The NF-κB inhibitor pyrrolidine dithiocarbamate blocks IL-1β induced hyaluronan synthase 1 (HAS1) mRNA transcription, pointing at NF-κB dependence of the gene HAS1

Experimental Gerontology

Volumn 41, Issue 6, 2006, Pages 641-647

  Kao, Janet J ^a  

^a University of Hawaii at Manoa School of Nursing and Dental Hygiene   (United States)

Author keywords

Arthritis; Hyaluronan; Inflammation; PDCT; Type B synoviocytes

Indexed keywords

ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; HYALURONIC ACID; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; MESSENGER RNA; PYRROLIDINE DITHIOCARBAMATE; TUMOR NECROSIS FACTOR ALPHA; GLUCURONOSYLTRANSFERASE; HYALURONAN SYNTHASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PYRROLIDINE DERIVATIVE; PYRROLIDINE DITHIOCARBAMIC ACID; THIOCARBAMIC ACID DERIVATIVE;

ARTICLE; CELL ACTIVATION; CELL STIMULATION; CONTROLLED STUDY; GEL MOBILITY SHIFT ASSAY; GENE TRANSLOCATION; GENETIC CODE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; INFLAMMATION; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SYNOVIOCYTE; WESTERN BLOTTING; AGING; CELL CULTURE; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY; PHYSIOLOGY; SYNOVIUM;

AGING; ARTHRITIS, RHEUMATOID; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; GLUCURONOSYLTRANSFERASE; HUMANS; INTERLEUKIN-1BETA; NF-KAPPA B; PYRROLIDINES; RNA, MESSENGER; SYNOVIAL MEMBRANE; THIOCARBAMATES; TRANSCRIPTION, GENETIC;

EID: 33744996941     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exger.2006.04.003     Document Type: Article

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