Effects of 5-HT agonists, selective for different receptor subtypes, on oxytocin, CCK, gastrin and somatostatin plasma levels in the rat

Neuropharmacology

Volumn 35, Issue 11, 1996, Pages 1635-1640

  Uvnäs Moberg, Kerstin ^a   Hillegaart, Viveka ^a   Alster, Pawel ^a   Ahlenius, Sven ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Anxiolytics; Hormones; Radioimmunoassay; Rat; Serotonin receptors

Indexed keywords

1 (3 CHLOROPHENYL)BIGUANIDE; 1 (3 TRIFLUOROMETHYLPHENYL)PIPERAZINE; 2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 4 IODO 2,5 DIMETHOXYAMPHETAMINE; ANXIOLYTIC AGENT; BUSPIRONE; CHOLECYSTOKININ; GASTRIN; OXYTOCIN; PINDOLOL; RECEPTOR SUBTYPE; RITANSERIN; SEROTONIN 1A AGONIST; SEROTONIN 1A ANTAGONIST; SEROTONIN 1B AGONIST; SEROTONIN 2A AGONIST; SEROTONIN 2A ANTAGONIST; SEROTONIN 3 AGONIST; SEROTONIN AGONIST; SEROTONIN RECEPTOR; SOMATOSTATIN;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG SELECTIVITY; HORMONE BLOOD LEVEL; HORMONE RELEASE; NONHUMAN; OXYTOCIN RELEASE; PRIORITY JOURNAL; RADIOIMMUNOASSAY; RAT; SUBCUTANEOUS DRUG ADMINISTRATION;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; AMPHETAMINES; ANIMALS; CHOLECYSTOKININ; GASTRINS; MALE; NEUROPEPTIDES; OXYTOCIN; RADIOIMMUNOASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, SEROTONIN; SEROTONIN AGONISTS; SOMATOSTATIN;

EID: 0030462792     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(96)00078-0     Document Type: Article

References (36)

