WT1 influences apoptosis through transcriptional regulation of Bcl-2 family members

Cell Cycle

Volumn 5, Issue 12, 2006, Pages 1249-1253

  Loeb, David M ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Breast cancer; Kidney; Leukemia; Nephrogenesis; Oncogene; Programmed cell death; Tumor suppressor

Indexed keywords

CELL PROTEIN; ISOPROTEIN; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BFL 1; UNCLASSIFIED DRUG; WNT1 PROTEIN;

APOPTOSIS; BONE MARROW CELL; CELL LINEAGE; CELL TYPE; GENE TARGETING; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; TRANSCRIPTION REGULATION;

EID: 33745143994     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.5.12.2807     Document Type: Review

References (31)

1. Call KM, Glaser T, Ito CY, et al. Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus. Cell 1990; 60(3):509-520.
2. Gessler M, Poustka A, Cavenee W, Neve RL, Orkin SH, Bruns GAP. Homozygous deletion in Wilms' tumor of a zinc-finger gene identified by chromosome jumping. Nature 1990; 343:774-8.
3. Haber DA, Sohn RL, Buckler AJ, Pelletier J, Call KM, Housman DE. Alternative splicing and genomic structure of the Wilms tumor gene WT1. Proc Natl Acad Sci USA 1991; 88:9618-22.
4. Inoue K, Tamaki H, Ogawa H, et al. Wilms' tumor gene (WT1) competes with differentiation-inducing signal in hematopoietic progenitor cells. Blood 1998; 91:2969-76.
5. Loeb DM, Summers JL, Burwell EA, Korz D, Friedman AD, Sukumar S. An isoform of the Wilms' tumor suppressor gene potentiates granulocytic differentiation. Leukemia 2003; 17:965-71.
6. Webster NJ, Kong Y, Sharma P, Haas M, Sukumar S, Seely BL. Differential effects of Wilms tumor WT1 splice variants on the insulin receptor promoter. Biochem Mol Med 1997; 62:139-50.
7. Buckler AJ, Pelletier J, Haber DA, Glaser T, Housman DE. Isolation, characterization, and expression of the murine Wilms' tumor gene (WT1) during kidney development. Mol Cell Biol 1991; 11:1707-12.
8. Pritchard-Jones K, Fleming S, Davidson D, et al. The candidate Wilms' tumour gene is involved in genitourinary development. Nature 1990; 346:194-7.
9. Kreidberg JA, Sariola H, Loring JM, et al. WT-1 is required for early kidney development. Cell 1993; 74:679-91.
10. Englert C, Hou X, Maheswaran S, et al. WT1 suppresses synthesis of the epidermal growth factor receptor and induces apoptosis. EMBO J 1995; 14:4662-75.
11. Maheswaran S, Englert C, Bennett P, Heinrich G, Haber DA. The WT1 gene product stabilizes p53 and inhibits p53-mediated apoptosis. Genes Dev 1995; 9:2143-56.
12. Kudoh T, Ishidate T, Nakamura T, Toyoshima K, Akiyama T. Constitutive expression of the Wilms tumor suppressor gene WT1 in F9 embryonal carcinoma cells induces apoptotic cell death in response to retinoic acid. Oncogene 1996; 13:1431-9.
13. Algar EM, Khromykh T, Smith SI, Blackburn DM, Bryson GJ, Smith PJ. A WT1 antisense oligonucleotide inhibits proliferation and induces apoptosis in myeloid leukaemia cell lines. Oncogene 1996; 12:1005-14.
14. Murata Y, Kudoh T, Sugiyama H, Toyoshima K, Akiyama T. The Wilms tumor suppressor gene WT1 induces G1 arrest and apoptosis in myeloblastic leukemia M1 cells. FEBS Lett 1997; 409:41-5.
