-
1
-
-
0034604110
-
Role of transforming growth factor beta in human disease
-
Blobe G.C., Schiemann W.P., and Lodish H.F. Role of transforming growth factor beta in human disease. N. Engl. J. Med. 342 (2000) 1350-1358
-
(2000)
N. Engl. J. Med.
, vol.342
, pp. 1350-1358
-
-
Blobe, G.C.1
Schiemann, W.P.2
Lodish, H.F.3
-
2
-
-
0034785348
-
TGF-β signaling in tumor suppression and cancer progression
-
Derynck R., Akhurst R.J., and Balmain A. TGF-β signaling in tumor suppression and cancer progression. Nat. Genet. 29 (2001) 117-129
-
(2001)
Nat. Genet.
, vol.29
, pp. 117-129
-
-
Derynck, R.1
Akhurst, R.J.2
Balmain, A.3
-
3
-
-
0024791389
-
Potentiation of invasive capacity of rat ascites hepatoma cells by transforming growth factor-β
-
Mukai M., Shinkai K., Komatsu K., and Akedo H. Potentiation of invasive capacity of rat ascites hepatoma cells by transforming growth factor-β. Jpn. J. Cancer Res. 80 (1989) 107-110
-
(1989)
Jpn. J. Cancer Res.
, vol.80
, pp. 107-110
-
-
Mukai, M.1
Shinkai, K.2
Komatsu, K.3
Akedo, H.4
-
4
-
-
0032473479
-
Transforming growth factor-beta1 enhances the invasiveness of human MDA-MB-231 breast cancer cells by up-regulating urokinase activity
-
Farina A.R., Coppa A., Tiberio A., Tacconelli A., Turco A., Colletta G., Gulino A., and Mackay A.R. Transforming growth factor-beta1 enhances the invasiveness of human MDA-MB-231 breast cancer cells by up-regulating urokinase activity. Int. J. Cancer 75 (1998) 721-730
-
(1998)
Int. J. Cancer
, vol.75
, pp. 721-730
-
-
Farina, A.R.1
Coppa, A.2
Tiberio, A.3
Tacconelli, A.4
Turco, A.5
Colletta, G.6
Gulino, A.7
Mackay, A.R.8
-
5
-
-
0034673243
-
Transforming growth factors β(1) (TGF-β(1)) and TGF-β(2) promote glioma cell migration via Up-regulation of α(V)β(3) integrin expression
-
Platten M., Wick W., Wild-Bode C., Aulwurm S., Dichgans J., and Weller M. Transforming growth factors β(1) (TGF-β(1)) and TGF-β(2) promote glioma cell migration via Up-regulation of α(V)β(3) integrin expression. Biochem. Biophys. Res. Commun. 268 (2000) 607-611
-
(2000)
Biochem. Biophys. Res. Commun.
, vol.268
, pp. 607-611
-
-
Platten, M.1
Wick, W.2
Wild-Bode, C.3
Aulwurm, S.4
Dichgans, J.5
Weller, M.6
-
6
-
-
0036317838
-
Transforming growth factor-β1 triggers hepatocellular carcinoma invasiveness via α3β1 integrin
-
Giannelli G., Fransvea E., Marinosci F., Bergamini C., Colucci S., Schiraldi O., and Antonaci S. Transforming growth factor-β1 triggers hepatocellular carcinoma invasiveness via α3β1 integrin. Am. J. Pathol. 161 (2002) 183-193
-
(2002)
Am. J. Pathol.
, vol.161
, pp. 183-193
-
-
Giannelli, G.1
Fransvea, E.2
Marinosci, F.3
Bergamini, C.4
Colucci, S.5
Schiraldi, O.6
Antonaci, S.7
-
7
-
-
1942442183
-
Stromal cell-derived factor-1α promotes melanoma cell invasion across basement membranes involving stimulation of membrane-type 1 matrix metalloproteinase and Rho GTPase activities
-
Bartolome R.A., Galvez B.G., Longo N., Baleux F., Van Muijen G.N., Sanchez-Mateos P., Arroyo A.G., and Teixido J. Stromal cell-derived factor-1α promotes melanoma cell invasion across basement membranes involving stimulation of membrane-type 1 matrix metalloproteinase and Rho GTPase activities. Cancer Res. 64 (2004) 2534-2543
-
(2004)
Cancer Res.
