Formation and stability of the enolates of N-protonated proline methyl ester and proline zwitterion in aqueous solution: A nonenzymatic model for the first step in the racemization of proline catalyzed by proline racemase

Biochemistry

Volumn 42, Issue 27, 2003, Pages 8354-8361

  Williams, Glenn ^a   Maziarz III, E Peter ^a   Amyes, Tina L ^a   Wood, Troy D ^a   Richard, John P ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITES;

CATALYSIS; ENZYME KINETICS; ESTERS; HYDROLYSIS; IONIZATION; MASS SPECTROMETRY; METHANOL; PH EFFECTS; RATE CONSTANTS; SUBSTRATES;

PROTEINS;

3 QUINUCLIDINOL; AMPHOLYTE; ANION; CARBON; DEUTERIUM OXIDE; ESTER DERIVATIVE; HYDROXIDE; METHANOL; OXYGEN; POTASSIUM CHLORIDE; PROLINE METHYL ESTER; RACEMASE; SOLVENT; THIOL DERIVATIVE; UNCLASSIFIED DRUG; WATER;

ACIDITY; ALKALINITY; AQUEOUS SOLUTION; ARTICLE; DATA ANALYSIS; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME MECHANISM; ENZYME SUBSTRATE; HYDROLYSIS; MASS SPECTROMETRY; MOLECULAR MODEL; PKA; POLARIZATION; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN SYNTHESIS; PROTON TRANSPORT; RACEMIC MIXTURE; REACTION ANALYSIS; SOLVATION;

ESTERIFICATION; MODELS, CHEMICAL; PROLINE;

EID: 0037826844     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0345992     Document Type: Article

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