Distinctive pattern of cytokine production and adhesion molecule expression in peripheral blood memory CD4+ T cells from patients with active Crohn's disease

Journal of Clinical Immunology

Volumn 26, Issue 3, 2006, Pages 233-242

  Tena, Jaime García De ^a,b   Manzano, Luis ^a,c   Leal, Juan Carlos ^a,b   Antonio, Esther San ^a   Sualdea, Verónica ^a   Álvarez Mon, Melchor ^a,b  

^a UNIVERSITY OF ALCALÁ   (Spain)

^b HOSPITAL UNIVERSITARIO PRÍNCIPE DE ASTURIAS   (Spain)

^c HOSPITAL RAMÓN Y CAJAL   (Spain)

Author keywords

Crohn's disease; Inflammatory bowel disease; Memory CD4+; T cell; TNF

Indexed keywords

ALPHA4 INTEGRIN; CD11 ANTIGEN; CELL ADHESION MOLECULE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 6; PADGEM PROTEIN; TUMOR NECROSIS FACTOR;

ADULT; ARTICLE; CD4+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; CROHN DISEASE; CYTOKINE PRODUCTION; DOWN REGULATION; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOPATHOGENESIS; LAMINA PROPRIA; MALE; MEMORY T LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ULCERATIVE COLITIS;

ADOLESCENT; ADULT; ANTIGENS, CD11A; ANTIGENS, CD45; CD4-POSITIVE T-LYMPHOCYTES; CELL ADHESION MOLECULES; CROHN DISEASE; CYTOKINES; FEMALE; HUMANS; INTEGRIN ALPHA4; L-SELECTIN; MALE; MIDDLE AGED; MUCOUS MEMBRANE;

EID: 33745148983     PISSN: 02719142     EISSN: 15732592     Source Type: Journal    
DOI: 10.1007/s10875-006-9016-4     Document Type: Article

References (40)

