Chromosome 9 related aberrations and deletions of the CDKN2 and MTS2 putative tumor suppressor genes in human chondrosarcomas

Cancer Letters

Volumn 105, Issue 1, 1996, Pages 91-103

  Jagasia, Ashok A ^a   Block, Joel A ^b   Qureshi, Abid ^b   Diaz, Manuel O ^a   Nobori, Tsutomu ^c   Gitelis, Steven ^d   Iyer, Anand P ^d  

^a LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

^b RUSH UNIVERSITY MEDICAL CENTER   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^d NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Aberrations; Chondrosarcoma; Chromosome 9; Tumor suppressor genes

Indexed keywords

CYCLIN DEPENDENT KINASE; INTERFERON; PHOSPHORYLASE; PROTEIN KINASE INHIBITOR;

ADULT; AGED; ARTICLE; CANCER CELL CULTURE; CANCER GENETICS; CHILD; CHONDROSARCOMA; CHROMOSOME 9P; CHROMOSOME ABERRATION; CHROMOSOME ANALYSIS; FEMALE; GENE DELETION; HUMAN; HUMAN CELL; MALE; PRIORITY JOURNAL; SCHOOL CHILD; TUMOR SUPPRESSOR GENE;

EID: 0030593509     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3835(96)04274-7     Document Type: Article

References (44)

