Characterization of the ends and target site of a novel tetracycline resistance-encoding conjugative transposon from Enterococcus faecium 664.1H1

Journal of Bacteriology

Volumn 188, Issue 12, 2006, Pages 4356-4361

  Roberts, Adam P ^a,b   Davis, Ian J ^a   Seville, Lorna ^a   Villedieu, Aurelie ^a   Mullany, Peter ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

INTEGRASE; MERCURY; TETRACYCLINE;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL CHROMOSOME; BACTERIAL GENE; BACTERIUM CONJUGATION; DNA FLANKING REGION; EFCTN1 GENE; ENTEROCOCCUS FAECIUM; GENE INSERTION; GENE LOCATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENICITY ISLAND; PRIORITY JOURNAL; STAPHYLOCOCCUS; TET(S) GENE; TRANSPOSON;

AMINO ACID SEQUENCE; CHROMOSOMES, BACTERIAL; CONJUGATION, GENETIC; DNA TRANSPOSABLE ELEMENTS; ENTEROCOCCUS FAECIUM; GENES, BACTERIAL; INTEGRASES; MOLECULAR SEQUENCE DATA; SEQUENCE ALIGNMENT; TETRACYCLINE; TETRACYCLINE RESISTANCE;

ENTEROCOCCUS FAECALIS; ENTEROCOCCUS FAECIUM;

EID: 33744994807     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/JB.00129-06     Document Type: Article

References (26)

1. Aarestrup, F. M., Y. Agerso, P. Gerner-Smidt, M. Madsen, and L. B. Jensen. 2000. Comparison of antimicrobial resistance phenotypes and resistance genes in Enterococcus faecalis and Enterococcus faecium from humans in the community, broilers, and pigs in Denmark. Diagn. Microbiol. Infect. Dis. 37:127-137.
2. Butaye, P., L. A. Devriese, and F. Haesebrouck. 2001. Differences in antibiotic resistance patterns of Enterococcus faecalis and Enterococcus faecium strains isolated from farm and pet animals. Antimicrob. Agents Chemother. 45:1374-1378.
3. Charpentier, E., G. Gerbaud, and P. Courvalin. 1993. Characterization of a new class of tetracycline-resistance gene tet(S) in Listeria monocytogenes BM4210. Gene 131:27-34.
4. Charpentier, E., G. Gerbaud, and P. Courvalin. 1994. Presence of the Listeria tetracycline resistance gene tet(S) in Enterococcus faecalis. Antimicrob. Agents Chemother. 38:2330-2335.
5. Chung, C. T., S. L. Niemela, and R. H. Miller. 1989. One-step preparation of competent Escherichia coli: transformation and storage of bacterial cells in the same solution. Proc. Natl. Acad. Sci. USA 86:2172-2175.
6. Dahlen, G., W. Samuelsson, A. Molander, and C. Reit. 2000. Identification and antimicrobial susceptibility of enterococci isolated from the root canal. Oral Microbiol. Immunol. 15:309-312.
7. Fitzgerald, J. R., S. R. Monday, T. J. Foster, G. A. Bohach, P. J. Hartigan, W. J. Meaney, and C. J. Smyth. 2001. Characterization of a putative pathogenicity island from bovine Staphylococcus aureus encoding multiple superantigens. J. Bacteriol. 183:63-70.
8. Flannagan, S. E., L. A. Zitzow, Y. A. Su, and D. B. Clewell. 1994. Nucleotide sequence of the 18-kb conjugative transposon Tn916 from Enterococcus faecalis. Plasmid 32:350-354.
9. Giraffa, G. 2002. Enterococci from foods. FEMS Microbiol. Rev. 26:163-171.
10. Gopaul, D. N., and G. D. van Duyne. 1999. Structure and mechanism in site-specific recombination. Curr. Opin. Struct. Biol. 9:14-20.
11. Guo, F., D. N. Gopaul, and G. D. van Duyne. 1997. Structure of Cre recombinase complexed with DNA in a site-specific recombination synapse. Nature 389:40-46.
12. Hinerfeld, D., and G. Churchward. 2001. Xis protein of the conjugative transposon Tn9/6 plays dual opposing roles in transposon excision. Mol. Microbiol. 41:1459-1467.
13. Huycke, M. M., D. F. Sahm, and M. S. Gilmore. 1998. Multiple-drug resistant enterococci: the nature of the problem and an agenda for the future. Emerg. Infect. Dis. 4:239-249.
14. Jacob, A. E., and S. J. Hobbs. 1974. Conjugal transfer of plasmid-borne multiple antibiotic resistance in Streptococcus faecalis var. zymogenes. J. Bacteriol. 117:360-372.
15. Lancaster, H., A. P. Roberts, R. Bedi, M. Wilson, and P. Mullany. 2004. Characterization of Tn916S, a Tn916-like element containing the tetracycline resistance determinant tet(S). J. Bacteriol. 186:4395-4398.
16. Mundy, L. M., D. F. Sahm, and M. Gilmore. 2000. Relationships between enterococcal virulence and antimicrobial resistance. Clin. Microbiol. Rev. 13:513-522.
17. Ng, L. K., I. Martin, M. Alfa, and M. Mulvey. 2001. Multiplex PCR for the detection of tetracycline resistant genes. Mol. Cell. Probes 15:209-215.
18. Nunes-Düby, S. E., H. J. Kwon, R. S. Tirumalai, T. Ellenberger, and A. Landy. 1998. Similarities and differences among 105 members of the Int family of site-specific recombinases. Nucleic Acids Res. 26:391-406.
19. Perreten, V., F. Schwarz, L. Cresta, M. Boeglin, G. Dasen, and M. Teuber. 1997. Antibiotic resistance spread in food. Nature 389:801-802.
20. Rice, L. B. 1998. Tn916 family conjugative transposons and dissemination of antimicrobial resistance determinants. Antimicrob. Agents Chemother. 42: 1871-1877.
21. Roberts, A. P., P. Mullany, and M. Wilson. 2001. Gene transfer in bacterial biofilms. Methods Enzymol. 336:60-65.
22. Rudy, C., K. L. Taylor, D. Hinerfeld, J. R. Scott, and G. Churchward. 1997. Excision of a conjugative transposon in vitro by the Int and Xis proteins of Tn916. Nucleic Acids Res. 25:4061-4066.
23. Shepard, B. D., and M. S. Gilmore. 2002. Antibiotic-resistant enterococci: the mechanisms and dynamics of drug introduction and resistance. Microbes Infect. 4:215-224.
24. Summers, A. O., J. Wireman, M. J. Vimy, F. L. Lorscheider, B. Marshall, S. B. Levy, S. Bennett, and L. Billard. 1993. Mercury released from dental "silver" fillings provokes an increase in mercury- and antibiotic-resistant bacteria in oral and intestinal floras of primates. Antimicrob. Agents Chemother. 37:825-834.
25. Ubeda, C., M. A. Tormo, C. Cucarella, P. Trotonda, T. J. Foster, I. Lasa, and J. R. Penades. 2003. Sip, an integrase protein with excision, circularization and integration activities, defines a new family of mobile Staphylococcus aureus pathogenicity islands. Mol. Microbiol. 49:193-210.
26. Wu, Z., R. I. Gumport, and J. F. Gardner. 1998. Defining the structural and functional roles of the carboxyl region of the bacteriophage lambda excisionase (Xis) protein. J. Mol. Biol. 281:651-661.