Crystal structure, catalytic mechanism, and mitogenic properties of Trypanosoma cruzi proline racemase

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 6, 2006, Pages 1705-1710

  Buschiazzo, Alejandro ^a   Goytia, Maira ^a   Schaeffer, Francis ^a   Degrave, Wim ^a,c   Shepard, William ^b,d   Grégoire, Christophe ^a   Chamond, Nathalie ^a   Cosson, Alain ^a   Berneman, Armand ^a   Coatnoan, Nicolas ^a   Alzari, Pedro M ^a   Minoprio, Paola ^a  

^a CNRS   (France)

^b EUROPEAN SYNCHROTRON RADIATION FACILITY   (France)

^c INSTITUTO OSWALDO CRUZ   (Brazil)

^d SYNCHROTRON SOLEIL   (France)

Author keywords

B cell mitogen; Enzyme inhibitor complex; Epimerases; Pyridoxal phosphate independent proline racemase; Titration calorimetry

Indexed keywords

2 PYRROLECARBOXYLIC ACID; AMINO ACID; CARBOXYLIC ACID; CYSTEINE; EPITOPE; MONOMER; PROLINE RACEMASE; PYRIDOXAL 5 PHOSPHATE; RACEMASE; UNCLASSIFIED DRUG;

ALPHA CHAIN; ANIMAL CELL; ARTICLE; B LYMPHOCYTE; BETA CHAIN; CATALYSIS; CELL WALL; CHIRALITY; CRYSTAL STRUCTURE; ENANTIOMER; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME INHIBITOR COMPLEX; HUMORAL IMMUNITY; LYMPHOCYTE ACTIVATION; LYMPHOCYTE PROLIFERATION; MITOGENESIS; MOUSE; NONHUMAN; POLYCLONAL ACTIVATION; PRIORITY JOURNAL; PROKARYOTE; PROTEIN FAMILY; THERMODYNAMICS; TRYPANOSOMA CRUZI;

AMINO ACID ISOMERASES; ANIMALS; BINDING SITES; CATALYSIS; CELL PROLIFERATION; CELLS, CULTURED; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; LYMPHOCYTES; MICE; MITOGENS; MODELS, MOLECULAR; PROTEIN STRUCTURE, QUATERNARY; PYRROLIDINES; THERMODYNAMICS; TRYPANOSOMA CRUZI;

ANIMALIA; BACTERIA (MICROORGANISMS); PROKARYOTA; TRYPANOSOMA CRUZI;

EID: 32444448479     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0509010103     Document Type: Article

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