Effects of cypermethrin and methyl parathion mixtures on hormone levels and immune functions in Wistar rats

Archives of Toxicology

Volumn 80, Issue 7, 2006, Pages 449-457

  Liu, Ping ^a,b   Song, Xiaoxiao ^b   Yuan, Weihong ^b   Wen, Weihua ^b   Wu, Xinan ^b   Li, Jian ^b   Chen, Xuemin ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b KUNMING MEDICAL UNIVERSITY   (China)

Author keywords

Cypermethrin; Immune function; Methyl parathion; Mixture; Reproductive hormones

Indexed keywords

CIPERMETHRIN; ESTRADIOL; FOLLITROPIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; LUTEINIZING HORMONE; PARATHION METHYL; SOLVENT; TESTOSTERONE; THYROID HORMONE;

ADRENAL GLAND; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; BODY WEIGHT; CONTROLLED STUDY; ENDOCRINE FUNCTION; EXPOSURE; FEEDING; FEMALE; FOLLITROPIN BLOOD LEVEL; IMMUNE RESPONSE; IMMUNOGLOBULIN BLOOD LEVEL; LUTEINIZING HORMONE BLOOD LEVEL; LYMPHOCYTE TRANSFORMATION; MOLECULAR INTERACTION; MOUSE; NEUTROPHIL; NONHUMAN; ORGAN WEIGHT; OVARY; PHAGOCYTOSIS; PRIORITY JOURNAL; RANDOMIZATION; RAT; TESTOSTERONE BLOOD LEVEL; THYROID HORMONE BLOOD LEVEL; WEIGHT GAIN;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; FEMALE; HORMONES; IMMUNE SYSTEM; INSECTICIDES; LETHAL DOSE 50; LYMPHOCYTE ACTIVATION; MALE; METHYL PARATHION; NEUTROPHILS; NO-OBSERVED-ADVERSE-EFFECT LEVEL; ORGAN SIZE; PHAGOCYTOSIS; PYRETHRINS; RATS; RATS, WISTAR;

ANIMALIA; RATTUS NORVEGICUS;

EID: 33745021875     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-006-0071-7     Document Type: Article

References (42)

