31. Imokawa G, Akasaki S, Minematsu Y, Kawai M: Importance of intercellular lipids in water-retention properties of the stratum corneum: induction and recovery study of surfactant dry skin. Arch Dermatol Res 1989;281:45-51.
32. Imokawa G, Hattori M: A possible function of structural lipid in the water-holding properties of the stratum corneum. J Invest Dermatol 1985;84:282-284.
33. Imokawa G, Kuno H, Kawai M: Stratum corneum lipids serve as a bound-water modulator. J Invest Dermatol 1991;96:845-851.
34. Imokawa G: Water and the stratum corneum; in Elsner P, Berardesca E, Maibach HI (eds): Bioengineering of Skin. In vitro and in vivo Models. Boca Raton, CRC Press, vol 1, chapter 3, 1993, pp 23-47.
35. Imokawa G, Yada Y, Higuchi K, Okuda M, Ohashi Y, Kawamata A: Pseudo- acylceramide with linoleic acid produces selective recovery of diminished cutaneous barrier function in essential fatty acid-deficient rats and has an inhibitory effect on epidermal hyperplasia. J Clin Invest 1994;94:89-96.
36. Kikuchi K, Kobayashi H, Hirao T, Ito A, Takahashi H, Tagami H: Improvement of mild inflammatory changes of the facial skin induced by winter environment with daily applications of a moisturizing cream. Dermatology 2003;207:269-275.