, vol.64
, pp. 2534-2543
-
-
Bartolome, R.A.1
Galvez, B.G.2
Longo, N.3
Baleux, F.4
Van Muijen, G.N.5
Sanchez-Mateos, P.6
Arroyo, A.G.7
Teixido, J.8
-
8
-
-
0023037890
-
The antiproliferative effect of type beta transforming growth factor occurs at a level distal from receptors for growth-activating factors
-
Like B., and Massague J. The antiproliferative effect of type beta transforming growth factor occurs at a level distal from receptors for growth-activating factors. J. Biol. Chem. 261 (1986) 13426-13429
-
(1986)
J. Biol. Chem.
, vol.261
, pp. 13426-13429
-
-
Like, B.1
Massague, J.2
-
9
-
-
0033492845
-
Reorganization of myosin and focal adhesion proteins in Swiss 3T3 fibroblasts induced by transforming growth factor β
-
Lee K.M., Park J., Kim J.H., Yie S.W., Chun G.T., Kim P.H., and Choi E.Y. Reorganization of myosin and focal adhesion proteins in Swiss 3T3 fibroblasts induced by transforming growth factor β. Cell Biol. Int. 23 (1999) 507-517
-
(1999)
Cell Biol. Int.
, vol.23
, pp. 507-517
-
-
Lee, K.M.1
Park, J.2
Kim, J.H.3
Yie, S.W.4
Chun, G.T.5
Kim, P.H.6
Choi, E.Y.7
-
10
-
-
0023900160
-
Alteration in growth, cell morphology, and cytoskeletal structures of KB cells induced by epidermal growth factor and transforming growth factor-β
-
Koyasu S., Kadowaki T., Nishida E., Tobe K., Abe E., Kasuga M., Sakai H., and Yahara I. Alteration in growth, cell morphology, and cytoskeletal structures of KB cells induced by epidermal growth factor and transforming growth factor-β. Exp. Cell Res. 176 (1988) 107-116
-
(1988)
Exp. Cell Res.
, vol.176
, pp. 107-116
-
-
Koyasu, S.1
Kadowaki, T.2
Nishida, E.3
Tobe, K.4
Abe, E.5
Kasuga, M.6
Sakai, H.7
Yahara, I.8
-
11
-
-
0032715516
-
Antisense oligodeoxynucleotide complementary to smooth muscle alpha-actin inhibits endothelial-mesenchymal transformation during chick cardiogenesis
-
Nakajima Y., Yamagishi T., Yoshimura K., Nomura M., and Nakamura H. Antisense oligodeoxynucleotide complementary to smooth muscle alpha-actin inhibits endothelial-mesenchymal transformation during chick cardiogenesis. Dev. Dyn. 216 (1999) 489-498
-
(1999)
Dev. Dyn.
, vol.216
, pp. 489-498
-
-
Nakajima, Y.1
Yamagishi, T.2
Yoshimura, K.3
Nomura, M.4
Nakamura, H.5
-
12
-
-
0025639152
-
Effects of transforming growth factor type beta on expression of cytoskeletal proteins in endosteal mouse osteoblastic cells
-
Lomri A., and Marie P.J. Effects of transforming growth factor type beta on expression of cytoskeletal proteins in endosteal mouse osteoblastic cells. Bone 11 (1990) 445-451
-
(1990)
Bone
, vol.11
, pp. 445-451
-
-
Lomri, A.1
Marie, P.J.2
-
13
-
-
0032559362
-
Rho GTPases and the actin cytoskeleton
-
Hall A. Rho GTPases and the actin cytoskeleton. Science 279 (1998) 509-514
-
(1998)
Science
, vol.279
, pp. 509-514
-
-
Hall, A.1
-
14
-
-
0032589269
-
Effectors for the Rho GTPases
-
Aspenstrom P. Effectors for the Rho GTPases. Curr. Opin. Cell Biol. 11 (1999) 95-102
-
(1999)
Curr. Opin. Cell Biol.
