A novel apoptosis cascade mediated by lysosomal lactoferrin and its participation in hepatocyte apoptosis induced by d-galactosamine

FEBS Letters

Volumn 580, Issue 15, 2006, Pages 3699-3705

  Katunuma, Nobuhiko ^a   Le, Quang Trong ^a   Murata, Etsuko ^a   Matsui, Atsushi ^a   Majima, Eiji ^b   Ishimaru, Naozumi ^c   Hayashi, Yoshio ^c   Ohashi, Atsushi ^a  

^a TOKUSHIMA BUNRI UNIVERSITY   (Japan)

^b APRO Life Science Institute   (Japan)

^c UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

Apoptosis; d Galactosamine; Lactoferrin; Lysosome; Procaspase 3; Processing

Indexed keywords

AMINOTRANSFERASE; CASPASE 3; GALACTOSE; GRANZYME B; LACTOFERRIN; PROCASPASE 3; RECOMBINANT PROTEIN; SYNTHETIC PEPTIDE; TYROSYLGLUTAMYLLYSYLTYROSYLLEUCYLGLYCYLPROLYLGLUTAMINYLTYROSYLVALYLALANYL GLYCYLISOLEUCYLTHREONYLASPARAGINYLLEUCYLLYSINE; UNCLASSIFIED DRUG;

AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CYTOPLASM; ENZYME ACTIVITY; IN VITRO STUDY; LIVER CELL; LYSOSOME; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; APOPTOSIS; CASPASE 3; CASPASES; ENZYME ACTIVATION; GALACTOSAMINE; HEPATOCYTES; LACTOFERRIN; LYSOSOMES; MICE; MOLECULAR WEIGHT; RATS;

EID: 33745116879     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2006.05.057     Document Type: Article

References (21)

1. Salvesen G.S., and Dixit V.M. Caspases, intracellular signaling by proteolysis. Cell 91 (1997) 443-446
2. Liu X., Kim C.N., Yang J., Jemmerson R., and Wang X. Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell 86 (1996) 147-157
3. Kluck R.M., Bossy-Wetzel E., Green D.R., and Newmeyer D.D. The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science 275 (1997) 1132-1136
4. Li P., Nijhawan D., Budihardjo I., Srinivasula S.M., Ahmad M., Alnemri E.S., and Wang X. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91 (1997) 479-489
5. Ishisaka R., Utsumi T., Yabuki M., Kanno T., Furuno T., Inoue M., and Utsumi K. Activation of caspase-3 like protease by digitonin-treated lysosomes. FEBS Lett. 435 (1998) 233-236
6. Ishisaka R., Utsumi T., Kanno T., Arita K., Katunuma N., Akiyama J., and Utsumi K. Participation of a cathepsin L-type protease in the activation of caspase-3. Cell Struct. Funct. 24 (1999) 465-470
7. Katunuma N., Murata E., Le Q.T., Hayashi Y., and Ohashi A. New apoptosis cascade mediated by lysosomal enzyme and its protection by epigallo-catechin gallate. Adv. Enzyme Regul. 44 (2004) 1-10
8. 1 on TNF-α status and hepatic d-galactosamine-induced apoptosis in rats. J. Gastroent. Hepatol. 13 (1998) 197-207
9. Galanos C., Freudenberg M.A., and Reutter W. Galactosamine-induced sensitization to the lethal effects of endotoxin. Proc. Natl. Acad. Sci. USA 76 (1979) 5939-5943
10. Thornberry N.A., Bull H.G., Calaycay J.R., Chapman K.T., Howard A.D., Kostura M.J., Kostura M.J., Miller D.K., Molineaux S.M., Weidner J.R., Aunins J., Elliston K.O., Ayala Jm., Casano F.J., Chin J., Ding G.J.-F., Egger L.A., Gaffney E.P., Limjuco G., Palyha O.C., Raju S.M., Ralond A.M., Salley J.P., Yamin T.T., Lee T.D., Shively J.E., MacCross M., Mumford R.A., Schumidt J.A., and Tocci M.J. A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes. Nature 356 (1992) 768-774
11. Katunuma N., Ohashi A., Sano E., Ishimaru N., Hayashi Y., and Murata E. Catechin derivatives: specific inhibitor for caspases-3, 7 and 2, and the prevention of apoptosis at the cell and animal levels. FEBS Lett. 580 (2006) 741-746
12. Fernandez-Patron C., Castellanos-Serra L., and Rodriguez P. Reverse staining of sodium dodecyl sulfate polyacrylamide gels by imidazole-zinc salts: sensitive detection of unmodified proteins. Biotechniques 12 (1992) 564-573
13. Le Q.T., Ohashi A., Hirose S., and Katunuma N. Reverse zymography using fluorogenic substrates for protease inhibitor detection. Electrophoresis 26 (2005) 1038-1045
14. Majima E., Ishida M., Miki S., Shinohara Y., and Terada H. Specific labeling of the bovine heart mitochondrial phosphate carrier with fluorescein 5-isothiocyanate: roles of Lys185 and putative adenine nucleotide recognition site in phosphate transport. J. Biol. Chem. 276 (2001) 9792-9799
15. Osada J., Aylagas H., Sanchez-Prieto J., Sanchez-Vegazo I., and Palacios-Alaiz E. Isolation of rat liver lysosomes by a single two-phase partition on dextran/polyethylene glycol. Anal. Biochem. 185 (1990) 249-253
16. Ohashi A., Murata E., Yamamoto K., Majima E., Sano E., Le Q.T., and Katunuma N. New functions of lactoferrin and β-casein in mammalian milk as cysteine protease inhibitors. BBRC 306 (2003) 98-103
17. Kihara M., Kakegawa H., Matano Y., Murata E., Tsuge H., Kido H., and Katunuma N. Chondroitin sulfate proteoglycan is a potent enhancer in the processing of procathepsin L. Biol. Chem. 383 (2002) 1925-1929
18. Sanchez L., Aranda P., Perez M.D., and Calvo M. Concentration of lactoferrin and transferrin throughout lactation in cow's colostrum and milk. Biol. Chem. Hoppe Seyler 369 (1988) 1005-1008
19. 1 protection against apoptosis induced by d-galactosamine is not related to the modulation of intracellular free radical production in primary culture of rat hepatocytes. Free Radic. Res. 36 (2002) 345-355
20. Fujita K., Matsuda E., Sekine K., Iigo M., and Tsuda H. Lactoferrin enhances Fas expression and apoptosis in the colon mucosa of azoxymethane-treated rats. Carcinogenesis 25 (2004) 1961-1966
21. Katunuma N., Le Q.T., Miyauchi R., and Hirose S. Double-layer fluorescent zymography for processing protease detection. Anal. Biochem. 347 (2005) 208-212