15. Menke AL, Shvarts A, Riteco N, van Ham RC, van der Eb AJ, Jochemsen AG. Wilms' tumor 1-KTS isoforms induce p53-independent apoptosis that can be partially rescued by expression of the epidermal growth factor receptor or the insulin receptor. Cancer Res 1997; 57:1353-63.
16. Cheema SK, Mishra SK, Rangnekar VM, Tari AM, Kumar R, Lopez-Berestein G. Par-4 transcriptionally regulates Bcl-2 through a WT1-binding site on the bcl-2 promoter. J Biol Chem 2003; 278:19995-20005.
17. Hewitt SM, Hamada S, McDonnell TJ, Rauscher IIIrd FJ, Saunders GF. Regulation of the proto-oncogenes bcl-2 and c-myc by the Wilms' tumor suppressor gene WT1. Cancer Res 1995; 55:5386-9.
18. Heckman C, Mochon E, Arcinas M, Boxer LM. The WT1 protein is a negative regulator of the normal bcl-2 allele in t(14;18) lymphomas. J Biol Chem 1997; 272:19609-14.
19. Mayo MW, Wang CY, Drouin SS, et al. WT1 modulates apoptosis by transcriptionally upregulating the bcl-2 proto-oncogene. EMBO J 1999; 18:3990-4003.
20. Sells SF, Wood Jr DP, Joshi-Barve SS, et al. Commonality of the gene programs induced by effectors of apoptosis in androgen-dependent and -independent prostate cells. Cell Growth Differ 1994; 5:457-66.
21. Sells SF, Han SS, Muthukkumar S, et al. Expression and function of the leucine zipper protein Par-4 in apoptosis. Mol Cell Biol 1997; 17:3823-32.
22. Adams JM, Cory S. The Bcl-2 protein family: Arbiters of cell survival. Science 1998; 281:1322-6.
23. Morrison DJ, English MA, Licht JD. WT1 induces apoptosis through transcriptional regulation of the proapoptotic Bcl-2 family member Bak. Cancer Res 2005; 65:8174-82.
24. Ito K, Oji Y, Tatsumi N, et al. Antiapoptotic function of 17AA(+)WT1 (Wilms' tumor gene) isoforms on the intrinsic apoptosis pathway. Oncogene 2006.
25. Klamt B, Koziell A, Poulat F, et al. Frasier syndrome is caused by defective alternative splicing of WT1 leading to an altered ratio of WT1 +/-KTS splice isoforms. Hum Mol Genet 1998; 7:709-14.
26. Loeb DM, Korz D, Katsnelson M, Burwell EA, Friedman AD, Sukumar S. Cyclin E is a target of WT1 transcriptional repression. J Biol Chem 2002; 277:19627-32.
27. Simpson LA, Burwell EA, Thompson KA, Shahnaz S, Chen AR, Loeb DM. The anti-apoptotic gene A1/Bfl-1 is a WT1 target gene that mediates granulocytic differentiation and resistance to chemotherapy. Blood 2006.
28. Bergmann L, Miething C, Maurer U, et al. High levels of Wilms' tumor gene (wt1) mRNA in acute myeloid leukemias are associated with a worse long-term outcome. Blood 1997; 90:1217-25.
29. Lin EY, Orlofsky A, Wang HG, Reed JC, Prystowsky MB. A1, a Bcl-2 family member, prolongs cell survival and permits myeloid differentiation. Blood 1996; 87:983-92.
30. D'Sa-Eipper C, Chinnadurai G. Functional dissection of Bfl-1, a Bcl-2 homolog: Anti-apoptosis, oncogene-cooperation and cell proliferation activities. Oncogene 1998; 16:3105-14.
31. Uhlmann EJ, D'Sa-Eipper C, Subramanian T, Wagner AJ, Hay N, Chinnadurai G. Deletion of a non-conserved region of Bcl-2 confers a novel gain of function: Suppression of apoptosis with concomitant cell proliferation. Cancer Res 1996; 56:2506-9.