The role of tyrosine 177 in human 11β-hydroxysteroid dehydrogenase type 1 in substrate and inhibitor binding: an unlikely hydrogen bond donor for the substrate

Biochimica et Biophysica Acta - Proteins and Proteomics

Volumn 1764, Issue 4, 2006, Pages 824-830

  Kim, Ki Won ^a   Wang, Zhulun ^a   Busby, James ^a   Tsuruda, Trace ^a   Chen, Michelle ^a   Hale, Clarence ^a   Castro, Víctor M ^b   Svensson, Stefan ^b   Nybo, Rebecca ^a   Xiong, Fei ^a   Wang, Minghan ^a  

^a AMGEN INC   (United States)

^b BIOVITRUM AB   (Sweden)

Author keywords

11 hydroxysteroid dehydrogenase; Carbenoxolone; Cortisone; glucocorticoid receptor; GR; Site directed mutagenesis

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; CARBENOXOLONE; DEHYDROCORTICOSTERONE; GLYCYRRHETINIC ACID; TYROSINE; TYROSINE 177; UNCLASSIFIED DRUG; CORTISONE; HYDROCORTISONE;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CHO CELL; CRYSTAL STRUCTURE; ENZYME BINDING; ENZYME DEGRADATION; ENZYME INHIBITION; GENE MUTATION; GUINEA PIG; HUMAN; HYDROGEN BOND; HYDROPHILICITY; MOLECULAR MODEL; MOUSE; MUTAGENESIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; WILD TYPE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; CRICETULUS; DRUG ANTAGONISM; ENZYME SPECIFICITY; GENETICS; HAMSTER; KINETICS; METABOLISM;

CAVIA PORCELLUS; GLYCYRRHIZA; RODENTIA;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; CARBENOXOLONE; CHO CELLS; CORTISONE; CRICETINAE; CRICETULUS; GLYCYRRHETINIC ACID; HUMANS; HYDROCORTISONE; HYDROGEN BONDING; KINETICS; MODELS, MOLECULAR; SUBSTRATE SPECIFICITY; TYROSINE;

EID: 33745155430     PISSN: 15709639     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbapap.2006.02.008     Document Type: Article

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