1. 1A and 5HT2/5HT1C receptors induce oxytocin release in the male rat. Brain Res. 611: 330-332.
2. Bagdy G., Kalogeras K. T. and Szemeredi K. (1992) Effect of 5-HT1C and 5-HT2 receptor stimulation on excessive grooming, penile erection and plasma oxytocin concentrations. Eur. J. Pharmacol. 229: 9-14.
3. 2A receptor agonist 8-OH-DPAT on plasma levels of insulin, cholecystokinin and somatostatin. Regul. Pept. 63: 47-52.
4. Björkstrand E. and Uvnäs-Moberg K. (1996) Central oxytosin increases food intake and daily weight gain in rats. Physiol. Behav. 59: 947-952.
5. Chua A., Keating J., Hamilton D., Keeling P. W. N. and Dinan T. G. (1992) Central serotonin receptors and delayed gastric emptying in non-ulcer dyspepsia. Br. J. Med. 305: 280-282.
6. Chua A. S. B., Bekkering M., Rovati L. C. and Keeling P. W. N. (1994a) Clinical efficacy and prokinetic effect of the CCK-A antagonist loxiglumide in nonulcer dyspepsia. Ann. N.Y. Acad. Sci. 713: 451-453.
7. Chua A. S. B., Dinan T. G., Rovati L. C. and Keeling P. W. N. (1994b) Cholecystokinin hyper-responsiveness in dysmotility-type nonulcer dyspepsia. Ann. N.Y. Acad. Sci. 713: 298-299.
8. Day H. E., McKnight A. T., Poat J. A. and Hughes J. (1994) Evidence that cholecystokinin induces immediate early gene expression in the brainstem, hypothalamus and amygdala of the rat by a CCKA receptor mechanism. Neuropharmacology 33: 719-727.
9. Dinan T. G., Yatham E. N., Barry S., Chua A. and Keeling P. W. N. (1990) Serotonin supersensitivity: the pathophysiologic basis of non-ulcer dyspepsia? A preliminary report of buspirone/prolactin responses. Scand. J. Gastroenterol. 25: 541-544.
10. Efendic S., Enzmann F., Nylén A., Uvnäs-Wallensten K. and Luft R. (1980) Sulphonylurea (Glibenclamide) enhances somatostatin and inhibits glucagon release induced by arginine. Acta Physiol. Scand. 108: 231-233.
11. 125I]-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane: an iodinated ratioligand that specifically labels the agonist high affinity state of 5-HT2 serotonin receptors. J. Med. Chem. 31: 5-7.
12. Goodwin G. M. and Green A. R. (1985) A behavioural and biochemical study in mice and rats of putative selective agonists and antagonists for 5-HT1 and 5-HT2 receptors. Br. J. Pharmacol. 84: 743-753.
13. Himeno S., Tarui S., Kanayama S., Kuroshima T., Shinomura Y., Hayashi C., Tateishi K., Imágawa K., Hashimura E. and Hamaoka T. (1983) Plasma cholecystokinin responses after ingestion of liquiol meal and intraduodenal infusion of fat, amino acids, or hydrochloric acid in man: analysis with region specific radioimmunoassay. Am. J. Gastroenterol. 78: 703-707.
14. Hisano S., Chikamori-Aoyama M., Aizawa T. and Fukui Y. (1993) Somatostatin-like immunoactive axon terminals on oxytocin-like immunoreactive neurons in the paraventricular nucleus of the rat hypothalamus. Neurosci. Lett. 156: 21-23.
15. Hjorth S. and Carlsson A. (1986) Is pindolol a mixed agonist-antagonist at central serotonin (5-HT) receptors? Eur. J. Pharmacol. 129: 131-138.
16. Hjorth S., Carlsson A., Lindberg P., Sanchez D., Wikstrom H., Arvidsson L. E., Hacksell U. and Nilsson J. L. G. (1982) 8-Hydroxy-2-(di-n-propylamino)tetralin, 8-OH-DPAT, a potent and selective simplified ergot congener with central 5-HT-receptor stimulating activity. J. Neural Trans. 55: 169-188.
17. Hoyer D. (1992) Agonists and antagonists at 5-HT receptor subtypes. Adv. Biosci. 85: 29-47.
18. Hoyer D., Clarke D. E., Fozard J. R., Hartig P. R., Martin G. R., Mylecharane E. J., Saxena P. R. and Humphrey P. A. (1994) VII International Union of Pharmacology classification of receptors tor 5-hydroxytryptamine (serotonin). Pharmacol. Rev. 46: 157-203.
19. Kawano S., Osaka T., Kannan H. and Yamashita H. (1992) Excitation of hypothalamic paraventricular neurons by stimulation of the raphe nuclei. Brain Res. Bull. 28: 573-579.
20. Kilpatrick G. J., Butler A., Burridge J. and Oxford A. W. (1990) 1-(m-Chlorophenyl)-biguanide, a potent high affinity 5-HT3 receptor agonist. Eur. J. Pharmacol. 182: 193-197.
21. Leysen J. E., Gommeren W., van Gompel P., Wynants J., Janssen P. F. M. and Laduron P. M. (1985) Receptor binding properties in vitro and in vivo of ritanserin, a very potent and long acting serotonin S2 antagonist. Molec. Pharmacol. 27: 600-611.
22. Li Q., Brownfield M. S., Battaglia G., Cabrera T. M., Levy A. D., Rittenhouse P. A. and Van de Kar L. D. (1993a) Long-term treatment with the antidepressants fluoxetin and desipramine potentiates endocrine responses to the serotonin agonists 6-chloro-2-[1-piperazinyl]-pyrazine (MK-212) and (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane HCL (DOI). J. Pharmacol. Exp. Ther. 266: 836-844.
23. 1A agonist, 8-OH-DPAT, in male rats. Brain Res. 630: 148-156.
24. Luckman S. M., Hamamura M., Antonijevic I., Dye S. and Leng G. (1993) Involvement of cholecystokinin receptor types in pathways controlling oxytocin secretion. Br. J. Pharmacol. 110: 378-384.
25. 1b receptors. Ann. N.Y. Acad. Sci. 600: 132-147.
26. Miller T. R., Bianchi B. R., Witte D. G. and Lin C. W. (1993) Peripheral cholecystokinin type A receptors mediate oxytocin secretion in vivo. Regul. Pept. 43: 107-112.
27. Nilsson G. (1975) Increased plasma gastrin in connection with inhibition of gastric acid response to sham feeding following bulbar perfusion with acid in dogs. Scand. J. Gastroenterol. 10: 273-277.
28. Saydoff J. A., Rittenhouse P. A., van de Kar L. D. and Brownfield M. S. (1991) Enhanced serotonergic transmission stimulates oxytocin secretion in conscious male rats. J. Pharmacol. Exp. Ther. 257: 95-99.
29. Smith G. P., Jerome C., Cushin B. J., Eterno R. and Simansky K. J. (1981) Abdominal vagotomy blocks the satiety effect of cholecystokinin in the rat. Science 213: 1036-1037.
30. Sofroniew M. V. (1985) Vasopressin, oxytocin and their related neurophysins. In: Handbook of Chemical Neuroanatomy. GABA and Neuropeptides in the CNS (Björklund A. and Hökfelt T., Eds), Vol. 4, Part 1, pp. 93-165. Elsevier, Amsterdam.
31. Stock S., Granström L., Backman L., Matthiesen A. S. and Uvnäs-Moberg K. (1989) Elevated plasma levels of oxytocin in obese subjects before and after gastric banding. Int. J. Obes. 13: 213-222.
32. Törk I. (1990) Anatomy of the serotonergic system. Ann. N.Y. Acad. Sci. 600: 9-34.
33. Uvnäs-Moberg K., Alster P. and Svensson T. (1992a) Amperozide and clozapine but not haloperidol or raclopride increase the secretion of oxytocin in rats. Psychopharmacology 109: 473-476.
34. Uvnäs-Moberg K., Alster P., Hillegaart V. and Ahlenius S. (1992b) Oxytocin reduces exploratory motor behaviour and shifts the activity towards the centre of the arena in male rats. Acta Physiol. Scand. 145: 429-430.
35. Uvnäs-Moberg K., Ahlenius S., Hillegaart V. and Alster P. (1994) High doses of oxytocin cause sedation and low doses cause an anxiolytic-like effect in male rats. Pharmacol. Biochem. Behav. 49: 101-106.
36. Wright D. E., Seroogy K. B., Lundgren K. H., Davis B. M. and Jennes L. (1995) Comparative localization of serotonin 1a, 1c and 2 receptor subtype mRNAs in rat brain. J. Comp. Neurol. 351: 357-373.