Variation of ATM protein expression in response to irradiation of lymphocytes in lung cancer patients and controls

Toxicology

Volumn 224, Issue 1-2, 2006, Pages 138-146

  Jianlin, Lou ^a   Jiliang, He ^a,b   Lifen, Jin ^a   Wei, Zheng ^a   Zhijian, Chen ^a   Shijie, Chen ^a   Shijie, Xu ^b  

^a ZHEJIANG UNIVERSITY   (China)

^b JIAXING UNIVERSITY   (China)

Author keywords

ATM protein; Comet assay; Lung cancer; Micronucleus assay; Radiation

Indexed keywords

ADULT; AGED; ARTICLE; BLOOD SAMPLING; CANCER RADIOTHERAPY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; HEPARINIZATION; HUMAN; INFRARED RADIATION; IONIZING RADIATION; LUNG CARCINOMA; LYMPHOCYTE; MALE; MICRONUCLEUS; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING; X RAY ANALYSIS;

ADULT; AGED; AGED, 80 AND OVER; BLOTTING, WESTERN; CELL CYCLE PROTEINS; COMET ASSAY; DNA-BINDING PROTEINS; FEMALE; GENE EXPRESSION REGULATION; HUMANS; LUNG NEOPLASMS; LYMPHOCYTES; MALE; MICRONUCLEUS TESTS; MIDDLE AGED; PROTEIN-SERINE-THREONINE KINASES; TUMOR SUPPRESSOR PROTEINS;

EID: 33745210152     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2006.04.040     Document Type: Article

References (31)