, vol.11
, pp. 95-102
-
-
Aspenstrom, P.1
-
15
-
-
0032939619
-
Rho GTPases are over-expressed in human tumors
-
Fritz G., Just I., and Kaina B. Rho GTPases are over-expressed in human tumors. Int. J. Cancer 81 (1999) 682-687
-
(1999)
Int. J. Cancer
, vol.81
, pp. 682-687
-
-
Fritz, G.1
Just, I.2
Kaina, B.3
-
16
-
-
0031577698
-
Rho proteins induce metastatic properties in vivo
-
del Peso L., Hernandez-Alcoceba R., Embade N., Carnero A., Esteve P., Paje C., and Lacal J.C. Rho proteins induce metastatic properties in vivo. Oncogene 15 (1997) 3047-3057
-
(1997)
Oncogene
, vol.15
, pp. 3047-3057
-
-
del Peso, L.1
Hernandez-Alcoceba, R.2
Embade, N.3
Carnero, A.4
Esteve, P.5
Paje, C.6
Lacal, J.C.7
-
17
-
-
0032527809
-
Invasion of T-lymphoma cells: cooperation between Rho family GTPases and lysophospholipid receptor signaling
-
Stam J.C., Michiels F., van der Kammen R.A., Moolenaar W.H., and Collard J.G. Invasion of T-lymphoma cells: cooperation between Rho family GTPases and lysophospholipid receptor signaling. Embo J. 17 (1998) 4066-4074
-
(1998)
Embo J.
, vol.17
, pp. 4066-4074
-
-
Stam, J.C.1
Michiels, F.2
van der Kammen, R.A.3
Moolenaar, W.H.4
Collard, J.G.5
-
18
-
-
0033561508
-
Overexpression of small GTP-binding protein RhoA promotes invasion of tumor cells
-
Yoshioka K., Nakamori S., and Itoh K. Overexpression of small GTP-binding protein RhoA promotes invasion of tumor cells. Cancer Res. 59 (1999) 2004-2010
-
(1999)
Cancer Res.
, vol.59
, pp. 2004-2010
-
-
Yoshioka, K.1
Nakamori, S.2
Itoh, K.3
-
19
-
-
0029879826
-
Rho-mediated protein tyrosine phosphorylation in lysophosphatidic-acid-induced tumor-cell invasion
-
Imamura F., Shinkai K., Mukai M., Yoshioka K., Komagome R., Iwasaki T., and Akedo H. Rho-mediated protein tyrosine phosphorylation in lysophosphatidic-acid-induced tumor-cell invasion. Int. J. Cancer 65 (1996) 627-632
-
(1996)
Int. J. Cancer
, vol.65
, pp. 627-632
-
-
Imamura, F.1
Shinkai, K.2
Mukai, M.3
Yoshioka, K.4
Komagome, R.5
Iwasaki, T.6
Akedo, H.7
-
20
-
-
0034602561
-
Hepatoma cell migration through a mesothelial cell monolayer is inhibited by cyclic AMP-elevating agents via a Rho-dependent pathway
-
Mukai M., Nakamura H., Tatsuta M., Iwasaki T., Togawa A., Imamura F., and Akedo H. Hepatoma cell migration through a mesothelial cell monolayer is inhibited by cyclic AMP-elevating agents via a Rho-dependent pathway. FEBS Lett. 484 (2000) 69-73
-
(2000)
FEBS Lett.
