Enhanced sensitivity of DJ-1-deficient dopaminergic neurons to energy metabolism impairment: Role of Na+/K+ ATPase

Neurobiology of Disease

Volumn 23, Issue 1, 2006, Pages 54-60

  Pisani, A ^a,b   Martella, G ^a   Tscherter, A ^a   Costa, C ^d   Mercuri, N B ^a,b   Bernardi, G ^a,b   Shen, J ^c   Calabresi, P ^b,d  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b EUROPEAN BRAIN RESEARCH INSTITUTE   (Italy)

^c HARVARD MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF PERUGIA   (Italy)

Author keywords

DJ 1; Dopamine; Electrophysiology; Parkinson's disease; Sodium potassium pump; Substantia nigra

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM) INHIBITOR; GLUCOSE; OUABAIN; OXYGEN; ROTENONE; TOXIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; CELL MEMBRANE; CELL MEMBRANE POTENTIAL; CELL POLARITY; CELL TYPE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORPUS STRIATUM; DEPOLARIZATION; DOPAMINERGIC NERVE CELL; ELECTROPHYSIOLOGY; ENDOCRINE DISEASE; ENERGY METABOLISM; HYPERPOLARIZATION; MITOCHONDRION; MOUSE; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN FUNCTION; SENSITIVITY ANALYSIS; SUBSTANTIA NIGRA;

ANIMALS; CELL HYPOXIA; DISEASE MODELS, ANIMAL; DOPAMINE; ENERGY METABOLISM; ENZYME INHIBITORS; GLUCOSE; MEMBRANE POTENTIALS; MICE; MICE, KNOCKOUT; NA(+)-K(+)-EXCHANGING ATPASE; NEURONS; ONCOGENE PROTEINS; ORGAN CULTURE TECHNIQUES; OUABAIN; PARKINSON DISEASE; PATCH-CLAMP TECHNIQUES; ROTENONE; SUBSTANTIA NIGRA; UNCOUPLING AGENTS;

EID: 33745163261     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2006.02.001     Document Type: Article

References (36)

