Intermolecular palladium-catalyzed coupling of 2-halopyridines and alcohols for the preparation of pyridine ether PPAR agonists

Tetrahedron Letters

Volumn 47, Issue 30, 2006, Pages 5333-5336

  Humphries, Paul S ^a   Bailey, Simon ^a   Do, Quyen Quyen T ^a   Kellum, Jack H ^a   McClellan, Guy A ^a   Wilhite, David M ^a  

^a PFIZER INC   (United States)

Author keywords

Buchwald; Halopyridine; Palladium; PPAR; Pyridine ether

Indexed keywords

ALCOHOL DERIVATIVE; ETHER DERIVATIVE; PALLADIUM; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PYRIDINE DERIVATIVE;

ARTICLE; CATALYSIS; DRUG SYNTHESIS; TECHNIQUE;

EID: 33745183136     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2006.05.133     Document Type: Article

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29. All new compounds were characterized by full spectroscopic data, yields refer to chromatographed material with purity >95%.
30. 3) δ 7.97-7.95 (m, 1H), 7.92 (d, J = 2.1 Hz, 2H), 7.43-7.39 (m, 4H), 6.63 (d, J = 8.5 Hz, 1H), 4.52 (t, J = 6.8 Hz, 2H), 3.70 (s, 3H), 3.32-3.28 (m, 3H), 2.96-2.90 (m, 4H), 2.33 (s, 3H), 1.33 (s, 3H). ESIMS (m/z): 411 (M+H).
31. A modified microwave-assisted intermolecular palladium-catalyzed procedure was never attempted during these investigations.
32. 2O: C, 66.16; H, 6.15; N, 6.96.