, vol.484
, pp. 69-73
-
-
Mukai, M.1
Nakamura, H.2
Tatsuta, M.3
Iwasaki, T.4
Togawa, A.5
Imamura, F.6
Akedo, H.7
-
21
-
-
0031974721
-
Overexpression of the RhoC gene correlates with progression of ductal adenocarcinoma of the pancreas
-
Suwa H., Ohshio G., Imamura T., Watanabe G., Arii S., Imamura M., Narumiya S., Hiai H., and Fukumoto M. Overexpression of the RhoC gene correlates with progression of ductal adenocarcinoma of the pancreas. Br. J. Cancer 77 (1998) 147-152
-
(1998)
Br. J. Cancer
, vol.77
, pp. 147-152
-
-
Suwa, H.1
Ohshio, G.2
Imamura, T.3
Watanabe, G.4
Arii, S.5
Imamura, M.6
Narumiya, S.7
Hiai, H.8
Fukumoto, M.9
-
22
-
-
0034667370
-
RhoC GTPase, a novel transforming oncogene for human mammary epithelial cells that partially recapitulates the inflammatory breast cancer phenotype
-
van Golen K.L., Wu Z.F., Qiao X.T., Bao L.W., and Merajver S.D. RhoC GTPase, a novel transforming oncogene for human mammary epithelial cells that partially recapitulates the inflammatory breast cancer phenotype. Cancer Res. 60 (2000) 5832-5838
-
(2000)
Cancer Res.
, vol.60
, pp. 5832-5838
-
-
van Golen, K.L.1
Wu, Z.F.2
Qiao, X.T.3
Bao, L.W.4
Merajver, S.D.5
-
23
-
-
0242694457
-
Higher expression of RhoC is related to invasiveness in non-small cell lung carcinoma
-
Shikada Y., Yoshino I., Okamoto T., Fukuyama S., Kameyama T., and Maehara Y. Higher expression of RhoC is related to invasiveness in non-small cell lung carcinoma. Clin. Cancer Res. 9 (2003) 5282-5286
-
(2003)
Clin. Cancer Res.
, vol.9
, pp. 5282-5286
-
-
Shikada, Y.1
Yoshino, I.2
Okamoto, T.3
Fukuyama, S.4
Kameyama, T.5
Maehara, Y.6
-
24
-
-
0038679226
-
Up-regulation of small GTPases, RhoA and RhoC, is associated with tumor progression in ovarian carcinoma
-
Horiuchi A., Imai T., Wang C., Ohira S., Feng Y., Nikaido T., and Konishi I. Up-regulation of small GTPases, RhoA and RhoC, is associated with tumor progression in ovarian carcinoma. Lab. Invest. 83 (2003) 861-870
-
(2003)
Lab. Invest.
, vol.83
, pp. 861-870
-
-
Horiuchi, A.1
Imai, T.2
Wang, C.3
Ohira, S.4
Feng, Y.5
Nikaido, T.6
Konishi, I.7
-
25
-
-
0034601487
-
Genomic analysis of metastasis reveals an essential role for RhoC
-
Clark E.A., Golub T.R., Lander E.S., and Hynes R.O. Genomic analysis of metastasis reveals an essential role for RhoC. Nature 406 (2000) 532-535
-
(2000)
Nature
, vol.406
, pp. 532-535
-
-
Clark, E.A.1
Golub, T.R.2
Lander, E.S.3
Hynes, R.O.4
-
26
-
-
24344486013
-
RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis
-
Hakem A., Sanchez-Sweatman O., You-Ten A., Duncan G., Wakeham A., Khokha R., and Mak T.W. RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis. Genes Dev. 19 (2005) 1974-1979
-
(2005)
Genes Dev.
, vol.19
, pp. 1974-1979
-
-
Hakem, A.1
Sanchez-Sweatman, O.2
You-Ten, A.3
Duncan, G.4
Wakeham, A.5
Khokha, R.6
Mak, T.W.7
-
27
-
-
0035185853
-
Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism
-
Bhowmick N.A., Ghiassi M., Bakin A., Aakre M., Lundquist C.A., Engel M.E., Arteaga C.L., and Moses H.L. Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism. Mol. Biol. Cell 12 (2001) 27-36
-
(2001)
Mol. Biol. Cell
, vol.12
, pp. 27-36
-
-
Bhowmick, N.A.1
Ghiassi, M.2
Bakin, A.3
Aakre, M.4
Lundquist, C.A.5
Engel, M.E.6
Arteaga, C.L.7
Moses, H.L.8
-
28
-
-
0036197606
-
Transforming growth factor-β-induced mobilization of actin cytoskeleton requires signaling by small GTPases Cdc42 and RhoA
-
Edlund S., Landstrom M., Heldin C.H., and Aspenstrom P. Transforming growth factor-β-induced mobilization of actin cytoskeleton requires signaling by small GTPases Cdc42 and RhoA. Mol. Biol. Cell 13 (2002) 902-914
-
(2002)
Mol. Biol. Cell
, vol.13
, pp. 902-914
-
-
Edlund, S.1
Landstrom, M.2
Heldin, C.H.3
Aspenstrom, P.4
-
29
-
-
0036168355
-
Characterization of RhoC expression in benign and malignant breast disease: a potential new marker for small breast carcinomas with metastatic ability
-
Kleer C.G., van Golen K.L., Zhang Y., Wu Z.F., Rubin M.A., and Merajver S.D. Characterization of RhoC expression in benign and malignant breast disease: a potential new marker for small breast carcinomas with metastatic ability. Am. J. Pathol. 160 (2002) 579-584
-
(2002)
Am. J. Pathol.
