Effects of systemic treatment with statins on skin barrier function and stratum corneum water-holding capacity

Dermatology

Volumn 192, Issue 3, 1996, Pages 214-216

  Bvazzelli, V ^a   Disunite, F ^a   Peranih, G ^a   Berardesca, E ^a  

^a UNIVERSITY OF PAVIA   (Italy)

Author keywords

Cholesterol synthesis; HMG CoA reductase; Skin barrier function; Statins; Transepidermal water loss; Water holding capacity

Indexed keywords

CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; PRAVASTATIN; SIMVASTATIN;

ADULT; ARTICLE; CONTROLLED STUDY; DIET THERAPY; FEMALE; HUMAN; HYPERCHOLESTEROLEMIA; MAJOR CLINICAL STUDY; MALE; ORAL DRUG ADMINISTRATION; PERMEABILITY BARRIER; PRIORITY JOURNAL; SKIN WATER LOSS; STATISTICAL ANALYSIS; STRATUM CORNEUM;

ADMINISTRATION, ORAL; ADULT; ANALYSIS OF VARIANCE; ANTICHOLESTEREMIC AGENTS; CELL MEMBRANE PERMEABILITY; EPIDERMIS; FEMALE; HUMANS; HYPERCHOLESTEROLEMIA; LOVASTATIN; MALE; MIDDLE AGED; PRAVASTATIN; SIMVASTATIN; WATER LOSS, INSENSIBLE;

EID: 0029988444     PISSN: 10188665     EISSN: 14219832     Source Type: Journal    
DOI: 10.1159/000246368     Document Type: Article

References (12)

1. Elias PM: Epidermal lipids, barrier function and desquamation. J Invest Dermatol 1983:80: 44-49.
2. Mao-Qiang M, Feingold KR. Elias PM: Inhibition of cholesterol and sphingolipid synthesis causes paradoxical effects on permeability barrier homeostasis. J Invest Dermatol 1993:101: 185-190.
3. Feingold KR. Mao-Qiang M. Proksch E. Menon GK, Brown BE. Elias PM: The lovas-tatin treated rodent. A new model of barrier disruption and epidermal hyperplasia. J Invest Dermatol 1991:96:201-209.
4. Marcclo C. Duell EA, Rhodes LM. Dunham WR: In vitro model of essential fatty acid deficiency. J Invest Dermatol 1992:99:703-708.
5. Parson VVB. Flintl JH: Reduction of serum cholesterol levels and belalipoprotein cholesterol levels by nicotinic acid. Arch Intern Med 1959:103:783-790.
6. Ruiter M, Mcyler R: Skin changes after therapeutic administration of nicotinic acid in large doses. Dermatologica 1960:120:1.39-144.
7. Ramsing D. Agner E, Malinowski J, Meibom J. Agner T: Effect of systemic treatment with cholesterol-lowering drug on skin barrier function in humans. Acta Derm Venereol (Stockh) 1995;75:198-201.
8. Tagami It. Hardware and measuring principle: Skin conductance: in Eisner P. Berardesca E. Maibach H (eds): Bioengineering of the Skin: Water anti the Stratum Corneum. Boca Raton. CRC Press. 1994, p 197.
9. Elias PM. Williams ML: Neutral lipid storage disease with ichthyosis: Defective lamellar body contents and intercellular dispersion. Arch Dermatol 1985:121:1000-1008.
10. Williams ML. Feingold KR. Grubauer G. Elias PM: Ichthyosis induced by cholesterol-lowering drugs. Arch Dermatol 1987:123: 1535-1538.
11. Krasovec M. Eisner P. Burg G: Generalized eczematous skin rash possibly due to IIMG-CoA reductase inhibitors. Dermatology 1993; 186:248-252.
12. Todd AP, Goa KL: Simvastatin: A review of its pharmacological properties and therapeutic potential in hypercholesterolemia. Drugs 1990:40:583-607.