1. Ballanyi K. Protective role of neuronal KATP channels in brain hypoxia. J. Exp. Biol. 207 (2004) 3201-3212
2. Betarbet R., Sherer T.B., MacKenzie G., Garcia-Osuna M., Panov A.V., and Greenamyre J.T. Chronic systemic pesticide exposure reproduces features of Parkinson's disease. Nat. Neurosci. 3 (2000) 1301-1306
3. Betarbet R., Sherer T.B., and Greenamyre J.T. Ubiquitin-proteasome system and Parkinson's diseases. Exp. Neurol. 191 Suppl. 1 (2005) S17-S27
4. Bonifati V., Rizzu P., van Baren M.J., Schaap O., Breedveld G.J., Krieger E., Dekker M.C., Squitieri F., Ibanez P., Joosse M., van Dongen J.W., Vanacore N., van Swieten J.C., Brice A., Meco G., van Duijn C.M., Oostra B.A., and Heutink P. Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism. Science 299 (2003) 256-259
5. Calabresi P., Pisani A., Mercuri N.B., and Bernardi G. On the mechanisms underlying hypoxia-induced membrane depolarization in striatal neurons. Brain 118 Pt. 4 (1995) 1027-1038
6. Calabresi P., De Murtas M., Pisani A., Stefani A., Sancesario G., Mercuri N.B., and Bernardi G. Vulnerability of medium spiny striatal neurons to glutamate: role of Na+/K+ ATPase. Eur. J. Neurosci. 7 (1995) 1674-1683
7. Canet-Aviles R.M., Wilson M.A., Miller D.W., Ahmad R., McLendon C., Bandyopadhyay S., Baptista M.J., Ringe D., Petsko G.A., and Cookson M.R. The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 9103-9108
8. Dawson T.M., and Dawson V.L. Molecular pathways of neurodegeneration in Parkinson's disease. Science 302 (2003) 819-822
9. de Carvalho Aguiar P., Sweadner K.J., Penniston J.T., Zaremba J., Liu L., Caton M., Linazasoro G., Borg M., Tijssen M.A., Bressman S.B., Dobyns W.B., Brashear A., and Ozelius L.J. Mutations in the Na+/K+-ATPase alpha3 gene ATP1A3 are associated with rapid-onset dystonia parkinsonism. Neuron 43 (2004) 169-175
10. Fujiwara N., Higashi H., Shimoji K., and Yoshimura M. Effects of hypoxia on rat hippocampal neurones in vitro. J. Physiol. 384 (1987) 131-151
11. Goldberg M.S., Pisani A., Haburcak M., Vortherms T.A., Kitada T., Costa C., Tong Y., Martella G., Tscherter A., Martins A., Bernardi G., Roth B.L., Pothos E.N., Calabresi P., and Shen J. Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1. Neuron 45 (2005) 489-496
12. Guatteo E., Federici M., Siniscalchi A., Knopfel T., Mercuri N.B., and Bernardi G. Whole cell patch-clamp recordings of rat midbrain dopaminergic neurons isolate a sulphonylurea- and ATP-sensitive component of potassium currents activated by hypoxia. J. Neurophysiol. 79 (1998) 1239-1245
13. Hernandez-Sanchez C., Basile A.S., Fedorova I., Arima H., Stannard B., Fernandez A.M., Ito Y., and LeRoith D. Mice transgenically overexpressing sulfonylurea receptor 1 in forebrain resist seizure induction and excitotoxic neuron death. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 3549-3554
14. Hieber V., Siegel G.J., Fink D.J., Beaty M.W., and Mata M. Differential distribution of (Na, K)-ATPase alpha isoforms in the central nervous system. Cell. Mol. Neurobiol. 11 (1991) 253-262
15. Kim R.H., Smith P.D., Aleyasin H., Hayley S., Mount M.P., Pownall S., Wakeham A., You-Ten A.J., Kalia S.K., Horne P., Westaway D., Lozano A.M., Anisman H., Park D.S., and Mak T.W. Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 5215-5220
16. Liss B., Haeckel O., Wildmann J., Miki T., Seino S., and Roeper J. K-ATP channels promote the differential degeneration of dopaminergic midbrain neurons. Nat. Neurosci. 8 (2005) 1742-1751
17. Marinelli S., Bernardi G., Giacomini P., and Mercuri N.B. Pharmacological identification of the K(+) currents mediating the hypoglycemic hyperpolarization of rat midbrain dopaminergic neurones. Neuropharmacology 39 (2000) 1021-1028
18. Martinat C., Shendelman S., Jonason A., Leete T., Beal M.F., Yang L., Floss T., and Abeliovich A. Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons: an ES-derived cell model of primary parkinsonism. PLoS Biol. 2 (2004) e327
19. Mercuri N.B., Bonci A., Calabresi P., Stratta F., and Bernardi G. Responses of rat mesencephalic dopaminergic neurons to a prolonged period of oxygen deprivation. Neuroscience 63 (1994) 757-764
20. Mercuri N.B., Bonci A., Johnson S.W., Stratta F., Calabresi P., and Bernardi G. Effects of anoxia on rat midbrain dopamine neurons. J. Neurophysiol. 71 (1994) 1165-1173
21. Mercuri N.B., Bonci A., Calabresi P., Stefani A., and Bernardi G. Properties of the hyperpolarization-activated cation current Ih in rat midbrain dopaminergic neurons. Eur. J. Neurosci. 7 (1995) 462-469
22. Mercuri N.B., Saiardi A., Bonci A., Picetti R., Calabresi P., Bernardi G., and Borrelli E. Loss of autoreceptor function in dopaminergic neurons from dopamine D2 receptor deficient mice. Neuroscience 79 (1997) 323-327
23. Palacino J.J., Sagi D., Goldberg M.S., Krauss S., Motz C., Wacker M., Klose J., and Shen J. Mitochondrial dysfunction and oxidative damage in parkin-deficient mice. J. Biol. Chem. 279 (2004) 18614-18622
24. Panov A., Dikalov S., Shalbuyeva N., Taylor G., Sherer T., and Greenamyre J.T. Rotenone model of Parkinson disease: multiple brain mitochondria dysfunctions after short term systemic rotenone intoxication. J. Biol. Chem. 280 (2005) 42026-42035
25. Ramsay R.R., Salach J.I., Dadgar J., and Singer T.P. Inhibition of mitochondrial NADH dehydrogenase by pyridine derivatives and its possible relation to experimental and idiopathic parkinsonism. Biochem. Biophys. Res. Commun. 135 (1986) 269-275
26. Roper J., and Ashcroft F.M. Metabolic inhibition and low internal ATP activate K-ATP channels in rat dopaminergic substantia nigra neurones. Pflugers Arch. 430 (1995) 44-54
27. Schapira A.H., Cooper J.M., Dexter D., Clark J.B., Jenner P., and Marsden C.D. Mitochondrial complex I deficiency in Parkinson's disease. J. Neurochem. 54 (1990) 823-827
28. Seutin V., Shen K.Z., North R.A., and Johnson S.W. Sulfonylurea-sensitive potassium current evoked by sodium-loading in rat midbrain dopamine neurons. Neuroscience 71 (1996) 709-719
29. Shen J., and Cookson M.R. Mitochondria and dopamine: new insights into recessive parkinsonism. Neuron 43 (2004) 301-304
30. Shen K.Z., and Johnson S.W. Sodium pump evokes high density pump currents in rat midbrain dopamine neurons. J. Physiol. 512 (1998) 449-457
31. Sherer T.B., Betarbet R., Testa C.M., Seo B.B., Richardson J.R., Kim J.H., Miller G.W., Yagi T., Matsuno-Yagi A., and Greenamyre J.T. Mechanism of toxicity in rotenone models of Parkinson's disease. J. Neurosci. 23 (2003) 10756-10764
32. Taira T., Saito Y., Niki T., Iguchi-Ariga S.M., Takahashi K., and Ariga H. DJ-1 has a role in antioxidative stress to prevent cell death. EMBO Rep. 5 (2004) 213-218
33. Ved R., Saha S., Westlund B., Perier C., Burnam L., Sluder A., Hoener M., Rodrigues C.M., Alfonso A., Steer C., Liu L., Przedborski S., and Wolozin B. Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of {alpha}-synuclein, parkin, and DJ-1 in Caenorhabditis elegans. J. Biol. Chem. 280 (2005) 42655-42668
34. Yamada K., Ji J.J., Yuan H., Miki T., Sato S., Horimoto N., Shimizu T., Seino S., and Inagaki N. Protective role of ATP-sensitive potassium channels in hypoxia-induced generalized seizure. Science 292 (2001) 1543-1546
35. Yokota T., Sugawara K., Ito K., Takahashi R., Ariga H., and Mizusawa H. Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition. Biochem. Biophys. Res. Commun. 312 (2003) 1342-1348
36. Zhang L., Shimoji M., Thomas B., Moore D.J., Yu S.W., Marupudi N.I., Torp R., Torgner I.A., Ottersen O.P., Dawson T.M., and Dawson V.L. Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis. Hum. Mol. Genet. 14 (2005) 2063-2073