, vol.160
, pp. 579-584
-
-
Kleer, C.G.1
van Golen, K.L.2
Zhang, Y.3
Wu, Z.F.4
Rubin, M.A.5
Merajver, S.D.6
-
30
-
-
0022570607
-
Interaction of rat ascites hepatoma cells with cultured mesothelial cell layers: a model for tumor invasion
-
Akedo H., Shinkai K., Mukai M., Mori Y., Tateishi R., Tanaka K., Yamamoto R., and Morishita T. Interaction of rat ascites hepatoma cells with cultured mesothelial cell layers: a model for tumor invasion. Cancer Res. 46 (1986) 2416-2422
-
(1986)
Cancer Res.
, vol.46
, pp. 2416-2422
-
-
Akedo, H.1
Shinkai, K.2
Mukai, M.3
Mori, Y.4
Tateishi, R.5
Tanaka, K.6
Yamamoto, R.7
Morishita, T.8
-
31
-
-
0037405501
-
Central role for Rho in TGF-β1-induced α-smooth muscle actin expression during epithelial-mesenchymal transition
-
Masszi A., Di Ciano C., Sirokmany G., Arthur W.T., Rotstein O.D., Wang J., McCulloch C.A., Rosivall L., Mucsi I., and Kapus A. Central role for Rho in TGF-β1-induced α-smooth muscle actin expression during epithelial-mesenchymal transition. Am. J. Physiol. Renal Physiol. 284 (2003) F911-F924
-
(2003)
Am. J. Physiol. Renal Physiol.
, vol.284
-
-
Masszi, A.1
Di Ciano, C.2
Sirokmany, G.3
Arthur, W.T.4
Rotstein, O.D.5
Wang, J.6
McCulloch, C.A.7
Rosivall, L.8
Mucsi, I.9
Kapus, A.10
-
32
-
-
15744394838
-
LIM-kinase 2 and cofilin phosphorylation mediate actin cytoskeleton reorganization induced by transforming growth factor-β
-
Vardouli L., Moustakas A., and Stournaras C. LIM-kinase 2 and cofilin phosphorylation mediate actin cytoskeleton reorganization induced by transforming growth factor-β. J. Biol. Chem. 280 (2005) 11448-11457
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 11448-11457
-
-
Vardouli, L.1
Moustakas, A.2
Stournaras, C.3
-
33
-
-
0036305635
-
ROCK and Dia have opposing effects on adherens junctions downstream of Rho
-
Sahai E., and Marshall C.J. ROCK and Dia have opposing effects on adherens junctions downstream of Rho. Nat. Cell Biol. 4 (2002) 408-415
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 408-415
-
-
Sahai, E.1
Marshall, C.J.2
-
34
-
-
9244237677
-
Functional analysis of the contribution of RhoA and RhoC GTPases to invasive breast carcinoma
-
Simpson K.J., Dugan A.S., and Mercurio A.M. Functional analysis of the contribution of RhoA and RhoC GTPases to invasive breast carcinoma. Cancer Res. 64 (2004) 8694-8701
-
(2004)
Cancer Res.