1. Angèle S., Romestaing P., Moullan N., Vuillaume M., Chapot B., Friesen M., Jongmans W., Cox D.G., Pisani P., Gerard J.P., and Hall J. ATM haplotypes and cellular response to DNA damage: association with breast cancer risk and clinical radiosensitivity. Cancer Res. 63 (2003) 8717-8725
2. Angèle S., Falconer A., Edwards S.M., Dörk T., Bremer M., Moullan N., Chapot B., Muir K., Houlston R., Norman A.R., Bullock S., Hope Q., Meitz J., Dearnaley D., Dowe A., Southgate C., and Ardern-jones A. ATM polymorphisms as risk factors for prostate cancer development. Br. J. Cancer 91 (2004) 783-787
3. Baciuchka-Palmaro M., Orsiere T., Duffaud F., Sari-Minodier I., Pompili J., Bellon L., De Meo M., Digue L., Favre R., and Botta A. Acentromeric micronuclei are increased in peripheral blood lymphocytes of untreated cancer patients. Mutat. Res. 520 (2002) 189-198
4. Ban S., Konomi C., Iwakawa M., Yamada S., Ohno T., Tsuji H., Noda S., Matui Y., Harada Y., Cologne J.B., and Imai T. Radiosensitivity of peripheral blood lymphocytes obtained from patients with cancers of the breast, head and neck or cervix as determined with a micronucleus assay. J. Radiat. Res (Tokyo) 45 (2004) 535-541
5. Bishay K., Ory K., Olivier M.F., Lebeau J., Levalois C., and Chevillard S. DNA damage-related RNA expression to assess individual sensitivity to ionizing radiation. Carcinogenesis 22 (2001) 1179-1183
6. Bremer M., Klopper K., Yamini P., Bendix-Waltes R., Dork T., and Karstens J.H. Clinical radiosensitivity in breast cancer patients carrying pathogenic ATM gene mutations: no observation of increased radiation-induced acute or late effects. Radiother. Oncol. 69 (2003) 155-160
7. Colleu-Durel S., Guitton N., Nourgalieva K., Legue F., Leveque J., Danic B., and Chenal C. Alkaline single-cell gel electrophoresis (comet assay): a simple technique to show genomic instability in sporadic breast cancer. Eur. J. Cancer 40 (2004) 445-451
8. Fenech M. The in vitro micronucleus technique. Mutat. Res. 455 (2000) 81-95
9. Fenech M., and Morley A.A. Measurement of micronuclei in lymphocytes. Mutat. Res. 147 (1985) 29-36
10. Goldstine J.V., Nahas S., Gamo K., Gartler S.M., Hansen R.S., Roelfsema J.H., Gatti R.A., and Marahrens Y. Constitutive phosphorylation of ATM in lymphoblastoid cell lines from patients with ICF syndrome without downstream kinase activity. DNA Repair 5 (2006) 432-443
11. Hirai Y., Hayashi T., Kubo Y., Hoki Y., Arita I., Tatsumi K., and Seyama T. X-irradiation induces up-regulation of ATM gene expression in wild-type lymphoblastoid cell lines, but not in their heterozygous or homozygous ataxia-telangiectasia counterparts. Jpn. J. Cancer Res. 92 (2001) 710-717
12. Iannuzzi C.M., Atencio D.P., Green S., Stock R.G., and Rosenstein B.S. ATM mutations in female breast cancer patients predict for an increase in radiation-induced late effects. Int. J. Radiat. Oncol. Biol. Phys. 52 (2002) 606-613
13. Jianlin L., Jiliang H., Lifen J., Wei Z., Baohong W., and Hongping D. Measuring the genetic damage in cancer patients during radiotherapy with three genetic end-points. Mutagenesis 19 (2004) 457-464
14. Kadhim M.A. Role of genetic background in induced instability. Oncogene 22 (2003) 6994-6999
15. Kopjar N., Garaj-Vrhovac V., and Milas I. Assessment of chemotherapy-induced DNA damage in peripheral blood leukocytes of cancer patients using the alkaline comet assay. Teratog. Carcinog. Mutagen. 22 (2002) 13-30
16. Kruger N.J. The Bradford method for protein quantitation. Methods Mol. Biol. 32 (1994) 9-15
17. Li L., Story M., and Legerski R.J. Cellular responses to ionizing radiation damage. Int. J. Radiat. Oncol. Biol. Phys. 49 (2001) 1157-1162
18. Little J.B. Genomic instability and radiation. J. Radiol. Prot. 23 (2003) 173-181
19. Maluf S.W. Monitoring DNA damage following radiation exposure using cytokinesis-block micronucleus method and alkaline single-cell gel electrophoresis. Clin. Chim. Acta 347 (2004) 15-24
20. Mori M., and Desaintes C. Gene expression in response to ionizing radiation: an overview of molecular features in hematopoietic cells. J. Biol. Regul. Homeost. Agents 18 (2004) 363-371
21. Palyvoda O., Polanska J., Wygoda A., and Rzeszowska-Wolny J. DNA damage and repair in lymphocytes of normal individuals and cancer patients: studies by the comet assay and micronucleus tests. Acta Biochim. Pol. 50 (2003) 181-190
22. Peacock J., Ashton A., Bliss J., Bush C., Eady J., Jackson C., Owen R., Regan J., and Yarnold J. Cellular radiosensitivity and complication risk after curative radiotherapy. Radiother. Oncol. 55 (2000) 173-178
23. Schabath M.B., Spitz M.R., Grossman H.B., Zhang K., Dinney C.P., Zheng P.J., and Wu X. Genetic instability in bladder cancer assessed by the comet assay. J. Natl. Cancer Inst. 95 (2003) 540-547
24. Shiloh Y. ATM and related protein kinases: safeguarding genome integrity. Nat. Rev. Cancer 3 (2003) 155-168
25. Singh N.P., McCoy M.T., Tice R.R., and Schneider E.L. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp. Cell. Res. 175 (1988) 184-191
26. Slonina D., and Gasinska A. Intrinsic radiosensitivity of healthy donors and cancer patients as determined by the lymphocyte micronucleus assay. Int. J. Radiat. Biol. 72 (1997) 693-701
27. Smith L.E., Nagar S., Kim G.J., and Morgan W.F. Radiation-induced genomic instability: radiation quality and dose response. Health Phys. 85 (2003) 23-29
28. Sowa Resat M.B., and Morgan W.F. Radiation-induced genomic instability: a role for secreted soluble factors in communicating the radiation response to non-irradiated cells. J. Cell. Biochem. 92 (2004) 1013-1019
29. Tribius S., Pidel A., and Casper D. ATM protein expression correlates with radioresistance in primary glioblastoma cells in culture. Int. J. Radiat. Oncol. Biol. Phys. 50 (2001) 511-523
30. Venkatachalam P., Paul S.F., Mohankumar M.N., Prabhu B.K., Gajendiran N., Kathiresan A., and Jeevanram R.K. Higher frequency of dicentrics and micronuclei in peripheral blood lymphocytes of cancer patients. Mutat. Res. 425 (1999) 1-8
31. Zhang M.B., He J.L., Jin L.F., and Lu D.Q. Study of low-intensity 2450-MHz microwave exposure enhancing the genotoxic effects of mitomycin C using micronucleus test and comet assay in vitro. Biomed. Environ. Sci. 15 (2002) 283-290