1. [1] Diaz, M.O., Rubin, C., Harden, A., Ziemin, S., Larson, R.A., Le Beau, M. and Rowley, J. (1990) Deletions of interferon genes in acute lymphoblastic leukemia. N. Engl. J. Med., 322, 77-82.
2. [2] Olopade, O.I., Jenkins, R.B., Ransom, D.T., Malik, K., Pomykala, H., Nobori, T., Cowan, J.M., Rowley, J.D. and Diaz, M.O. (1992) Molecular analysis of deletions of the short arm of chromosome 9 in human gliomas. Cancer Res., 52, 2523-2529.
3. [3] Olopade, O.I., Buchhagen, D.L., Malik, K., Sherman, K., Nobori, T., Bader, S., Nau, M.M., Gazdar, A.F., Minna, J.D. and Diaz, M.O. (1993) Homozygous loss of the interferon genes defines the critical region on 9p that is deleted in lung cancers. Cancer Res., 53, 2410-2415.
4. [4] Cannon-Albright, L.A., Goldgar, D.E., Meyer, L.J., Lewis, C.M., Anderson, D.E., Fountain, J.E., Hegi, M.E., Wiseman, R.W., Petty, E.M., Bale, A.E., Olopade, O.I., Diaz, M.O., Kwiatkowski, D.J., Piepkorn, M.W., Zone, J.J. and Skolnick, M.H. (1992) Assignment of a locus for familial melanoma, MLM, to chromosome 9p13-p22. Science, 258, 1148-1151.
5. [5] Bello, J.M. and Rey, J.A. (1990) Chromosome aberrations in metastatic ovarian cancer: relationship with abnormalities in primary tumors. Int. J. Cancer, 45, 50-54.
6. [6] Kamb, A., Gruis, N.A., Weaver-Feldhaus, J., Liu, Q., Harshman, K., Tavtigian, S.V., Stockert, E., Day, III, R.S., Johnson, B.E. and Skolnick, M.H. (1994) A cell cycle regulator potentially involved in genesis of many tumor types. Science, 264, 436-440.
7. [7] Nobori, T., Miura, K., Wu, D.J., Lois, A., Takabayashi, K. and Carson, D. (1994) Deletions of the cyclin-dependent kinase-4 inhibitor Ggne in multiple human cancers. Nature, 368, 753-756.
8. [8] Serrano, M., Hannon, G.J. and Beach, D. (1994) A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature, 366, 704-707.
9. [9] Hannon, G.J. and Beach, D. (1994) p15INK4B is a potential effector of TGF-b-induced cell cycle arrest. Nature, 371, 257-261.
10. [10] Ogawa, S., Hirano, N., Sato, N., Takahashi, T., Hangaishi, A., Tanaka, K., Kurokawa, M., Tanaka, T., Mitani, K., Yazaki, Y. and Hirai, H. (1994) Homozygous loss of the cyclin-dependent kinase 4-inhibitor (p16) gene in human leukemias. Blood, 84, 2431-2435.
11. [11] Xu, L., Sgori, D., Sterner, C.J., Beauchamp, R.L., Pinney, D.M., Keel, S., Ueki, K., Rutter, J.L., Buckler, A.J., Louis, D.N., Gusella, J.F. and Ramesh, V. (1994) Mutational analysis of CDKN2 (MTS1/p16ink4) in human breast carcinomas. Cancer Res., 54, 5262-5263.
12. [12] Caldas, C., Hahn, S.A., da Costa, L.T., Redston, M.S., Schutte, M., Seymour, A.B., Weinstein, C.L., Hruban, R.H., Yeo, C.J. and Kern, S.E. (1994) Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma. Nature Genet., 8, 27-32.
13. [13] Kamb, A., Shattuck-Eidens, D., Eeles, R., Liu, Q., Gruis, N.A., Ding, W., Hussey, C., Tran, T., Miki, Y., Weaver-Feldhaus, J., McClure, M., Aitken, J.F., Anderson, D.E., Bergman, W., Frants, R., Goldgar, D.E., Green, A., MacLennan, R., Martin, N.G., Meyer, L.J., Youl, P., Zone, J.J., Skolnick, M.H. and Cannon-Albright, L.A. (1994) Analysis of the p16 gene (CDKN2) as a candidate for the chromosome 9p melanoma susceptibility locus. Nature Genet., 8, 22-26.
14. [14] Hussusian, C.J., Struewing, J.P., Goldstein, A.M., Higgins, P.A.T., Ally, D.S., Sheahan, M.D., Clark, W.H., Tucker, M.A. and Dracopoli, N.C. (1994) Germline p16 mutations in familial melanoma. Nature Genet., 8, 15-21.
15. [15] Mori, T., Miura, K., Aoki, T., Nishihira, T., Mori, S. and Yusuke, N. (1994) Frequent somatic mutation of the MTS1/CDK4I (multiple tumor suppressor/cyclin-dependent kinase 4 inhibitor) gene in esophageal squamous cell carcinoma. Cancer Res., 54, 3396-3397.
16. [16] Wade Harper, J.J., Bigner, S.H., Bigner, D.D., Papadopoulos, N., Markowitz, S., Willson, J.K.V., Kinzler, K.W. and Vogelstein, B. (1994) Deletion of p16 and p15 genes in brain tumors. Cancer Res., 54, 6353-6358.
17. [17] Zhang, S.-Y., Klein-Szanto, A.J.P., Sauter, E.R., Shafarenko, M., Mitsunaga, S., Nobori, T., Carson, D.A., Ridge, J.A. and Goodrow, T.L. (1994) Higher frequency of alterations in the p16/CDKN2 gene in squamous cell carcinoma cell lines than in primary tumors of the head and neck. Cancer Res., 54, 5050-5053.
18. [18] Cairns, P., Mao, L., Merlo, A., Lee, D.J., Schwab, D., Eby, Y., Tokino, K., Riet, P.V.D., Blaugrund, J.E. and Sidrnasky, D. (1994) Rates of p16 (MTS1) mutations in primary tumors with 9p loss. Science, 265, 415-416.