1. Ahmed SA (2000) The immune system as a potential target for environmental estrogens (endocrine disrupters): a new emerging field. Toxicology 150:191-206
2. Bishop CA, Van Der Kraak GJ, Ng P, Smits JE, Hontela A (1998) Health of tree swallows (Tachycineta bicolor) nesting in pesticide-sprayed apple orchards in Ontario, Canada. II. Sex and thyroid hormone concentrations and testes development. J Toxicol Environ Health A 55(8):561-568
3. Bjoro T, Holmen J, Kruger O, Midthjell K, Hunstad K, Schreiner T et al (2000) Prevalence of thyroid disease, thyroid dysfunction and thyroid peroxidase in a large, unselected population. the health study of Nord-Trondelag (HUNT). Eur J Endocrinol 143:639-647
4. Blakley B, Brousseau P, Fournier M, Voccia I (1999) Immunotoxicity of pesticides: a review. Toxicol Ind Health 15(1):119-132
5. Brown V (2003) Disrupting a delicate balance: environmental effects on the thyroid. Environ Health Perspect 111(12):A642-A649
6. Carpenter DO, Arcaro KF, Bush B, Niemi WD, Pang S, Vakharia DD (1998) Human health and chemical mixtures: an overview. Environ Health Perspect 106(Suppl 6):1263-1270
7. Carpenter DO, Arcaro K, Spink DC (2002) Understanding the human health effects of chemical mixtures. Environ Health Perspect 110(Suppl 1):25-42
8. Carpy SA, Kobel W, Doe J (2000) Health risk of low-dose pesticides mixtures: a review of the 1985-1998 literature on combination toxicology and health risk assessment. J Toxicol Environ Health B 3(1):1-25
9. Crittenden PL, Carr R, Pruett SB (1998) Immunotoxicological assessment of methyl parathion in female B6C3F1 mice. J Toxicol Environ Health A 54(1):1-20
10. Feron VJ, Cassee FR, Groten JP (1998) Toxicology of chemical mixtures: international perspective. Environ Health Perspect 106(Suppl 6):1281-1289
11. Feron VJ, Cassee FR, Groten JP, van Vliet PW, van Zorge JA (2002) International issues on human health effects of exposure to chemical mixtures. Environ Health Perspect 110(Suppl 6):893-899
12. Galloway T, Handy R (2003) Immunotoxicity of organophosphorous pesticides. Ecotoxicology 12:345-363
13. Garcia SJ, Abu-Qare AW, Meeker-O'Connell WA, Borton AJ, Abou-Donia MB (2003) Methyl parathion: a review of health effects. J Toxicol Environ Health B Crit Rev 6(2):185-210
14. Garey J, Wolff MS (1998) Estrogenic and antiprogestagenic activities of pyrethroid insecticides. Biochem Biophys Res Commun 251(3):855-859
15. Garry VF, Holland SE, Erickson LL, Burroughs BL (2003) Male reproductive hormones and thyroid function in pesticide applicators in the Red River Valley of Minnesota. J Toxicol Environ Health A. 66(11):965-986
16. He F, Chen S (1999) Health impacts of pesticide exposure and approaches to prevention. Asian Pac Newsl Occup Health Saf 6:60-63
17. He F, Chen S, Tang X, Gan W, Tao B, Wen B (2002) Biological monitoring of combined exposure to organophosphates and pyrethroids. Toxicol Lett 134(1-3):119-124
18. Howdeshell KL (2002) A model of the development of the brain as a construct of the thyroid system. Environ Health Perspect 110(Suppl 3):337-348
19. Hu JY, Wang SL, Zhao RC, Yang J, Chen JH, Song L, Wang XR (2002) Effects of fenvalerate on reproductive and endocrine systems of male rats [in Chinese]. Zhong Hua Nan Ke Xue 8(1):18-21
20. Institoris L, Siroki O, Undeger U, Desi I, Nagymajtenyi L (1999) Immunotoxicological effects of repeated combined exposure by cypermethrin and the heavy metals lead and cadmium in rats. Int J Immunopharmacol 21(11):735-743
21. Jaeger JW, Carlson IH, Porter WP (1999) Endocrine, immune, and behavioral effects of aldicarb (carbamate), atrazine (triazine) and nitrate (fertilizer) mixtures at groundwater concentrations. Toxicol Ind Health 15(1-2):133-135
22. Jahnke GD, Choksi NY, Moore JA, Shelby MD (2004) Thyroid toxicants: assessing reproductive health effects. Environ Health Perspect 112:363-368
23. Landrigan PJ, Claudio L, Markowitz SB, Berkowitz GS, Brenner BL, Romero H, et al (1999) Pesticides and inner-city children: exposures, risks, and prevention. Environ Health Perspect 107(Suppl 3):431-437
24. Madsen C, Claesson MH, Ropke C (1996) Immunotoxicity of the pyrethroid insecticides deltametrin and alpha-cypermetrin. Toxicology 107(3):219-227
25. Mani U, Islam F, Prasad AK, Kumar P, Kumar VS, Maji BK, Dutta KK (2002) Steroidogenic alterations in testes and sera of rats exposed to formulated Fenvalerate by inhalation. Hum Exp Toxicol 21:593-597
26. Maiti PK, Kar A (1997) Dual role of testosterone in fenvalerate-treated mice with respect to thyroid function and lipid peroxidation. J Appl Toxicol 17(2):127-131
27. Niu Y, He F (2001) The registered pesticides in China in 1999 [in Chinese]. Chin J Ind Hyg Occup Dis 19(4):307-308
28. Ohi M, Dalsenter PR, Andrade AJM, Nascimento AJ (2004) Reproductive adverse effects of fipronil in Wistar rats. Toxicol Lett 146(2):121-127
29. Oliva A, Spira A, Multigner L (2001) Contribution of environmental factors to the risk of male infertility. Hum Reprod 16(8):1768-1776
30. Padungtod C. Lasley BL. Christiani DC. Ryan LM. Xu X (1998) Reproductive hormone profile among pesticide factory workers. J Occup Environ Med 40(12):1038-1047
31. Rhind SM (2002) Endocrine disrupting compounds and farm animals: their properties, actions and routes of exposure. Domest Anim Endocrinol 23:179-187
32. Rowat SC (1998) Integrated defense system overlaps as a disease model: with examples for multiple chemical sensitivity. Environ Health Perspect 106(Suppl 1):85-109
33. Sortur SM, Kaliwal BB (1999) Effect of methyl parathion formulation on estrous cycle and reproductive performance in albino rats. Indian J Exp Biol 37(2):176-178
34. Stiller-Winkler R, Hadnagy W, Leng G, Straube E, Idel H (1999) Immunological parameters in humans exposed to pesticides in the agricultural environment. Toxicol Lett 107(1-3):219-224
35. Straube E, Straube W, Kruger E, Bradatsch M, Jacob-Meisel M, Rose HJ (1999) Disruption of male sex hormones with regard to pesticides: pathophysiological and regulatory aspects. Toxicol Lett 107(1-3):225-231
36. Sun J, Chen B, Yao P (2000) Assessment of toxicity for combination effects of organophosphates with pyrethroids [in Chinese]. J Health Toxicol 14(3):141-144
37. Undeger U, Basaran N (2001) Effects of pesticide exposure on serum immunoglobulin and complement levels. Immunopharmacol Immunotoxicol 23(3):437-443
38. Yanez L, Ortiz D, Calderon J, Batres L, Carrizales L, Mejia J, et al (2002) Overview of human health and chemical mixtures: problems facing developing countries. Environ Health Perspect 110(Suppl 6):901-909
39. Yousef MI, El-Demerdash FM, Al-Salhen KS (2003) Protective role of isoflavones against the toxic effect of cypermethrin on semen quality and testosterone levels of rabbits. J Environ Sci Health B. 38(4):463-478
40. Zaidi SSA, Bhatnagar VK, Gandhi SJ, Shah MP, Kulkarni PK, Saiyed HN (2000) Assessment of thyroid function in pesticide formulators. Hum Exp Toxicol 19(9):497-501
41. Zoeller RT (2003) Thyroid toxicology and brain development: should we think differently? Environ Health Perspect 111(12):A628
42. Zoeller RT, Dowling ALS, Herzig CTA, Lannacone EA, Gauger KJ, Bansal R (2002) Thyroid hormone, brain development, and the environment. Environ Health Perspect 110(Suppl 3): 355-361