Intrinsic radiation resistance in human chondrosarcoma cells

Biochemical and Biophysical Research Communications

Volumn 346, Issue 2, 2006, Pages 379-385

  Moussavi Harami, Farid ^a   Mollano, Anthony ^a   Martin, James A ^a   Ayoob, Andrew ^a   Domann, Frederick E ^b   Gitelis, Steven ^c,d   Buckwalter, Joseph A ^a  

^a UNIVERSITY OF IOWA   (United States)

^b Department of Radiation Oncology ^*  (United States)

^c Section of Medical Oncology   (United States)

^d RUSH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Chondrocyte; Chondrosarcoma; DNA damage; DNA repair; p16; Radiation resistance; Tumor suppressor gene

Indexed keywords

PROTEIN P16INK4A;

APOPTOSIS; ARTICLE; CANCER CELL; CANCER RADIOTHERAPY; CHONDROSARCOMA; CLONOGENIC ASSAY; CONTROLLED STUDY; GAMMA IRRADIATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION DOSE; RADIATION RESPONSE; RADIOSENSITIVITY; STATISTICAL SIGNIFICANCE;

ACRIDINE ORANGE; APOPTOSIS; BONE NEOPLASMS; CELL LINE, TUMOR; CELL SURVIVAL; CHONDROSARCOMA; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DNA DAMAGE; GAMMA RAYS; HUMANS; RADIATION TOLERANCE; RADIATION-SENSITIZING AGENTS;

EID: 33745161814     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.05.158     Document Type: Article

References (27)