, vol.64
, pp. 8694-8701
-
-
Simpson, K.J.1
Dugan, A.S.2
Mercurio, A.M.3
-
35
-
-
0242666266
-
A novel strategy for specifically down-regulating individual Rho GTPase activity in tumor cells
-
Wang L., Yang L., Luo Y., and Zheng Y. A novel strategy for specifically down-regulating individual Rho GTPase activity in tumor cells. J. Biol. Chem. 278 (2003) 44617-44625
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 44617-44625
-
-
Wang, L.1
Yang, L.2
Luo, Y.3
Zheng, Y.4
-
36
-
-
19944432271
-
Anti-RhoA and anti-RhoC siRNAs Inhibit the proliferation and invasiveness of MDA-MB-231 breast cancer cells in vitro and in vivo
-
Pille J.Y., Denoyelle C., Varet J., Bertrand J.R., Soria J., Opolon P., Lu H., Pritchard L.L., Vannier J.P., Malvy C., Soria C., and Li H. Anti-RhoA and anti-RhoC siRNAs Inhibit the proliferation and invasiveness of MDA-MB-231 breast cancer cells in vitro and in vivo. Mol. Ther. 11 (2005) 267-274
-
(2005)
Mol. Ther.
, vol.11
, pp. 267-274
-
-
Pille, J.Y.1
Denoyelle, C.2
Varet, J.3
Bertrand, J.R.4
Soria, J.5
Opolon, P.6
Lu, H.7
Pritchard, L.L.8
Vannier, J.P.9
Malvy, C.10
Soria, C.11
Li, H.12
-
37
-
-
0036086409
-
Blockade of TGF-β inhibits mammary tumor cell viability, migration, and metastases
-
Muraoka R.S., Dumont N., Ritter C.A., Dugger T.C., Brantley D.M., Chen J., Easterly E., Roebuck L.R., Ryan S., Gotwals P.J., Koteliansky V., and Arteaga C.L. Blockade of TGF-β inhibits mammary tumor cell viability, migration, and metastases. J. Clin. Invest. 109 (2002) 1551-1559
-
(2002)
J. Clin. Invest.
, vol.109
, pp. 1551-1559
-
-
Muraoka, R.S.1
Dumont, N.2
Ritter, C.A.3
Dugger, T.C.4
Brantley, D.M.5
Chen, J.6
Easterly, E.7
Roebuck, L.R.8
Ryan, S.9
Gotwals, P.J.10
Koteliansky, V.11
Arteaga, C.L.12
-
38
-
-
0035893740
-
Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models
-
Lobell R.B., Omer C.A., Abrams M.T., Bhimnathwala H.G., Brucker M.J., Buser C.A., Davide J.P., deSolms S.J., Dinsmore C.J., Ellis-Hutchings M.S., Kral A.M., Liu D., Lumma W.C., Machotka S.V., Rands E., Williams T.M., Graham S.L., Hartman G.D., Oliff A.I., Heimbrook D.C., and Kohl N.E. Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models. Cancer Res. 61 (2001) 8758-8768
-
(2001)
Cancer Res.
, vol.61
, pp. 8758-8768
-
-
Lobell, R.B.1
Omer, C.A.2
Abrams, M.T.3
Bhimnathwala, H.G.4
Brucker, M.J.5
Buser, C.A.6
Davide, J.P.7
deSolms, S.J.8
Dinsmore, C.J.9
Ellis-Hutchings, M.S.10
Kral, A.M.11
Liu, D.12
Lumma, W.C.13
Machotka, S.V.14
Rands, E.15
Williams, T.M.16
Graham, S.L.17
Hartman, G.D.18
Oliff, A.I.19
Heimbrook, D.C.20
Kohl, N.E.21
more..
-
39
-
-
0036158675
-
3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors reduce human pancreatic cancer cell invasion and metastasis
-
Kusama T., Mukai M., Iwasaki T., Tatsuta M., Matsumoto Y., Akedo H., Inoue M., and Nakamura H. 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors reduce human pancreatic cancer cell invasion and metastasis. Gastroenterology 122 (2002) 308-317
-
(2002)
Gastroenterology
, vol.122
, pp. 308-317
-
-
Kusama, T.1
Mukai, M.2
Iwasaki, T.3
Tatsuta, M.4
Matsumoto, Y.5
Akedo, H.6
Inoue, M.7
Nakamura, H.8
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