19. [19] Hussusian, C.J., Struewing, J.P., Goldstein, A.M., Higgins, P.A.T., Ally, D.S., Sheahan, M.D., Clark, W.H., Tucker, M.A. and Dracopoli, N.C. (1994) Germline p16 mutations in familial melanoma. Nature Genet., 8, 15-21.
20. [20] Giani, C. and Finocchiaro, (1994) Mutation rate of the CDKN2 gene in malignant gliomas. Cancer Res., 54, 6338-6339.
21. [21] Block, J.A., Inerot, S.E., Gitelis, S. and Kimura, J.H. (1991) Synthesis of chondrocytic keratin sulphate-containing proteoglycans by human chondrosarcoma cells in long-term cell culture. J. Bone Joint Surg. Am., 73, 647-658.
22. [22] Vindelov, L.L., Christensen, I.J. and Nissen, N.I. (1993) A detergent trypsin method for the preparation of nucleic for flow cytometric DNA analysis. Cytometry, 3, 323-327.
23. [23] Harnden, D.G. and Klinger, H.P. (1985) An International System for Human Cytogenetic Nomenclature. Karger, Basel (published in collaboration with Cytogenet. Cell Genet.).
24. [24] Southern, E. (1975) Detection of specific sequences among DNA fragments separated by gel electrophoresis. J. Mol. Biol., 98, 503.
25. [25] Laemmli, U.K. (1990) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature, 227, 680-685.
26. [26] Platanias, L.C. and Sweet, M.E. (1994) Interferon α induces rapid tyrosine phosphorylation of the vav proto-oncogene product in hematopoietic cells. J. Biol. Chem., 269, 3143-3146.
27. [27] Bosman, F.T., Groen, F.C.A. and Ploeg, V.D.M. (1979) DNA content and chromosome number of a heteroploid human tumor cell line. Histochemistry, 60, 181-188.
28. [29] Fearon, E.R. and Vogelstein, B. (1990) A genetic model for colorectal tumorigenesis. Cell, 61, 759-767.
29. [30] Heim, S. and Mitelman, F. (1987) Cancer Cytogenetics. Alan R. Liss, New York.
30. [31] Buckwalter, J.A. (1983) The structure of human chondrosarcoma proteoglycans. J. Bone Joint Surg. Am., 65-A, 958-974.
31. [32] Claude, T.-C, Paola, D.C., Rao, U., Karakousis, C. and Sandberg, A. (1988) Recurrent breakpoints at 9q31 and 22q12.2 in extraskeletal myxoid chondrosarcoma. Cancer Genet. Cytogenet., 30, 145-150.
32. [33] Fuzesi, L., Rixen, H. and Kirschner-Hermanns, R. (1993) Cytogenetic findings in a metastasizing primary testicular chondrosarcoma. Am. J. Surg. Pathol., 17, 738-742.
33. [34] Hinrichs, S.H., Jaramillo, M.A., Gumerlock, P.H., Gardner, M.B., Lewis, J.P. and Freeman, A.E. (1985) Myxoid chondrosarcoma with a translocation involving chromosomes 9 and 22. Cancer Genet. Cytogenet., 14, 219-226.
34. [35] Hirabayashi, Y., Yoshida, M.A., Ikeuchi, T., Ishida, T., Kojima, T., Higaki, S., Machinami, R. and Tonomura, A. (1992) Chromosome rearrangements at 12q13 in two cases of chondrosarcomas. Cancer Genet. Cytogenet., 60, 35-40.
35. [36] Fletcher, J.A., Lipinski, KK., Weidner, N. and Morton, C.C. (1989) Complex cytogenetic aberrations in a well-differentiated chondrosarcoma. Cancer Genet. Cytogenet., 41, 115-121.
36. [37] Mandahl, N., Heim, S., Arheden, K., Rydholm, A., Willen, H. and Mitelman, F. (1990) Chromosomal rearrangements in chondromatous tumors. Cancer, 65, 242-248.
37. [38] Mitelman, F. (1991) Catalog of Chromosome Aberrations in Cancer, 4th edn. Wiley-Liss, New York.
38. [39] Orndal, C., Mandahl, N., Rydholm, A., Willen, H., Brosjo, O. and Mitelman, F. (1993) Chromosome aberrations and cytogenetic intratumor heterogeneity in chondrosarcomas. J. Cancer Res. Clin. Oncol. 120 51-56.
39. [40] Shen, W.-P.V., Young, R.F., Walter, B.N., Choi, B.H., Smith, M. and Katz, J. (1990) Molecular analysis of a myxoid chondrosarcoma with rearrangements of chromosomes 10 and 22. Cancer Genet. Cytogenet., 45, 207-215.
40. [41] Tarkkanen, M., Kaipainen, A., Karaharju, E., Bohling, T., Szymanska, T., Helio, H., Kivioja, A., Elomaa, I. and Knuutila, S. (1993) Cytogenetic study of 249 consecutive patients examined for a bone tumor. Cancer Genet. Cytogenet., 68, 1-21.
41. [42] Zalupski, M.M., Ensley, F.J., Ryan, J., Selvaggi, S., Baker, L.H. and Wolman, S.R. (1990) A common cytogenetic abnormality and DNA content alterations in dedifferentiated chondrosarcoma. Cancer, 66, 1176-1182.
42. [43] Solomon, E., Borrow, J. and Goddard, A.D. (1991) Chromosome aberrations and cancer. Science, 254, 1153-1160.
43. [44] Trent, J.M., Olson, S. and Lawn, R. (1982) Chromosomal localization of human leukocyte, fibroblast, and immune interferon genes by means of in situ hybridization. Proc. Natl. Acad. Sci. USA, 79, 7809-7813.
44. [45] Carrera, C.J., Eddy, R.L., Shows, T.B. and Carson, D.A. (1984) Assignment of the gene for methylthioadenosine phosphorylase to human chromosome 9 by mouse-human somatic cell hybridization. Proc. Natl. Acad. Sci. USA, 81, 2665-2668.