1. Terek R.M., Schwartz G.K., Devaney K., Glantz L., Mak S., Healey J.H., and Albino A.P. Chemotherapy and P-glycoprotein expression in chondrosarcoma. J. Orthop. Res. 16 (1998) 585-590
2. Gitelis S., Bertoni F., Picci P., and Companacci M. Chondrosarcoma of bone. The experience at the Institute of Ortopedico Rizzoli. Bone Joint Surg. Am. 63A (1981) 1248-11257
3. Wyman J.J., Hornstein A.M., Meitner P.A., Mak S., Verdier P., Block J.A., Pan J., and Terek R.M. Multidrug resistance-1 and P-glycoprotein in human chondrosarcoma cell lines: expression correlates with decreased intracellular doxorubicin and in vitro chemoresistance. J. Orthop. Res. 17 (1999) 935-940
4. Dunst J., Stadler P., Becker A., Lautenschlager C., Pelz T., Hansgen G., Molls M., and Kuhnt T. Tumor volume and tumor hypoxia in head and neck cancers. The amount of the hypoxic volume is important. Strahlenther. Onkol. 179 (2003) 521-526
5. Sun J., Chen Y., Li M., and Ge Z. Role of antioxidant enzymes on ionizing radiation resistance. Free Radic. Biol. Med. 24 (1998) 586-593
6. Sutherland R.M. Tumor hypoxia and gene expression-implications for malignant progression and therapy. Acta Oncol. 37 (1998) 567-574
7. Hashiguchi S., Kusuzaki K., Murata H., Takeshita H., Hashiba M., Nishimura T., Ashihara T., and Hirasawa Y. Acridine orange excited by low-dose radiation has a strong cytocidal effect on mouse osteocarcoma. Oncology 62 (2002) 85-93
8. Andreassen C.N., Alcner J., and Overgaard J. Does variability in normal tissue reactions after radiotherapy have a genetic basis-where and how to look for it?. Radiother. Oncol. 64 (2002) 131-140
9. Collis S.J., Sangar V.K., Tighe A., et al. Development of a novel rapid assay to assess the fidelity of DNA double-stranded-break repair in human tumour cells. Nucleic Acids Res. 30 (2002) E1
10. Britten R.A., Liu D., Kuny S., and Allalunic-Turner M.J. Differential level of DSB repair fidelity effected by nuclear protein extracts derived from radiosensitive and radioresistant human tumour cells. Br. J. Cancer 76 (1997) 1440-1447
11. Khanna K., and Jackson S.P. DNA double-stranded breaks: signaling, repair and the cancer connection. Nat. Genet. 27 (2001) 247-254
12. Asp J., Inerot S., Block J.A., and Lindahl A. Alterations in the regulatory pathway involving p16, pRb and cdk4 in human chondrosarcoma. J. Orthop. Res. 19 (2001) 149-154
13. Gil-Benso R., Lopez-Gines C., Lopez-Guerrero J.A., Carda C., Callaghan R.C., Navarro S., Ferrer J., Pellin A., and Llombart-Bosch A. Establishment and characterization of a continuous human chondrosarcoma cell line, ch-2870: comparative histologic and genetic studies with its tumor of origin. Lab. Invest. 83 (2003) 877-887
14. Martin J.A., Forest E., Block J.A., Klingelhutz A.J., Whited B., Gitelis S., Wilkey A., and Buckwalter J.A. Malignant transformation in human chondrosarcoma cells supported by telomerase activation and tumor suppressor inactivation. Cell Growth Differ. 13 (2002) 397-407
15. Xia F., Wang X., Wang Y.H., Tsang N.M., Yandell D.W., Kelsey K.T., and Liber H.L. Altered p53 status correlates with differences in sensitivity to radiation-induced mutation and apoptosis in two closely related human lymphoblast lines. Cancer Res. 55 (1995) 12-15
16. Sherr C.J. Principles of tumor suppression. Cell 116 (2004) 235-246
17. Asp J., Sangiorgi L., Inerot S.E., Lindahl A., Molendini L., Benassi M.S., and Picci P. Changes of the p16 gene but not the p53 gene in human chondrosarcoma tissues. Int. J. Cancer 85 (2000) 782-786
18. Jagasia A.A., Block J.A., Qureshi A., Diaz M.O., Nobori T., Gitelis S., and Iyer A.P. Chromosome 9 related aberrations and deletions of the CDKN2 and MTS2 putative tumor suppressor genes in human chondrosarcomas. Cancer Lett. 105 (1996) 91-103
19. van Beerendonk H.M., Rozeman L.B., Taminiau A.H., Sciot R., Bovee J.V., and Cleton-Jansen A.M. Molecular analysis of the INK4A/INK4A-ARF gene locus in conventional (central) chondrosarcomas and enchondromas: indication of an important gene for tumour progression. J. Pathol. 202 (2004) 359-366
20. Uhrbom L., Nister M., and Westermark B. Induction of senescence in human malignant glioma cells by p16INK4A. Oncogene 15 (1997) 505-514
21. Hall E.J. Radiobiology for the Radiologist. Fifth ed. (2000), Lippincott Williams & Wilkins, Philadelphia
22. Banáthe J.P., Kim A., and Olive P.L. Overnight lysis improves the efficiency of detection of DNA damage in the alkaline comet assay. Radiat. Res. 155 (2002) 564-571
23. Kusuzaki K., Aomori K., Suginoshita T., et al. Total tumor cell elimination with minimum damage to normal tissue in musculoskeletal sarcomas following photodynamic therapy with acridine orange. Oncology 59 (2000) 174-180
24. Takahashi T., Mizobuchi H., Toda M., Maeda A., Mizuno S., Ogawa Y., Yoshida S., and Yamamoto H. Metabolic effects of X-ray irradiation on adult human articular chondrocytes. Int. J. Mol. Med. 11 (2003) 631-634
25. Toda M., Takahashi T., Kobayashi T., Seguchi H., Ogawa Y., Yoshida S., and Yamamoto H. The role of apoptotic resistance in irradiated adult articular chondrocytes. Int. J. Mol. Med. 9 (2002) 349-352
26. Wouters B.G., and Brown J.M. Cells at intermediate oxygen levels can be more important than the hypoxic fraction in determining tumor response to fractionated radiotherapy. Radiat. Res. 147 (1997) 541-550
27. Collingridge D.R., and Rockwell S. Pentoxifylline improves the oxygenation and radiation response of BA1112 rat rhabdomyosarcomas and EMT6 mouse mammary carcinomas. Int. J. Cancer 90 (2000) 256-264