1. Fiocchi C: Inflammatory bowel disease: Etiology and pathogenesis. Gastroenterology 115:182-205, 1998
2. Elson CO: The immunology of inflammatory bowel disease. In Inflammatory Bowel Disease, Kirsner JB (ed). New York, Raven, 2000, pp 208-239
3. Podolsky DK: Inflammatory bowel disease. N Engl J Med 347:417-429, 2002
4. Papadakis KA, Targan RS: Role of cytokines in the pathogenesis of inflammatory bowel disease. Annu Rev Med 51:289-298, 2000
5. Sprent J, Surh CD: T cell memory. Annu Rev Immunol 20:551-579, 2002
6. Ley K, Kansas GS: Selectins in T-cell recruitment to non-lymphoid tissues and sites of inflammation. Nat Rev Immunol 4:325-335, 2004
7. Pribila JT, Quale AC, Mueller KL, Shimizu Y: Integrins and T cell mediated immunity. Annu Rev Immunol 22:157-180, 2004
8. Roman LI, Manzano L, De La Hera A, Abreu L, Rossi I, Alvarez-Mon M: Expanded CD4+CD45RO+ phenotype and detective proliferative response in T lymphocytes from patients with Crohn's disease. Gastroenterology 110:1008-1019, 1996
9. Mariani P, Bachetoni A, D'Alessandro M, Lomanto D, Mazzocchi P, Speranza V: Effector Th-1 cells with cytotoxic function in the intestinal lamina propria of patients with Crohn's disease. Dig Dis Sci 45:2029-2035, 2000
10. Garcia de Tena J, Manzano L, Leal JC, Antonio ES, Sualdea V, Alvarez-Mon A: Active Crohn's disease patients show a distinctive expansion of circulating memory CD4+CD45RO+CD28null T cells. J Clin Immunol 24:185-196, 2004
11. Lennard-Jones JE: Classification of inflammatory bowel disease. Scand J Gastroenterol 170(24 Suppl):2-6, 1989
12. Best WR, Becktel JM, Singleton JW, Kern F: Development of a Crohn's disease activity index. National Cooperative Crohn's Disease Study. Gastroenterology 70:439-444, 1976
13. Truelove SC, Witts LJ: Cortisone in ulcerative colitis: Final report on a therapeutic trial. BMJ 2:1041-1048, 1955
14. Garcia-Suarez J, Prieto A, Reyes E, Manzano L, Merino JL, Alvarez-Mon M: Severe chronic autoimmune thrombocytopenic purpura is associated with an expansion of CD56+ CD3- natural killer cells subset. Blood 82:1538-1545, 1993
15. Prieto A, Reyes E, Garcia-Suarez J, Carrion F, Hernandez MP, Chafer J, Alvarez-Mon M: A low blood lymphocyte count is associated with an expansion of activated cytotoxic T lymphocytes in patients with B cell chronic lymphocytic leukemia. Eur J Haematol 59:89-99, 1997
16. Prieto A, Reyes E, Diaz D, Hernandez-Fuentes MP, Monserrat J, Perucha E, Muñoz L, Vangioni R, de La Hera A, Orfao A, Alvarez-Mon M: A new method for the simultaneous analysis of growth and death of immunophenotypically defined cells in culture. Cytometry 39:56-66, 2000
17. Papadakis KA, Targan SR: Tumor necrosis factor: Biology and therapeutic inhibitors. Gastroenterology 119:1148-1157, 2000
18. Reinecker HC, Steffen M, Witthoeft T, Pflueger I, Schreiber S, MacDermott RP, Raedler A: Enhanced secretion of tumour necrosis factor-alpha, IL-6, and IL-1 beta by isolated lamina propriamononuclear cells from patients with ulcerative colitis and Crohn's disease. Clin Exp Immunol 94:174-81, 1993
19. Breese EJ, Michie CA, Nicholls SW, Murch SH, Williams CB, Domizio P, Walker-Smith JA, MacDonald TT: Tumor necrosis factor alpha-producing cells in the intestinal mucosa of children with inflammatory bowel disease. Gastroenterology 106:1455-1466, 1994
20. Braegger CP, Nicholls S, Murch SH, Stephens S, MacDonald TT: Tumour necrosis factor alpha in stool as a marker of intestinal inflammation. Lancet 339:89-91, 1992
21. Lilja I, Gustafson-Svard C, Franzen L, Sjodhal R: Tumor necrosis factor-alpha in ileal mast cells in patients with Crohn's disease. Digestion 61:68-76, 2000
22. Bouma G, Oudkerk Pool M, Scharenberg JG, Kolkman JJ, von Blomberg BM, Scheper RJ, Meuwissen SG, Pena AS: Differences in the intrinsic capacity of peripheral blood mononuclear cells to produce tumor necrosis factor alpha and beta in patients with inflammatory bowel disease and healthy controls. Scand J Gastroenterol 30:1095-1100, 1995
23. Niederau C, Backmerhoff F, Schumacher B, Niederau C: Inflammatory mediators and acute phase proteins in patients with Crohn's disease and ulcerative colitis. Hepatogastroenterology 44:90-107, 1997
24. Kucharzik T, Lugering N, Weigelt H, Adolf M, Domschke W, Stoll R: Immunoregulatory properties of IL-13 in patients with inflammatory bowel disease; Comparison with IL-4 and IL-10. Clin Exp Immunol 104:483-490, 1996
25. Cappello M, Keshav S, Prince C, Jewell DP, Gordon S: Detection of mRNAs for macrophage products in inflammatory bowel disease by in situ hybridisation. Gut 33:1214-1219, 1992
26. Ito H, Takazoe M, Fukuda Y, Hibi T, Kusugami K, Andoh A, Matsumoto T, Yamamura T, Azuma J, Nishimoto N, Yoshizaki K, Shimoyama T, Kishimoto T: A pilot randomized of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn's disease. Gastroenterology 126:989-996, 2004
27. Fais S, Capobianchi MR, Pallone F, Di Marco P, Boirivant M, Dianzani F, Torsoli A: Spontaneous release of interferon γ by intestinal lamina propria lymphocytes in Crohn's disease. Kinetics of in vitro response to interferon γ inducers. Gut 32:403-407, 1991
28. Breese E, Braegger CP, Corrigan CJ, Walker-Smith JA, MacDonald TT: Interleukin-2- and interferon-γ-secreting T cells in normal and diseased human intestinal mucosa. Immunology 78:127-131, 1993
29. Parronchi P, Romagnani P, Annunziato F, Sampognaro S, Becchio A, Giannarini L: Type 1 T-helper cell predominance and interleukin-12 expression in the gut of patients with Crohn's disease. Am J Pathol 150:823-832, 1997
30. Nakamura M, Saito H, Kasanuki J, Tamura Y, Yoshida S: Cytokine production in patients with inflammatory bowel disease. Gut 33:933-937, 1992
31. Elsasser-Beile U, von Kleist S, Gerlach S, Gallati H, Monting JS: Cytokine production in whole blood cell cultures of patients with Crohn's disease and ulcerative colitis. J Clin Lab Anal 8:447-451, 1994
32. Mutchnick MG, Lee HH, Hollander DI, Haynes GD, Chua DC: Detective in vitro gamma interferon production and elevated serum immunoreactive thymosin beta 4 levels in patients with inflammatory bowel disease. Clin Immunol Immunopathol 47:84-92, 1988
33. Cohavy O, Zhou J, Granger SW, Ware CF, Targan SR: LIGHT expression by mucosal T cells may regulate IFN-gamma expression in the intestine. J Immunol 173:251-258, 2004
34. Mocellin S, Panelli MC, Wang E, Nagorsen D, Marincola FM: The dual role of IL-10. Trends Immunol 24:36-43, 2003
35. Tilg H, van Montfrans C, van den Ende A, Kaser A, van Deventer SJ, Schreiber S, Gregor M, Ludwiczek O, Rutgeerts P, Gasche C, Koningsberger JC, Abreu L, Kuhn I, Cohard M, LeBeaut A, Grint P, Weiss G: Treatment of Crohn's disease with recombinant human interleukin 10 induces the proinflammatory cytokine interferon gamma. Gut 50:191-195, 2002
36. Garcia de Tena J, Espinosa LM, Alvarez-Mon M: N Engl J Med 347:1982-1984, 2002
37. Cominelli F: Cytokine-based therapies for Crohn's disease. N Engl J Med 351:2045-2048, 2004
38. Ghosh S, Goldin E, Gordon FH, Malchow HA, Rask-Madsen J, Rutgeerts P, Vyhnalek P, Zadorova Z, Palmer T, Donoghue S: Natalizumab for active Crohn's disease. N Engl J Med 348:24-32, 2003
39. Ellis CN, Krueger GG: Treatment of chronic plaque psoriasis by selective targeting of memory effector T lymphocytes. N Engl J Med 345:248-255, 2001
40. Kraan MC, van Kuijk AW, Dinant HJ, Goedkoop AY, Smeets TJ, de Rie MA, Dijkmans BA, Vaishnaw AK, Bos JD, Tak PP: Alefacept treatment in psoriatic arthritis: Reduction of the effector T cell population in peripheral blood and synovial tissue is associated with improvement of clinical signs of arthritis. Arthritis Rheum 46:2776-2784, 2002